TF Author Results

First 250 Results - TF Author - Next 210 Results
TF Author - AHR to NR1I2 - TF Author - NR1I3 to ZHX1

Gene ID Last Name Gene2PubmedReferences (2003 or more recent) Gene2Pubmed Links
TP53 (7157) Fersht 11 The central region of HDM2 provides a second binding site for p53.(Centre for Protein Engineering, Medical Research Council, Hills Road, Cambridge CB2 2QH, United Kingdom.) 16432196,Core domain interactions in full-length p53 in solution.(Medical Research Council Centre for Protein Engineering, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom.) 16461914,Solution structure of p53 core domain: structural basis for its instability.(Medical Research Council Centre for Protein Engineering, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom.) 16461916
TP53 (7157) Chen 9 GPX2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent manner.(Department of Cell Biology, The University of Alabama at Birmingham, Birmingham, Alabama 35294-0005, USA.) 16446369,DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation.(Department of Cell Biology, The University of Alabama at Birmingham, AL 35294-0005, USA.) 16449651,Myosin VI is a mediator of the p53-dependent cell survival pathway.(Department of Cell Biology, MCLM 660, 1530 3rd Ave. S, Birmingham, AL 35294-0005, USA.) 16507995
TP53 (7157) Wu 8 Analysis of p53 and vascular endothelial growth factor expression in human gallbladder carcinoma for the determination of tumor vascularity.(Department of General Surgery, Second Affiliated Hospital, China Medical University, Shenyang 110004, China. nc.moc.oohay|yt_noegrus#nc.moc.oohay|yt_noegrus) 16489641,Anti-angiogenesis mediated by angiostatin K1-3, K1-4 and K1-4.5. Involvement of p53, FasL, AKT and mRNA deregulation.(Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan, Republic of China.) 16601838,NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.(Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095, USA.) 16697957
TP53 (7157) Liu 7 Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities.(The Hormel Institute, University of Minnesota, Austin, 55912, USA. moc.liamtoh|8861ilwd#moc.liamtoh|8861ilwd) 16501611,Mechanistic insights into maintenance of high p53 acetylation by PTEN.(Department of Biochemistry, University of California, Riverside, Riverside, California 92521, USA.) 16916644,Unique substitution of CHEK2 and TP53 mutations implicated in primary prostate tumors and cancer cell lines.(Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic/Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.) 16941491
TP53 (7157) Li 7 Apoptotic DNA fragmentation factor maintains chromosome stability in a P53-independent manner.(Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.) 16619042,Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation.(Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Life Sciences College, Nanjing Normal University, Nanjing 210097, China.) 16753148,Correlation of p53 gene mutation and expression of P53 protein in cholangiocarcinoma.(Department of Hepatobiliary Surgery of Yantai Yuhuangding Hospital, Yantai 264000, Shangdong Province, China. ten.362|436uil#ten.362|436uil) 16937443
TP53 (7157) Wang 6 Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway.(Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan.) 15791651,APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance.(Department of Surgery, Kaohsiung Medical University, Kaohsiung, Taiwan.) 15943410,NMR solution structure of a peptide from the mdm-2 binding domain of the p53 protein that is selectively cytotoxic to cancer cells.(Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, 60 Haven Avenue, New York, New York 10032, USA.) 14967026
TP53 (7157) Lu 6 Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism.(Department of Biochemistry and Molecular Biology, School of Medicine, Oregon Health and Science University, Portland, Oregon 97239.) 16803902,Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315.(Ludwig Institute for Cancer Research, University College London Branch, London, UK.) 16037820,Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation.(Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK.) 15782125
TP53 (7157) Harris 5 Tumor suppressor p53 represses transcription of RECQ4 helicase.(Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.) 15674334,Prognostic implications of molecular and immunohistochemical profiles of the Rb and p53 cell cycle regulatory pathways in primary non-small cell lung carcinoma.(Department of Pathology, Cork University Hospital, Cork, Ireland.) 15671551,p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis.(Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892-4255, USA.) 15059885
TP53 (7157) Zhang 4 The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation.(Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People's Republic of China.) 15611139,Prognostic significance of bcl-2 and p53 expression in colorectal carcinoma.(Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.) 16358373,Inhibition of HDM2 and activation of p53 by ribosomal protein L23.(Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, USA.) 15314174
TP53 (7157) Prives 4 Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription.(Department of Biological Sciences, Columbia University, New York, New York 10027, USA.) 16624812,Mutational analysis of the p53 core domain L1 loop.(Department of Biological Sciences, Columbia University, New York, New York 10027, USA.) 16687402,Transcriptional regulation by p53 and p73.(Department of Biological Sciences, Columbia University, New York, New York 10027, USA.) 16869745
PML (5371) Pandolfi 7 The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage.(Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, USA.) 15626733,The promyelocytic leukaemia protein tumour suppressor functions as a transcriptional regulator of p63.(Department of Pathology, Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.) 16007146,Cytoplasmic PML function in TGF-beta signalling.(Cancer Biology and Genetics Program, Department of Pathology, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, 1275 York Avenue, New York, New York, 10021, USA.) 15356634
PML (5371) Ahn 3 Requirement of the coiled-coil domain of PML-RARalpha oncoprotein for localization, sumoylation, and inhibition of monocyte differentiation.(Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Kyonggido 440-746, Republic of Korea.) 15809060,Ability of the human cytomegalovirus IE1 protein to modulate sumoylation of PML correlates with its functional activities in transcriptional regulation and infectivity in cultured fibroblast cells.(Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, 300 Chunchundong Jangangu, Suwon, Kyonggido 440-746, Korea.) 15163746,Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase.(College of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Korea.) 15273249
PML (5371) Chang 3 A role for PML3 in centrosome duplication and genome stability.(Department of Molecular Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.) 15749021,Promyelocytic leukemia protein 4 induces apoptosis by inhibition of survivin expression.(Department of Molecular Pathology and Department of Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.) 14597622,Androgen suppresses PML protein expression in prostate cancer CWR22R cells.(George Whipple Lab for Cancer Research, Department of Pathology, The Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA.) 14715247
PML (5371) Leppard 2 Interaction of the adenovirus type 5 E4 Orf3 protein with promyelocytic leukemia protein isoform II is required for ND10 disruption.(Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.) 16501113,Isoforms of the promyelocytic leukemia protein differ in their effects on ND10 organization.(Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, U.K.) 15922731
PML (5371) Ley 2 Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells.(Departments of Medicine and Genetics, Division of Oncology, Siteman Cancer Center, Washington University, 660 S. Euclid Ave., Campus Box 8007, St. Louis, MO 63110-1093, USA. ude.ltsuw.mi|yelt#ude.ltsuw.mi|yelt) 15601827,Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.(Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.) 16113082
NFKB1 (4790) Kim 6 Nuclear factor-kappaB activated by capacitative Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells.(Research Institute of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.) 16490783,Transcriptional regulation of human CC chemokine CCL15 gene by NF-kappaB and AP-1 elements in PMA-stimulated U937 monocytoid cells.(Graduate School of Biotechnology and Institute of Life Sciences and Resources, Kyung Hee University, Yongin 449-701, Korea.) 16364464,Dimethylsulfoxide induces upregulation of tumor suppressor protein PTEN through nuclear factor-kappaB activation in HL-60 cells.(Department of Biochemistry, Chonbuk National University Medical School, Chonju 560-182, Republic of Korea.) 15725474
NFKB1 (4790) Lin 4 17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway.(Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA.) 16424045,Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation.(Deptartment of Molecular and Cellular Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, Texas 77030, USA.) 16543241,TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation.(Department of Molecular and Cellular Oncology, Department of Immunology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030, USA.) 16260783
NFKB1 (4790) Shu 3 Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.(Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA. gro.cjn|huhs#gro.cjn|huhs) 14739303,Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB.(Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA.) 14769797,PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis.(National Jewish Medical and Research Center, 1400 Jackson Street, k516c, Denver, CO 80206, USA.) 15251447
NFKB1 (4790) Chiao 3 Identification of an autoregulatory feedback pathway involving interleukin-1alpha in induction of constitutive NF-kappaB activation in pancreatic cancer cells.(Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.) 14679213,Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB.(Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.) 15102862,NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity.(Department of Surgical Oncology, Box 107, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.) 15314185
NFKB1 (4790) Miyamoto 3 NFKB1 is a direct target of the TAL1 oncoprotein in human T leukemia cells.(Program in Molecular and Cellular Pharmacology, Department of Pharmacology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.) 16778171,PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress.(Program in Molecular and Cellular Pharmacology, Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA.) 16906147,Enhanced G2-M arrest by nuclear factor-{kappa}B-dependent p21waf1/cip1 induction.(Department of Pharmacology, University of Wisconsin, 301 Service Memorial Institute, 1300 University Avenue, Madison, WI 53706, USA.) 15972853
NFKB1 (4790) Weiner 3 The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 16429131,HIV-1 Vpr and anti-inflammatory activity.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.) 15142381,HIV-1 Vpr: enhancing sensitivity of tumors to apoptosis.(Dept. of Pathology and Lab. Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 16305395
NFKB1 (4790) Greene 3 NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation.(Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA.) 16319923,Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement.(Gladstone Institute of Virology and Immunology, University of California, 94158, USA.) 16237100,p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1.(Gladstone Institute of Virology and Immunology and the Department of Medicine, University of California, San Francisco, California 94143-1234, USA.) 15073170
NFKB1 (4790) Brown 2 Intracellular inhibitory effects of Velcade correlate with morphoproteomic expression of phosphorylated-nuclear factor-kappaB and p53 in breast cancer cell lines.(Weis Center for Research, Geisinger Medical Center, Danville, Pennsylvania 17822, USA.) 15830705,Overexpression of phosphorylated nuclear factor-kappa B in tonsillar squamous cell carcinoma and high-grade dysplasia is associated with poor prognosis.(Division of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822-0131, USA.) 15920558
NFKB1 (4790) Perkins 2 Differential regulation of NF-kappaB activation and function by topoisomerase II inhibitors.(School of Life Sciences, Division of Gene Regulation and Expression, MSI/WTB, Complex, Dow Street, University of Dundee, Dundee, DD1 5EH, Scotland, UK. ku.ca.eednud|llebpmac.j.k#ku.ca.eednud|llebpmac.j.k) 16630341,Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.(School of Life Sciences, Division of Gene Regulation and Expression, MSI/WTB Complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.) 15053878
NFKB1 (4790) Aggarwal 2 Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.(Cytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, the University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.) 16624823,Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis.(Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.) 15090542
MITF (4286) Fisher 6 c-Met expression is regulated by Mitf in the melanocyte lineage.(Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.) 16455654,Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.(Melanoma Program in Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.) 16766266,Sumoylation of MITF and its related family members TFE3 and TFEB.(Dana-Farber Cancer Institute and Children's Hospital, Department of Pediatric Hematology/Oncology, Melanoma Program in Medical Oncology, Harvard Medical School, Boston, Massachusetts 02115, USA.) 15507434
MITF (4286) Sellers 2 From integrated genomics to tumor lineage dependency.(Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. ude.dravrah.icfd|yawarraG_iveL#ude.dravrah.icfd|yawarraG_iveL) 16510564,Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.(Department of Medical Oncology, and Melanoma Program in Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA.) 16001072
RUNX3 (864) Ito 5 RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells.(Oncology Research Institute, National University Medical Institutes, Institute of Molecular and Cell Biology, Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117592, Singapore.) 16373335,Expression of RUNX3 protein in human esophageal mucosa and squamous cell carcinoma.(Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Yonago, Japan.) 16582583,Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer.(Graduate School of Medical Science, Surgery and Regenerative Medicine, Surgery and Physiology of Digestive System, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kawaramachi-dori, Kyoto 602, Japan. pj.ca.m-upk.otok|arukakas#pj.ca.m-upk.otok|arukakas) 15386419
RUNX3 (864) Bae 3 RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD.(Department of Biochemistry, School of Medicine, and Institute for Tumor Research, Chungbuk National University, Cheongju 361-763, South Korea.) 16135801,Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer.(Department of Biochemistry, School of Medicine and Institute for Tumor Research, Chungbuk National University, Cheongju, Republic of Korea.) 14715269,Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.(Department of Biochemistry and Urology, School of Medicine and Institute for Tumor Research, Chungbuk National University, Cheongju 361-763, South Korea.) 15138260
RUNX3 (864) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
AR (367) Chang 5 Androgen receptor (AR) NH2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growth.(The George H. Whipple Laboratory for Cancer Research, Department of Pathology, and the Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA.) 15514032,Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells.(George H. Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA.) 14966297,Regulation of interleukin-6-mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells.(George H. Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, New York 14642, USA.) 15129430
AR (367) Knudsen 4 Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation.(Department of Cell Biology, University of Cincinnati, Cincinnati, OH 45267, USA.) 16461912,Cyclin D1 binding to the androgen receptor (AR) NH2-terminal domain inhibits activation function 2 association and reveals dual roles for AR corepression.(Department of Cell Biology, University of Cincinnati College of Medicine, P.O. Box 670521, 3125 Eden Avenue, Cincinnati, Ohio 45267-0521, USA.) 15539430,A central domain of cyclin D1 mediates nuclear receptor corepressor activity.(Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0521, USA.) 15558026
AR (367) Giwercman 4 Androgen receptor gene GGN repeat length and reproductive characteristics in young Swedish men.(Molecular Reproductive Medicine Research Unit, Department of Clinical Sciences, Lund University, Fertility Centre, Malmö University Hospital, SE-205 02 Malmö, Sweden.) 16868150,A novel mutation in the D-box of the androgen receptor gene (S597R) in two unrelated individuals Is associated with both normal phenotype and severe PAIS.(Department of Urology, Malmö University Hospital, Lund University, Malmö, Sweden. es.ul.sam.rik|namcrewiG.ennovY#es.ul.sam.rik|namcrewiG.ennovY) 14646391,Androgen receptor gene GGN and CAG polymorphisms among severely oligozoospermic and azoospermic Swedish men.(Fertility Centre, Scanian Andrology Centre, Malmö, Sweden. es.ul.sam.rik|leyahur.risay#es.ul.sam.rik|leyahur.risay) 15229204
AR (367) Zajac 3 Novel androgen receptor gene mutations in Australian patients with complete androgen insensitivity syndrome.(Department of Medicine (AH/NH), University of Melbourne, Austin Health, Heidelberg, VIC 3084, Australia. ua.ude.bleminu|naelcamh#ua.ude.bleminu|naelcamh) 14974091,Polymorphic CAG repeat length in the androgen receptor gene and association with neurodegeneration in a heterozygous female carrier of Kennedy's disease.(Centre for Hormone Research, Murdoch Childrens Research Institute, University of Melbourne Royal Children's Hospital, Flemington Road, Parkville, Melbourne, Victoria 3052, Australia.) 14999487,Increased frequency of long androgen receptor CAG repeats in male breast cancers.(Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, VIC, 3084, Australia. ua.ude.bleminu|naelcamh#ua.ude.bleminu|naelcamh) 15609126
AR (367) Wilson 3 Probing the functional link between androgen receptor coactivator and ligand-binding sites in prostate cancer and androgen insensitivity.(Laboratory for Reproductive Biology, Lineberger Comprehensive Cancer Center, Department of Pediatrics, Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.) 16365032,Epidermal growth factor increases coactivation of the androgen receptor in recurrent prostate cancer.(Laboratories for Reproductive Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599-7500, USA.) 14662770,An androgen receptor NH2-terminal conserved motif interacts with the COOH terminus of the Hsp70-interacting protein (CHIP).(Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.) 15107424
AR (367) Bhasin 2 Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men.(Division of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.) 15522925,Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment.(Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA.) 15472231
AR (367) Hughes 2 Five novel androgen receptor gene mutations associated with complete androgen insensitivity syndrome.(Department of Paediatrics, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom. if.uku|nenialeksaaj.omraj#if.uku|nenialeksaaj.omraj) 16470553,Human androgen receptor gene ligand-binding-domain mutations leading to disrupted interaction between the N- and C-terminal domains.(University Department of Paediatrics, Addenbrooke's Hospital, University of Cambridge, Hills Road CB2 2QQ, UK.) 16595706
AR (367) Foresta 2 Androgen receptor gene CAG and GGC repeat lengths in cryptorchidism.(University of Padova, Department of Histology, Microbiology, and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, 35121 Padova, Italy.) 15757859,Androgen receptor gene CAG and GGC repeat lengths in idiopathic male infertility.(University of Padova, Department of Medical and Surgical Sciences, Centre for Male Gamete Cryopreservation, Padova, Italy.) 15044606
AR (367) Tsai 2 Association study of androgen receptor CAG repeat polymorphism and male violent criminal activity.(Department of Psychiatry, General Psychiatry Section, Taipei Veterans General Hospital, No. 201 Shih-Pai Road Sec. 2, Taipei 11217, Taiwan, ROC.) 16377095,The E3 ubiquitin ligase CHIP binds the androgen receptor in a phosphorylation-dependent manner.(Program in Structural and Computational Biology and Molecular Biophysics, One Baylor Plaza, Baylor College of Medicine, Houston, TX 77030, USA.) 16725394
AR (367) Isaacs 2 PC3, but not DU145, human prostate cancer cells retain the coregulators required for tumor suppressor ability of androgen receptor.(Chemical Therapeutics Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.) 16835890,Molecular characterization of the commonly used human androgen receptor expression vector, pSG5-AR.(The Sidney Kimmel Comprehensive Cancer Center, the Graduate Training Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.) 14968432
HIF1A (3091) Park 5 The zinc chelator, N,N,N',N'-tetrakis (2-pyridylmethyl) ethylenediamine, increases the level of nonfunctional HIF-1alpha protein in normoxic cells.(Department of Life Science, University of Seoul, 90 Cheonnong-dong, Tongdaemun-gu, Seoul 130-743, Republic of Korea.) 16579968,Differential responses of two degradation domains of HIF-1alpha to hypoxia and iron deficiency.(Department of Pharmacology, Seoul National University College of Medicine, 28, Yongon-dong, Chongno-gu, Seoul 110-799, South Korea.) 16139409,Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinoma.(Division of Hematology/Oncology, Department of Medicine, Samsung Medical Center, Ilwon-Dong 50, Gangnam-Gu, Seoul 135-710, Korea.) 15809750
HIF1A (3091) Brüne 5 Reactive oxygen species attenuate nitric-oxide-mediated hypoxia-inducible factor-1alpha stabilization.(Institute of Biochemistry I, Faculty of Medicine, Johann Wolfgang Goethe-University, Frankfurt, Germany.) 16631533,Calpain mediates a von Hippel-Lindau protein-independent destruction of hypoxia-inducible factor-1alpha.(Institute of Biochemistry I, Faculty of Medicine, Johann Wolfgang Goethe-University Frankfurt, 60590 Frankfurt, Germany.) 16421254,Retinoblastoma susceptibility gene product pRB activates hypoxia-inducible factor-1 (HIF-1).(Department of Medicine IV-Experimental Division, Faculty of Medicine, University of Erlangen-Nürnberg, 91054 Erlangen, Germany.) 15674338
HIF1A (3091) Kim 4 Tid-1 interacts with the von Hippel-Lindau protein and modulates angiogenesis by destabilization of HIF-1alpha.(Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea.) 15805242,Negative regulation of hypoxia inducible factor-1alpha by necdin.(Neurovascular Coordination Research Center and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.) 15978586,Epigallocatechin gallate inhibits HIF-1alpha degradation in prostate cancer cells.(Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA.) 16005427
HIF1A (3091) Huang 4 HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.(Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.) 15780936,Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1.(Laboratory of Human Carcinogenesis, NCI, National Institutes of Health, Bethesda, MD 20892, USA.) 16157596,HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.(Laboratory of Human Carcinogenesis, NCI, National Institutes of Health, Bethesda, MD 20892, USA.) 15071503
HIF1A (3091) van Diest 3
HIF1A (3091) Harris 3 The relation between hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression with anemia and outcome in surgically treated head and neck cancer.(Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.) 16826581,The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer.(Harold Hopkins Department of Urology, Royal Berkshire Hospital, Reading, UK.) 16278385,CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha.(Nuffield Department Clinical Laboratory Sciences, John Radcliffe Hospital and Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, Henry Wellcome Building of Genomic Medicine, University of Oxford, UK. ku.ca.xo.slcdn|xof.nehpets#ku.ca.xo.slcdn|xof.nehpets) 15342390
HIF1A (3091) Semenza 3 Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.(Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.) 15374877,OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.(Institute for Cell Engineering, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.) 15721254,Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling.(Department of Anesthesia, The Tazuke Kofukai Medical Research Institute Kitano Hospital, 2-4-20, Ohgimachi, Kita-ku, Osaka 530-8480, Japan. moc.cam|1fih#moc.cam|1fih) 15280370
HIF1A (3091) Fandrey 2 Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB.(Institut für Physiologie, Universität Duisburg-Essen Hufelandstrasse 55, D-45122 Essen, Federal Republic of Germany.) 16533170,Chelation of cellular calcium modulates hypoxia-inducible gene expression through activation of hypoxia-inducible factor-1alpha.(Institut für Physiologie, Universität Duisburg-Essen, Hufelandstrasse 55, D-45122 Essen, Germany.) 15322093
HIF1A (3091) Caniggia 2 Dynamic HIF1A regulation during human placental development.(Department of Obstetrics and Gynecology, Mount Sinai Hospital, and Department of Physiology, University of Toronto, Ontario, Canada.) 16611863,Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1.(Mount Sinai Hospital, Department of Obstetrics, University of Toronto, Canada.) 16627691
HIF1A (3091) Maity 2 Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway.(Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.) 16849522,Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism.(Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19004, USA.) 15342781
ESR1 (2099) Safe 5 Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.(Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, College Station, Texas 77843-4466, USA.) 16675542,Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins.(Department of Biochemistry, Texas A&M University, College Station, 77843-4466, USA.) 16574784,DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs.(Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas 77843-4466, USA.) 15625066
ESR1 (2099) Kato 4 Splicing potentiation by growth factor signals via estrogen receptor phosphorylation.(Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan.) 15919818,Repressive domain of unliganded human estrogen receptor alpha associates with Hsc70.(The Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo-ku, Japan.) 16324147,Wnt/beta-catenin and estrogen signaling converge in vivo.(The Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.) 15304487
ESR1 (2099) Gustafsson 4 Estrogen receptor (ER) beta modulates ERalpha-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen-responsive promoters.(Department of Biosciences at Novum, Karolinska Institutet, Huddinge 14157, Sweden. es.ik.icsoib|swehttam.nosaj#es.ik.icsoib|swehttam.nosaj) 16293641,Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters.(Department of Biosciences at Novum, Karolinska Institutet, Novum 14157, Sweden. es.ik.icsoib|swehttam.nosaj#es.ik.icsoib|swehttam.nosaj) 15964790,Estrogen receptor-alpha regulates SOCS-3 expression in human breast cancer cells.(Department of Biosciences at Novum, Karolinska Institutet, Novum, S-14157 Huddinge, Sweden. es.ik.icsoib|swehttam.nosaj#es.ik.icsoib|swehttam.nosaj) 16055089
ESR1 (2099) Brown 4 Global gene expression analysis of estrogen receptor transcription factor cross talk in breast cancer: identification of estrogen-induced/activator protein-1-dependent genes.(Department of Medicine, Baylor Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA.) 15514030,Cell cycle progression stimulated by tamoxifen-bound estrogen receptor-alpha and promoter-specific effects in breast cancer cells deficient in N-CoR and SMRT.(Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, D730, Boston, Massachusetts 02115, USA.) 15802375,Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1.(Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA.) 16009131
ESR1 (2099) Marino 4 Survival versus apoptotic 17beta-estradiol effect: role of ER alpha and ER beta activated non-genomic signaling.(Department of Biology, University Roma Tre, Rome, Italy.) 15389627,Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol.(Department of Biology, University Roma Tre, I-00146 Rome, Italy.) 15496458,S-palmitoylation modulates human estrogen receptor-alpha functions.(Department of Biology, University Roma Tre, Viale G. Marconi, 446, I-00146, Rome, Italy.) 15033483
ESR1 (2099) Andò 4 Endogenous coactivator ARA70 interacts with estrogen receptor alpha (ERalpha) and modulates the functional ERalpha/androgen receptor interplay in MCF-7 cells.(Department of Pharmacobiology, University of Calabria, 87036 Arcavacata di Rende (CS), Italy.) 15772083,The red wine phenolics piceatannol and myricetin act as agonists for estrogen receptor alpha in human breast cancer cells.(Department of Pharmaco-Biology, University of Calabria, Rende (Cs), Italy.) 16216908,Estrogen receptor (ER)alpha and ER beta are both expressed in human ejaculated spermatozoa: evidence of their direct interaction with phosphatidylinositol-3-OH kinase/Akt pathway.(Centro Sanitario, University of Calabria 87030 Arcavacata di Rende, Cosenza, Italy. ti.orebil|vasiuqa#ti.orebil|vasiuqa) 15001646
ESR1 (2099) Uitterlinden 4 Estrogen receptor alpha gene polymorphisms and anxiety disorder in an elderly population.() 15940291,Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women.(Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.) 16061840,Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction.(Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.) 15213208
ESR1 (2099) Kumar 4 Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells.(Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.) 16684779,Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway.(Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.) 15169784,Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor alpha in breast cancer cells.(Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.) 15173068
ESR1 (2099) Lee 3 New role for nuclear hormone receptors and coactivators in regulation of BRCA1-mediated DNA repair in breast cancer cell lines.(Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA. ude.csu|eworcd#ude.csu|eworcd) 16417649,Loss of estrogen receptor-alpha expression is associated with hypermethylation near its ATG start codon in gastric cancer cell lines.(Department of Internal Medicine, College of Medicine, Catholic University, Seoul 137-040, Korea. rk.ca.cilohtac|oowkoosni#rk.ca.cilohtac|oowkoosni) 14767512,Association of estrogen receptor 1 intron 1 C/T polymorphism in Korean vitiligo patients.(Department of Pharmacology, College of Medicine, Kohwang Medical Research Institute, Kyung Hee University, Seoul 130-701, South Korea.) 15381239
ESR1 (2099) Griffiths 3 Detection of mRNA levels for the estrogen alpha, estrogen beta and androgen nuclear receptor genes in archival breast cancer tissue.(Genomics Research Centre and Wesley Research Institute, School of Health Science, Griffith University Gold Coast, PMB 50 Gold Coast Mail Centre, Qld. 9726, Australia.) 16046054,No role for estrogen receptor 1 gene intron 1 Pvu II and exon 4 C325G polymorphisms in migraine susceptibility.(Genomics Research Centre, School of Health Science, Griffith University Gold Coast, PMB 50, Gold Coast Mail Centre, Queensland, 9726, Australia. ua.ude.htiffirg|nosloc.n#ua.ude.htiffirg|nosloc.n) 16504171,The estrogen receptor 1 G594A polymorphism is associated with migraine susceptibility in two independent case/control groups.(Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Queensland, Australia.) 15133719
NR1H4 (9971) Edwards 4 FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.(Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.) 16251721,Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling.(Department of Biological Chemistry and Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.) 15604525,Alpha-crystallin is a target gene of the farnesoid X-activated receptor in human livers.(Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.) 16012168
NR1H4 (9971) Burris 2 Regulation of carbohydrate metabolism by the farnesoid X receptor.(Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.) 15564327,Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor.(Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, IN 46285, USA.) 15721319
NR1H4 (9971) Jingami 2 The region of CQQQKPQRRP of PGC-1alpha interacts with the DNA-binding complex of FXR/RXRalpha.(Department of Molecular Biology, Biomolecular Engineering Research Institute (BERI), Osaka, Japan.) 16494845,The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner.(Department of Molecular Biology, Biomolecular Engineering Research Institute (BERI), 6-2-3 Furuedai, Suita-City, Osaka 565-0874, Japan.) 15202934
KLF4 (9314) Yang 4 Transcriptional profiling of the cell cycle checkpoint gene krüppel-like factor 4 reveals a global inhibitory function in macromolecular biosynthesis.(Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.) 17017123,Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage.(Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.) 15806166,Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage.(Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.) 14627709
KLF4 (9314) Ruppert 2 Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia.(Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.) 15674344,Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer.(Department of Cell Biology, University of Alabama at Birmingham, 35294, USA.) 15102675
GCM1 (8521) Chen 4 Histone deacetylase 3 binds to and regulates the GCMa transcription factor.(Graduate Institute of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan.) 16528103,FBW2 targets GCMa to the ubiquitin-proteasome degradation system.(Graduate Institute of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan.) 15640526,Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa.(Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan.) 16166624
GCM1 (8521) Hashemolhosseini 2 Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions.(University Hospital for Children and Adolescents, University of Erlangen-Nuremberg, Germany.) 16004993,Interaction, cooperative promoter modulation, and renal colocalization of GCMa and Pitx2.(Institut für Biochemie, Universität Erlangen-Nürnberg, Fahrstrasse 17, D-91054 Erlangen, Germany.) 15385555
LHX3 (8022) Rhodes 4 Two promoters mediate transcription from the human LHX3 gene: involvement of nuclear factor I and specificity protein 1.(Department of Biology (B.C.Y., M.G.), Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202, USA.) 16179410,Clinical case seminar: a novel LHX3 mutation presenting as combined pituitary hormonal deficiency.(Pediatric Endocrinology Division, Infant's and Children's Hospital of Brooklyn at Maimonides, Brooklyn, New York 11219, USA.) 16394081,Serine/threonine/tyrosine phosphorylation of the LHX3 LIM-homeodomain transcription factor.(Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202-5132, USA.) 15517599
WT1 (7490) Sugiyama 4 Antiapoptotic function of 17AA(+)WT1 (Wilms' tumor gene) isoforms on the intrinsic apoptosis pathway.(Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.) 16518414,Th1-biased humoral immune responses against Wilms tumor gene WT1 product in the patients with hematopoietic malignancies.(Department of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.) 15538407,Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression.(Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.) 15365188
WT1 (7490) Roberts 2 BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1.(School of Biological Sciences, University of Manchester, G.186 Stopford Building, Oxford Road, Manchester M13 9PT, UK.) 14701728,Transcriptional regulation by the Wilms' tumour suppressor protein WT1.(School of Biological Sciences, The Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK.) 15506928
WT1 (7490) Yasukawa 2 Direct recognition and lysis of leukemia cells by WT1-specific CD4+ T lymphocytes in an HLA class II-restricted manner.(First Department of Internal Medicine, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan.) 15845894,Myeloma cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes.(First Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan.) 15534117
SP1 (6667) Hung 4 HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion.(Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.) 16377629,p16 inhibits matrix metalloproteinase-2 expression via suppression of Sp1-mediated gene transcription.(Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.) 16575904,1,25-dihydroxyvitamin D3 transcriptionally represses p45Skp2 expression via the Sp1 sites in human prostate cancer cells.(Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, China.) 16883603
SP1 (6667) Kim 3 Transcription factor Sp1 mediates p38MAPK-dependent activation of the p21WAF1 gene promoter in vascular smooth muscle cells by pyrrolidine dithiocarbamate.(National Research Laboratory for Glycobiology, Korean Ministry of Science and Technology, Kyungju, Kyungbuk 780-714, Republic of Korea.) 15033443,Sp1-dependent regulation of the RTP801 promoter and its application to hypoxia-inducible VEGF plasmid for ischemic disease.(Clinical Research Center, College of Medicine, Inha University, Inchon 400-711, Korea.) 15180327,Regulatory elements involved in transcription of the human NeuAcalpha2,3Galbeta1,3GalNAcalpha2,6-sialyltransferase (hST6GalNAc IV) gene.(National Research Laboratory for Glycobiology, Department of Biochemistry and Molecular Biology, College of Oriental Medicine, Dongguk University, Kyungju 780-714, Korea.) 15528990
SP1 (6667) Safe 3 Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.(Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, College Station, Texas 77843-4466, USA.) 16675542,Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer.(Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, Veterinary Research Building 409, College Station, Texas 77843-4466, USA.) 15637147,Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins.(Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, Texas 77030, USA.) 15345676
SP1 (6667) St Clair 2
SP1 (6667) Chang 2 O-linked N-acetylglucosamine suppresses thermal aggregation of Sp1.(School of Life Sciences and Biotechnology, Korea University, 5-1 Anam-dong, Seongbuk-gu, Seoul 136-701, Republic of Korea.) 16879824,Hsp90alpha recruited by Sp1 is important for transcription of 12(S)-lipoxygenase in A431 cells.(Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.) 16118214
SP1 (6667) Tamaki 2 Platelet derived growth factor induced tenascin-C transcription is phosphoinositide 3-kinase/Akt-dependent and mediated by Ets family transcription factors.(Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.) 16245312,Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1.(Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.) 15001984
SP1 (6667) Robertson 2 Expression of alpha V integrin is modulated by Epstein-Barr virus nuclear antigen 3C and the metastasis suppressor Nm23-H1 through interaction with the GATA-1 and Sp1 transcription factors.(Department of Microbiology, The Tumor Virology Program of the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 16631833,Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1.(Department of Microbiology and Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 15367601
SP1 (6667) Sawaya 2 Human immunodeficiency virus type 1 Tat prevents dephosphorylation of Sp1 by TCF-4 in astrocytes.(Department of Neuroscience & Center for Neurovirology, Temple University School of Medicine, 1900 N 12th Street (015-96), Philadelphia, PA 19122, USA.) 16690926,Interplay between HIV-1 Vpr and Sp1 modulates p21(WAF1) gene expression in human astrocytes.(Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA.) 15302882
SP1 (6667) Xie 2 Altered expression of transcription factor Sp1 critically impacts the angiogenic phenotype of human gastric cancer.(Shanghai East Hospital Cancer Center, Tongji University, Shanghai, The People's Republic of China.) 16158248,Association between expression of transcription factor Sp1 and increased vascular endothelial growth factor expression, advanced stage, and poor survival in patients with resected gastric cancer.(Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.) 15217947
SP1 (6667) Shih 2 Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1.(Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California 90033, USA.) 16728402,Dual functions of transcription factors, transforming growth factor-beta-inducible early gene (TIEG)2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B gene.(Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA.) 15024015
PPARA (5465) Staels 4 Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis.(Département d'Athérosclérose, Institut Pasteur de Lille, INSERM U545, and Université de Lille 2, Lille, France.) 16511589,Peroxisome proliferator-activated receptor alpha controls cellular cholesterol trafficking in macrophages.(UR 545 Inserm, Institut Pasteur de Lille and Université de Lille 2, Lille, France.) 16162941,PPAR alpha inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a.(INSERM U545, Département d'Athérosclérose, Institut Pasteur de Lille et Faculté de Pharmacie, Université Lille II, Lille, France.) 16239970
PPARA (5465) 2
NFKB2 (4791) Xiao 4 Regulation of NF-kappa B2 p100 processing by its cis-acting domain.(Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.) 15485830,Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100.(Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, 604 Allison Rd., Piscataway, New Jersey 08854, USA.) 15677466,Stabilization of basally translated NF-kappaB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100.(Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.) 16223731
NFKB2 (4791) Sun 2 beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870.(Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, P.O. Box 850, Hershey, Pennsylvania 17033, USA.) 16303288,Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation.(Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA. ude.sregtur.ygoloib|oaix#ude.sregtur.ygoloib|oaix) 15140882
NFE2L2 (4780) Yamamoto 4 Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer.(RIKEN Genomic Sciences Center, Tsurumi, Yokohama 230-0045, Japan.) 16507366,Predictive base substitution rules that determine the binding and transcriptional specificity of Maf recognition elements.(Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8577, Japan.) 16716189,Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells.(Environmental Response Project ERATO-Japan Science and Technology Agency, Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan.) 15917255
NFE2L2 (4780) Jaiswal 3 Nuclear factor Nrf2 and antioxidant response element regulate NRH:quinone oxidoreductase 2 (NQO2) gene expression and antioxidant induction.(Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.) 16545679,Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants.(Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA.) 15734732,Nuclear import and export signals in control of Nrf2.(Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA.) 15901726
NFE2L2 (4780) O'Connell 2 Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells.(MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, CB1 9NL, UK.) 16123320,Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C.(Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, United Kingdom.) 16177082
MYC (4609) Levens 4 The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression.(Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892-1500, USA.) 16628215,The CT-element of the c-myc gene does not predispose to chromosomal breakpoints in Burkitt's lymphoma.(Institute of Pathology, Johannes Gutenberg-University of Mainz, Langenbeckstr. 1, 55101 Mainz, Germany. ed.zniam-inu.kinilk.eigolohtap|rebew#ed.zniam-inu.kinilk.eigolohtap|rebew) 16675879,TFIIH operates through an expanded proximal promoter to fine-tune c-myc expression.(Gene Regulation Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute/NIH, Bldg. 10, Rm. 2N106, Bethesda, MD 20892-1500, USA.) 15601838
MYC (4609) Dang 3 Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis.(Program in Human Genetics and Molecular Biology, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.) 16508012,Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis.(Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.) 15988031,Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays.(Graduate Program of Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.) 15199147
MYC (4609) Wang 3 Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter region.(Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.) 16706751,Polyamine-modulated expression of c-myc plays a critical role in stimulation of normal intestinal epithelial cell proliferation.(Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.) 15355849,c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts.(The Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, The Sir Mortimer B. Davis-Jewish General Hospital, and Department of Medicine, McGill University, Montréal, Québec, Canada.) 16167342
MYC (4609) Huang 3 HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.(Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.) 15780936,IL-5 inhibits apoptosis by upregulation of c-myc expression in human hematopoietic cells.(Graduate Institute of Medical Sciences, Taipei Medical University, Hsinyi District, Taipei 110, Taiwan.) 15965094,HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.(Laboratory of Human Carcinogenesis, NCI, National Institutes of Health, Bethesda, MD 20892, USA.) 15071503
MYC (4609) Johnson 2 ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.(Department of Carcinogenesis, University of Texas M. D. Anderson Cancer Center, Science Park Research Division, 1808 Park Road 1C, Smithville, TX 78957, USA.) 16432227,Oncogenes and the DNA damage response: Myc and E2F1 engage the ATM signaling pathway to activate p53 and induce apoptosis.(The University of Texas MD Anderson Cancer Center, Science Park Research Division, Department of Carcinogenesis, Smithville, Texas, USA.) 16582589
MYC (4609) León 2 Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway.(Grupo de Biología Molecular del Cáncer, Departamento de Biología Molecular, Unidad de Biomedicina del Consejo Superior de Investigaciones Cientiíficas, Facultad de Medicina, Universidad de Cantabria, 39011 Santander, Spain.) 15528212,Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes.(Departamento de Biología Molecular y Unidad de Biomedicina-CSIC, Grupo de Biología Molecular del Cáncer, Facultad de Medicina, University of Cantabria, Santander 39011, Spain.) 15856024
MYC (4609) Leffak 2 Differential binding of replication proteins across the human c-myc replicator.(Department of Biochemistry and Molecular Biology, Wright State University, 3640 Colonel Glenn Highway, Dayton, Ohio 45435, USA.) 16809765,Transcription factor binding and induced transcription alter chromosomal c-myc replicator activity.(Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA.) 15542830
MYC (4609) Jung 2 c-Myc over-expression in Ramos Burkitt's lymphoma cell line predisposes to iron homeostasis disruption in vitro.(Héma-Québec, Recherche et Développement, 1009 route du Vallon, Sainte-Foy, Quebec, Canada G1V 5C3.) 16466700,Iron specific growth inhibition of Burkitt's lymphoma cells in vitro, associated with a decrease in translocated c-myc expression.(Héma-Québec, Recherche et Développement, route du Vallon, Sainte-Foy, Québec, Canada.) 15468060
MYC (4609) Chowdhury 2 Quadruplex-duplex competition in the nuclease hypersensitive element of human c-myc promoter: C to T mutation in C-rich strand enhances duplex association.(Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110007, India.) 15629428,Kinetic resolution of bimolecular hybridization versus intramolecular folding in nucleic acids by surface plasmon resonance: application to G-quadruplex/duplex competition in human c-myc promoter.(Institute of Genomics and Integrative Biology, CSIR Mall Road, Delhi 110007, India.) 16085756
MYC (4609) Martinez 2 Six lysine residues on c-Myc are direct substrates for acetylation by p300.(Department of Chemistry, University of California at Riverside, Riverside, CA 92521, USA.) 16126174,Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription.(Department of Biochemistry, University of California Riverside, Riverside, CA 92521, USA.) 16287840
SMAD3 (4088) Liu 4 Transforming growth factor beta suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene.(Department of Immunology and Monash Institute of Medical Research, Monash University, Melbourne, Victoria 3181, Australia.) 16785237,Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3.(Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, USA.) 16156666,Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3).(Center for Advanced Biotechnology and Medicine, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.) 14691252
SMAD3 (4088) Kim 3 A novel E1A-like inhibitor of differentiation (EID) family member, EID-2, suppresses transforming growth factor (TGF)-beta signaling by blocking TGF-beta-induced formation of Smad3-Smad4 complexes.(Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892-5055, USA.) 14612439,Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer.(Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, MD 20892-5055, USA.) 14647420,Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells.(Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, MD 20892-5055, USA.) 15107418
SMAD3 (4088) Wang 3 Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells.(Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.) 16543220,Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathways.(Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA.) 15051726,Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1.(Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA. moc.liamtoh|yrruon_erialc#moc.liamtoh|yrruon_erialc) 15144564
SMAD3 (4088) Okazaki 2 Acceleration of Smad2 and Smad3 phosphorylation via c-Jun NH(2)-terminal kinase during human colorectal carcinogenesis.(Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan.) 15665291,TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions.(Third Department of Internal Medicine, Kansai Medical University, 10-15 Fumizonocho, Moriguchi, Osaka 570-8507, Japan.) 15326485
SMAD3 (4088) Souchelnytskyi 2 TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage.(Ludwig Institute for Cancer Research, Box 595, Biomedical Center, SE-751 24 Uppsala, Sweden.) 15735739,Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity.(Ludwig Institute for Cancer Research, Box 595, BMC, SE-751 24, Uppsala, Sweden.) 15527767
ID1 (3397) Wong 4 Proteasome mediated degradation of Id-1 is associated with TNFalpha-induced apoptosis in prostate cancer cells.(Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China.) 16123120,Inactivation of Id-1 in prostate cancer cells: A potential therapeutic target in inducing chemosensitization to taxol through activation of JNK pathway.(Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong.) 16287090,Overexpression of Id-1 in prostate cancer cells promotes angiogenesis through the activation of vascular endothelial growth factor (VEGF).(Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China.) 15905202
ID1 (3397) Cheung 2 Id-1 promotes proliferation of p53-deficient esophageal cancer cells.(Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.) 16506209,Id helix-loop-helix proteins are differentially expressed in gestational trophoblastic disease.(Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.) 16115231
ID1 (3397) Schwartz 2 E12 and E47 modulate cellular localization and proteasome-mediated degradation of MyoD and Id1.(Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA.) 16007194,Ubiquitin-Proteasome-mediated degradation of Id1 is modulated by MyoD.(Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St. Louis Children's Hospital, Missouri 63110, USA.) 15163661
HOXA10 (3206) Taylor 4 HOXA10 expression in ectopic endometrial tissue.(Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA.) 16647375,Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells.(Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA.) 15905361,A HOXA10 estrogen response element (ERE) is differentially regulated by 17 beta-estradiol and diethylstilbestrol (DES).(Yale University School of Medicine, Division of Reproductive Endocrinology, P.O. Box 208063, 333 Cedar Street, New Haven, CT 06520-8063, USA.) 15236964
HOXA10 (3206) Humphries 2 The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia.(Terry Fox Laboratory, British Columbia Cancer Agency, 11th Floor, 675 West 10th Ave, Vancouver, BC, Canada V5Z 1L3.) 16861351,Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1.(Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver V5Z 1L3, Canada.) 14966272
HIC1 (3090) Leprince 4 [Chromosome arm 17p13.3: could HIC1 be the one ?](ERI-8 Inserm, Signalisation des facteurs de croissance dans le cancer du sein, Protéomique fonctionnelle, UPRES EA 1033, IFR 118, Bâtiment SN3, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France. rf.1ellil-vinu|nipohc.eirelav#rf.1ellil-vinu|nipohc.eirelav) 16386221,A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP.(CNRS UMR 8526, Institut de Biologie de Lille, Institut Pasteur de Lille, France.) 16762039,Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1.(CNRS UMR 8526, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 Rue Calmette, 59017 Lille, France.) 15007385
NR3C1 (2908) Vedeckis 4 Interaction between the interferon signaling pathway and the human glucocorticoid receptor gene 1A promoter.(Department of Biochemistry and Molecular Biology and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, 533 Bolivar Street, New Orleans, Louisiana 70112, USA.) 15576464,Human glucocorticoid receptor alpha transcript splice variants with exon 2 deletions: evidence for tissue- and cell type-specific functions.(Department of Biochemistry and Molecular Biology and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.) 15895983,c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter.(Department of Biochemistry and Molecular Biology and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.) 16263717
NR3C1 (2908) Chrousos 3 A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity.(Department of Pediatric Endocrinology, Great Ormond Street Hospital for Children, 9th Floor, Southwood Building, Great Ormond Street, London, United Kingdom WC1N 3JH. vog.hin.liam|enamrahc#vog.hin.liam|enamrahc) 15769988,G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus.(Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. vog.hin.liam|tonik#vog.hin.liam|tonik) 15955845,Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?(Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1583, USA. vog.hin.liam|tonik#vog.hin.liam|tonik) 15265780
NR3C1 (2908) Kino 2 The human glucocorticoid receptor (hGR) beta isoform suppresses the transcriptional activity of hGRalpha by interfering with formation of active coactivator complexes.(Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Building 10, Room 9D42, Bethesda, Maryland 20892-1583, USA. vog.hin.liam|enamrahc#vog.hin.liam|enamrahc) 15459252,Intracellular glucocorticoid signaling: a formerly simple system turns stochastic.(Department of Pediatrics, University of Athens, Athens 115 27, Greece. rg.aou.dem|egsuorhc#rg.aou.dem|egsuorhc) 16204701
NR3C1 (2908) Lamberts 2 Glucocorticoid receptor polymorphism affects transrepression but not transactivation.(Erasmus Medical Center, Department of Internal Medicine, Room Ee 585, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.) 16684836,The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults.(Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. ln.cmsumsare|mussornav.e#ln.cmsumsare|mussornav.e) 15292341
NR3C1 (2908) Weiner 2 The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 16429131,Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 15832179
NR3C1 (2908) Cidlowski 2 Functional analysis of the LXXLL motifs of the human glucocorticoid receptor: association with altered ligand affinity.(Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, United States.) 16914312,Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes.(Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.) 15866175
NR3C1 (2908) Yamamoto 2 The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression.(Department of Cellular and Molecular Pharmacology, University of California-San Francisco, San Francisco, CA 94107-2280, USA.) 15879558,Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes.(Departments of Cellular and Molecular Pharmacology and Medicine, University of California-San Francisco, S572D, Genentech Hall, 600 16th Street, San Francisco, CA 94107-2280, USA.) 15501915
NR3C1 (2908) Stangl 2 The pregnancy hormone relaxin binds to and activates the human glucocorticoid receptor.(Charité Berlin, Campus Mitte, Medizinische Klinik m. S. Kardiologie, Angiologie und Pulmologie, Schumannstr. 20/21, 10117 Berlin, Germany. ed.enilno-t|gizteihcsd.samoht#ed.enilno-t|gizteihcsd.samoht) 15956716,Identification of the pregnancy hormone relaxin as glucocorticoid receptor agonist.(Medizinische Klinik m. S. Kardiologie, Angiologie, Pulmologie, Charité Berlin, Berlin, Germany. ed.enilno-t|gizteihcsd.samoht#ed.enilno-t|gizteihcsd.samoht) 15289446
NR3C1 (2908) Thompson 2 Activation function 1 of glucocorticoid receptor binds TATA-binding protein in vitro and in vivo.(Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555-1068, USA.) 16469772,TATA box binding protein induces structure in the recombinant glucocorticoid receptor AF1 domain.(Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555, USA.) 15545613
FOXC1 (2296) Walter 4 Regulation of FOXC1 stability and transcriptional activity by an epidermal growth factor-activated mitogen-activated protein kinase signaling cascade.(Department of Ophthalmology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada. ac.atreblau|yrrebf#ac.atreblau|yrrebf) 16492674,FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner.(Department of Ophthalmology, University of Alberta, Edmonton, AB, Canada. ac.atreblau|yrrebf#ac.atreblau|yrrebf) 15684392,The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions.(Department of Ophthalmology, University of Alberta, Edmonton, Canada.) 15277473
CEBPD (1052) DeWille 4 Promoter methylation reduces C/EBPdelta (CEBPD) gene expression in the SUM-52PE human breast cancer cell line and in primary breast tumors.(Department of Veterinary Biosciences and Ohio State Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.) 16322893,C/EBPdelta is a downstream mediator of IL-6 induced growth inhibition of prostate cancer cells.(Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.) 15486993,CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control.(Department of Veterinary Biosciences and Division of Molecular Biology and Cancer Genetics, Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.) 15389878
CEBPD (1052) Chang 2 Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene.(Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.) 16397300,Induction of human NF-IL6beta by epidermal growth factor is mediated through the p38 signaling pathway and cAMP response element-binding protein activation in A431 cells.(Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.) 15901830
CEBPD (1052) Koeffler 2 C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation.(Cedars-Sinai Medical Center, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, CA 90048, USA. gro.shsc|syreg#gro.shsc|syreg) 15674331,Protein partners of C/EBPepsilon.(Division of Hematology/Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, Calif. 90048, USA.) 15588942
CDKN2A (1029) Kim 4 Methylation of p16(INK4A) and p57(KIP2) are involved in the development and progression of gastric MALT lymphomas.(Department of Clinical Pathology, The Catholic University of Korea, College of Medicine, Inchon, Korea.) 16357845,The hypermethylation and protein expression of p16 INK4A and DNA repair gene O6-methylguanine-DNA methyltransferase in various uterine cervical lesions.(Department of Pathology, Korea University College of Medicine, Seoul, South Korea.) 15785933,Human papillomavirus genotyping by oligonucleotide microarray and p16 expression in uterine cervical intraepithelial neoplasm and in invasive carcinoma in Korean women.(Department of Pathology, Yanbian University College of Medicine, Yanji, China.) 15998377
CDKN2A (1029) Li 3 Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma.(Department of Oncology, Second Hospital, Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China. nc.moc.oohay|ilambhm#nc.moc.oohay|ilambhm) 15655836,p53 activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF.(Radiation Biology, Division of Radiation Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA.) 14729628,Methylation of p16 CpG islands associated with malignant transformation of gastric dysplasia in a population-based study.(Peking University School of Oncology and Beijing Institute for Cancer Research, Beijing, People's Republic of China.) 15297411
CDKN2A (1029) 3
CDKN2A (1029) Gazzeri 3 p14ARF promotes RB accumulation through inhibition of its Tip60-dependent acetylation.(INSERM U578, Groupe de Recherche sur le Cancer du Poumon, Université Joseph Fourier, Faculté de Medecine, Institut Albert Bonniot, La Tronche Cedex, France.) 16501607,p14ARF triggers G2 arrest through ERK-mediated Cdc25C phosphorylation, ubiquitination and proteasomal degradation.(INSERM U578, Groupe de Recherche sur le Cancer du Poumon, Université Joseph Fourier, La Tronche, France. rf.elbonerg-fju|nimyE.ecirtaeB#rf.elbonerg-fju|nimyE.ecirtaeB) 16582626,p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress.(Groupe de Recherche sur le Cancer du Poumon, INSERM U578, Institut Albert Bonniot, 38706 La Tronche Cedex, France.) 16705183
CDKN2A (1029) Daniel 2 p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity.(Department of Hematology, Oncology and Tumor Immunology, University Medical Center Charité, Campus Berlin-Buch, D-13125 Berlin-Buch, Germany.) 15582998,Loss of p21 disrupts p14 ARF-induced G1 cell cycle arrest but augments p14 ARF-induced apoptosis in human carcinoma cells.(Department of Hematology, Oncology and Tumor Immunology, University Medical Center Charité, Campus Berlin-Buch, Berlin-Buch, Germany.) 15750619
CDKN2A (1029) Bianchi-Scarrà 2 INK4/ARF germline alterations in pancreatic cancer patients.(Dipartimento di Oncologia, Biologia e Genetica (DOBiG), Università degli Studi di Genova, Genova, Italy.) 14679123,Inverse correlation between p16INK4A expression and NF-kappaB activation in melanoma progression.(Department of Oncology, Biology and Genetics, University of Genova, Italy.) 15297971
CDKN2A (1029) Blin 2 Inactivation of the cyclin-dependent kinase inhibitor 2A (CDKN2A) gene in squamous cell carcinoma of the larynx.(Department of Pathophysiology, Wroclaw Medical University, Poland.) 14991744,Impairment of MLH1 and CDKN2A in oncogenesis of laryngeal cancer.(Department of Genetics, Medical University, ul. Marcinkowskiego 1, Wroclaw 50-368, Poland. lp.corw.ma.neg|kedaisas#lp.corw.ma.neg|kedaisas) 15083191
CDKN2A (1029) Leachman 2 Nevus distribution in a Utah melanoma kindred with a temperature-sensitive CDKN2A mutation.() 16354203,Longitudinal assessment of the nevus phenotype in a melanoma kindred.(The Melanoma Program, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112-5550, USA.) 15304099
CDKN2A (1029) Tong 2 Sp1 is involved in the transcriptional activation of p16(INK4) by p21(Waf1) in HeLa cells.(Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, 38 Xueyuan Road, Beijing 100083, PR China.) 15094066,Regulation of cellular senescence and p16(INK4a) expression by Id1 and E47 proteins in human diploid fibroblast.(Department of Biochemistry and Molecular Biology, Peking University, Health Science Center, 38 Xueyuan Road, Beijing 100083, People's Republic of China.) 15138269
CDKN2A (1029) Halloran 2 Increased expression of senescence-associated cell cycle inhibitor p16INK4a in deteriorating renal transplants and diseased native kidney.(Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, Canada. ed.grebldieh-inu.dem|klem.ettena#ed.grebldieh-inu.dem|klem.ettena) 15888044,Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney.(Division of Nephrology and Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. ed.oohay|klemettenna#ed.oohay|klemettenna) 14717921
PHOX2B (8929) Amiel 3 PHOX2B genotype allows for prediction of tumor risk in congenital central hypoventilation syndrome.(Unité de Recherches sur les Handicaps Génétiques de l'Enfant INSERM U-393, Département de Génétique, Hôpital Necker-Enfants Malades, Paris, France.) 15657873,Molecular consequences of PHOX2B missense, frameshift and alanine expansion mutations leading to autonomic dysfunction.(Université Paris-Descartes, Faculté de Médecine; INSERM; AP-HP, Hôpital Necker-Enfants Malades, INSERM U-393, Paris, France.) 16249188,Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma.(Unité de Recherches sur les Handicaps Génétiques de l'Enfant, INSERM U-393, and Département de Génétique, Hôpital Necker-Enfants Malades, Paris, France.) 15024693
PHOX2B (8929) Ceccherini 2 The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells.(Laboratorio di Genetica Molecolare, Istituto Gerolamo Gaslini, 16148 Genova, Italy.) 16402914,An in vitro approach to test the possible role of candidate factors in the transcriptional regulation of the RET proto-oncogene.(Laboratorio di Genetica Molecolare, Istituto G. Gaslini, 16148 Genova, Italy.) 16127999
RUNX1 (861) Ito 3 Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome.(1Department of Pediatrics, Hirosaki University School of Medicine, Hirosaki, Japan.) 16628190,Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer.(Graduate School of Medical Science, Surgery and Regenerative Medicine, Surgery and Physiology of Digestive System, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kawaramachi-dori, Kyoto 602, Japan. pj.ca.m-upk.otok|arukakas#pj.ca.m-upk.otok|arukakas) 15386419,Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice.(Institute of Molecular and Cell Biology, Singapore.) 15856017
RUNX1 (861) Mann 2 The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor.(Center for Neurobiology and Behavior, Columbia University Medical School, New York, NY 10032, USA.) 15829516,Regulation of tissue inhibitor of metalloproteinase 1 gene transcription by RUNX1 and RUNX2.(Liver Group, Division of Infection, Inflammation, and Repair, University of Southampton Medical School, Southampton General Hospital, Southampton SO16 6YD, United Kingdom.) 15051730
RUNX1 (861) Hirai 2 AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.(Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, USA.) 14752096,AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis.(Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.) 14966519
RUNX1 (861) Pedersen-Bjergaard 2 Amplification or duplication of chromosome band 21q22 with multiple copies of the AML1 gene and mutation of the TP53 gene in therapy-related MDS and AML.(Department of Clinical Genetics, Section of Hematology/Oncology, The Juliane Marie Center, Rigshospitalet, Copenhagen, Denmark. kd.hr|akm#kd.hr|akm) 15618958,Mutations of AML1 are common in therapy-related myelodysplasia following therapy with alkylating agents and are significantly associated with deletion or loss of chromosome arm 7q and with subsequent leukemic transformation.(Department of Clinical Genetics, The Chromosome Laboratory, Section of Hematology/Oncology 4052, Juliane Marie Center, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ã, Denmark. kd.hr|sebed#kd.hr|sebed) 15142876
NR0B2 (8431) Choi 3 Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD.(Hormone Research Center, School of Biological Resources and Technology, Chonnam National University, Kwangju 500-757, Republic of Korea.) 14752053,Differential regulation of human and mouse orphan nuclear receptor small heterodimer partner promoter by sterol regulatory element binding protein-1.(Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Kwangju 500-757, Republic of Korea.) 15123650,Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding.(Hormone Research Center, Chonnam National University, Gwangju 500-757, Korea.) 15358835
PAX8 (7849) Zannini 3 Functional inactivation of the transcription factor Pax8 through oligomerization chain reaction.(Istituto di Endocrinologia ed Oncologia Sperimentale-Consiglio Nazionale delie Ricerche and Dipartimento di Biologia e Patologia Cellulare e Molecolare, Italy.) 16613988,WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8.(Istituto di Endocrinologia ed Oncologia Sperimentale-CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita' di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy.) 14531730,TAZ interacts with TTF-1 and regulates expression of surfactant protein-C.(Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.) 14970209
PAX8 (7849) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
VDR (7421) Weigel 3 Androgen receptor signaling and vitamin D receptor action in prostate cancer cells.(Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas77030, USA.) 15754350,Vitamin D receptor agonists induce prostatic acid phosphatase to reduce cell growth and HER-2 signaling in LNCaP-derived human prostate cancer cells.(Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.) 16076555,The functional consequences of cross-talk between the vitamin D receptor and ERK signaling pathways are cell-specific.(Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.) 15331595
VDR (7421) Garabédian 2 Vitamin D-resistant rickets and type 1 diabetes in a child with compound heterozygous mutations of the vitamin D receptor (L263R and R391S): dissociated responses of the CYP-24 and rel-B promoters to 1,25-dihydroxyvitamin D3.(INSERM Unité 561, Hôpital St Vincent de Paul, Paris, France. rf.mresni.5sirap|neyugn-iaht#rf.mresni.5sirap|neyugn-iaht) 16753019,The rapid effects of 1,25-dihydroxyvitamin D3 require the vitamin D receptor and influence 24-hydroxylase activity: studies in human skin fibroblasts bearing vitamin D receptor mutations.(CNRS UPR 1524/UMR 8104, Hôpital St Vincent de Paul, 75014 Paris, France. rf.oodanaw|pvs.srnc#rf.oodanaw|pvs.srnc) 14665637
VDR (7421) Todd 2 Associations of patella lead with polymorphisms in the vitamin D receptor, delta-aminolevulinic acid dehydratase and endothelial nitric oxide synthase genes.(Departments of Environmental Health Sciences, Johns Hopkins School of Medicine and Bloomberg School of Public Health, Baltimore, Maryland, USA.) 15213514,Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes.(Juvenile Diabetes Research Foundation/Wellcome Trust DiabetesInflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, WT/MRC building, Addenbrooke's Hospital, Cambridge, CB2 2XY, UK. ku.ca.mac.rmic|vestnejen.yegres#ku.ca.mac.rmic|vestnejen.yegres) 15448105
USF1 (7391) Peltonen 3 Risk alleles of USF1 gene predict cardiovascular disease of women in two prospective studies.(Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland.) 16699592,USF1 and dyslipidemias: converging evidence for a functional intronic variant.(Department of Molecular Medicine, National Public Health Institute, Finland.) 16076849,Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).(Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California 90095-7088, USA. ude.alcu.tendem|atnakujapp#ude.alcu.tendem|atnakujapp) 14991056
USF1 (7391) Kaetzel 2 Down-regulation of the polymeric immunoglobulin receptor in non-small cell lung carcinoma: correlation with dysregulated expression of the transcription factors USF and AP2.(Department of Pathology and Laboratory Medicine, University of Kentucky College of Medicine, Lexington, KY 40536, USA.) 15864740,Upstream stimulatory factor but not c-Myc enhances transcription of the human polymeric immunoglobulin receptor gene.(Department of Pathology & Laboratory Medicine, University of Kentucky, Lexington, KY 40536, USA.) 14644095
USF1 (7391) 2
USF1 (7391) Galibert 2 [USF as a key regulatory element of gene expression](CNRS UMR 6061, Laboratoire de génétique et développement, Faculté de Médecine, Université de Rennes 1, France.) 16386222,UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1).(CNRS UMR 6061 Laboratoire de Génétique et Développement, Faculté de Médecine, Université de Rennes-1, 2 Avenue du Pr. Léon Bernard, 35043 Rennes, France.) 15358786
UBTF (7343) Zomerdijk 3 RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor.(Division of Gene Regulation and Expression, School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom.) 16809778,UBF activates RNA polymerase I transcription by stimulating promoter escape.(Division of Gene Regulation and Expression, School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee, UK.) 16858408,TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter.(Division of Gene Regulation and Expression, School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Scotland, UK.) 15970593
UBTF (7343) Shi 2 Compact molten globule-like state of hUBF HMG Box1 at extremely low pH.(School of Life Science, University of Science and Technology of China, People's Republic of China.) 15752694,Structural and dynamic characterization of the acid-unfolded state of hUBF HMG box 1 provides clues for the early events in protein folding.(Hefei National Laboratory for Physical Sciences at Microscale, School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China.) 15924431
KLF5 (688) Nagai 3 The deacetylase HDAC1 negatively regulates the cardiovascular transcription factor Krüppel-like factor 5 through direct interaction.(Department of Cardiovascular Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.) 15668237,Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.(Department of Cardiovascular Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan.) 16054042,Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB.(Department of Cardiovascular Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.) 14573617
KLF5 (688) Dong 2 Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells.(Department of Oncology and Hematology, Winship Cancer Institute, Emory University School of Medicine, 1365-C Clifton Road, Atlanta, GA, USA.) 15735697,Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells.(Winship Cancer Institute and Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.) 16223724
KLF5 (688) Yang 2 Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras.(Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA.) 15077182,All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Kruppel-like factor 5.(Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 201 Whitehead Research Building, 615 Michael Street, Atlanta, GA, USA.) 15581624
STAT3 (6774) Kitagawa 3 Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2.(Department of Physiology, Osaka City University Graduate School of Medicine, Japan.) 15845643,Selective activation of STAT3 in human monocytes stimulated by G-CSF: implication in inhibition of LPS-induced TNF-alpha production.(Department of Physiology, Osaka City University Medical School, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.) 14736711,Proteolytic conversion of STAT3alpha to STAT3gamma in human neutrophils: role of granule-derived serine proteases.(Department of Physiology, Osaka City University Medical School, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.) 15145953
STAT3 (6774) Chin 3 Stat3 cleavage by caspases: impact on full-length Stat3 expression, fragment formation, and transcriptional activity.(Department of Medicine, Division of Medical Oncology, Brown University and Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA. gro.napsefil|ikswonradj#gro.napsefil|ikswonradj) 16636048,Stat3 dimerization regulated by reversible acetylation of a single lysine residue.(Department of Surgery, Brown University Medical School-Rhode Island Hospital, Providence, RI 02903, USA.) 15653507,Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells.(Department of Surgery Science, Brown University School of Medicine/Rhode Island Hospital, 593 Eddy St., Providence, RI 02903, USA.) 15485908
STAT3 (6774) Lin 3 Evaluation of potential Stat3-regulated genes in human breast cancer.(Center for Childhood Cancer, Columbus Children's Research Institute, The Ohio State University, Columbus, OH 43205, USA.) 16081048,Stat3 modulates heat shock 27kDa protein expression in breast epithelial cells.(Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan Comprehensive Cancer Center, Cellular and Molecular Biology Graduate Program, Ann Arbor, MI 48109-0936, USA.) 14715258,Stat3 upregulates MEK5 expression in human breast cancer cells.(Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cellular and Molecular Biology Graduate Program, University of Michigan Comprehensive Cancer Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109-0936, USA.) 15378007
STAT3 (6774) Luo 2 Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation.(Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.) 15649887,A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells.(Department of Experimental Therapeutics, Biochemistry and Molecular Biology, Immunology, and Molecular Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.) 16061651
STAT3 (6774) Wang 2 RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth.(Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029-6574, USA.) 16382134,Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.(Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, GA 30912, USA.) 16236267
STAT3 (6774) Matsuda 2 Physical and functional interactions between Daxx and STAT3.(Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.) 16331268,Nuclear retention of STAT3 through the coiled-coil domain regulates its activity.(Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-Ku Kita 12 Nishi 6, Sapporo 060-0812, Japan.) 16140268
STAT3 (6774) Wasik 2 STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes.(Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 7.103 Founders, Philadelphia, 19104, USA. ude.nnepu.dem.liam|2naiq#ude.nnepu.dem.liam|2naiq) 16861352,STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.(Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.) 15870198
STAT3 (6774) Wong 2 Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: a mechanism requiring PTX-insensitive G proteins, ERK and JNK.(Department of Biochemistry, Molecular Neuroscience Center, and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.) 15979846,Regulation of STAT3 by mu-opioid receptors in human neuroblastoma SH-SY5Y cells.(Department of Biochemistry, the Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.) 15194868
STAT3 (6774) Shaw 2 Bacterial N-acylhomoserine lactone-induced apoptosis in breast carcinoma cells correlated with down-modulation of STAT3.(School of Biomedical Sciences, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.) 15064716,A STAT3 dimer formed by inter-chain disulphide bridging during oxidative stress.(School of Biomedical Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK.) 15336564
STAT3 (6774) Friedrich 2 Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth.(Institute of Biochemistry I, Friedrich-Schiller University Jena Medical School, Jena, Germany.) 16036105,Leukemia inhibitory factor triggers activation of signal transducer and activator of transcription 3, proliferation, invasiveness, and altered protease expression in choriocarcinoma cells.(Department of Obstetrics, Friedrich-Schiller-University Jena, Bachstrasse 18, 07740 Jena, Germany.) 16125646
STAT1 (6772) Chen 3 Structural bases of unphosphorylated STAT1 association and receptor binding.(Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center , The University of Texas, Houston, Texas 77030, USA.) 15780933,Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK.(Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis, Chinese Ministry of Education, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine (formerly Shanghai Second Medical University), Shanghai 200025, China.) 16260419,Crystallization and X-ray crystallographic analysis of human STAT1.(Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Box 117, Houston, TX 77030, USA.) 16511123
STAT1 (6772) Vinkemeier 3 Nuclear export determines the cytokine sensitivity of STAT transcription factors.(Abteilung Zelluläre Signalverarbeitung, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Freie Universität Berlin, 13125 Berlin, Germany.) 16195225,A single residue modulates tyrosine dephosphorylation, oligomerization, and nuclear accumulation of stat transcription factors.(Abteilung Zelluläre Signalverarbeitung, Forschungsinstitut für Molekulare Pharmakologie, Freie Universität Berlin, 13125 Berlin, Germany.) 15010467,Nucleocytoplasmic shuttling by nucleoporins Nup153 and Nup214 and CRM1-dependent nuclear export control the subcellular distribution of latent Stat1.(Abteilung Zellulare Signalverarbeitung, Leibniz-Forschungsinstitut fur Molekulare Pharmakologie, Robert-Rossle-Str. 10, 13125 Berlin, Germany.) 15210729
STAT1 (6772) Ivashkiv 3 Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation.(Arthritis and Tissue Degeneration Program, Department of Medicine, Hospital for Special Surgery, New York, New York 10021, USA.) 16571725,IFN-gamma-primed macrophages exhibit increased CCR2-dependent migration and altered IFN-gamma responses mediated by Stat1.(Arthritis and Tissue Degeneration Program, Department of Medicine, Hospital for Special Surgery, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA.) 16148108,Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors.(Arthritis and Tissue Degeneration Program, Department of Medicine, Hospital for Special Surgery, New York, New York 10021, USA.) 15467722
STAT1 (6772) Chung 2 Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain.(Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.) 16940534,Hepatitis C virus expression suppresses interferon signaling by degrading STAT1.(Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.) 15825084
STAT1 (6772) Fagard 2 Latent membrane protein 1 regulates STAT1 through NF-kappaB-dependent interferon secretion in Epstein-Barr virus-immortalized B cells.(UPRES EA 34306, Service de Biochimie, AP-HP, Hôpital Avicenne, 125 Rue de Stalingrad, 93009 Bobigny Cedex, France.) 15795279,Differential roles of STAT1alpha and STAT1beta in fludarabine-induced cell cycle arrest and apoptosis in human B cells.(EA 3406 Université Paris 13, Service de Biochimie, Hôpital Avicenne, 125 route de Stalingrad, 93009 Bobigny Cedex, France.) 15217838
STAT1 (6772) Stephanou 2 Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury.(Department of Medical Molecular Biology, The Institute of Child Health, University College London, 30 Guilford St., London, WC1N 1EH, UK.) 16935931,STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage.(Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK.) 15784679
STAT1 (6772) Frank 2 Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis.(Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.) 16585190,Oral fludarabine has significant activity in patients with previously untreated chronic lymphocytic leukemia, and leads to increased STAT1 levels in vivo.(James P. Wilmot Cancer Center, University of Rochester, 601 Elmwood Avenue, Box 704, Rochester, NY 14642, USA. ude.retsehcor.cmru|grebdeirf_nahtanoj#ude.retsehcor.cmru|grebdeirf_nahtanoj) 14654078
SOX10 (6663) Wegner 3 Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas.(Department of Pathology, Yale University School of Medicine, New Haven, CT 65210, USA. ude.elay|hkynnaB.ieugreS#ude.elay|hkynnaB.ieugreS) 16205963,The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.(Institut für Biochemie, Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany.) 16582099,The high-mobility group transcription factor Sox10 interacts with the N-myc-interacting protein Nmi.(Institut für Biochemie, Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany.) 16214168
SOX10 (6663) Kato 2 A family-based and case-control association study of SOX10 in schizophrenia.(Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan. pj.nekir.niarb|otak#pj.nekir.niarb|otak) 16741945,DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia.(Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama 351-0198, Japan. pj.nekir.niarb|otomawizak#pj.nekir.niarb|otomawizak) 15930386
RB1 (5925) Chellappan 3 Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors.(Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.) 15735762,Direct binding of apoptosis signal-regulating kinase 1 to retinoblastoma protein: novel links between apoptotic signaling and cell cycle machinery.(Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.) 15210709,Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis.(Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Dr., Tampa, FL 33612, USA.) 15485920
RB1 (5925) Kitagawa 2 Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner.(Department of Biochemistry 1, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan.) 16343421,Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.(Department of Biochemistry 1, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.) 15577944
RB1 (5925) Koeffler 2 C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation.(Cedars-Sinai Medical Center, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, CA 90048, USA. gro.shsc|syreg#gro.shsc|syreg) 15674331,C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis.(Cedars-Sinai Medical Center, Davis Bldg 5066, 8700 Beverly Blvd, Los Angeles, CA 90048, USA. gro.shsc|syreg#gro.shsc|syreg) 12947005
RB1 (5925) Vogt 2 Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma.(Department of Dermatology, University of Regensburg, Regensburg, Germany. ed.grubsneger-inu.kinilk|hcseor.rednaxela#ed.grubsneger-inu.kinilk|hcseor.rednaxela) 15502804,Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas.(Department of Dermatology, University of Regensburg, Regensburg, Germany. ed.grubsneger-inu.kinilk|hcseor.rednaxela#ed.grubsneger-inu.kinilk|hcseor.rednaxela) 15803180
RB1 (5925) Hinds 2 Multiple functions of D-type cyclins can antagonize pRb-mediated suppression of proliferation.(Harvard Medical School, Department of Pathology, Boston, Massachusetts, USA.) 15684604,Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma.(Ian Potter Foundation Centre for Cancer Genomics and Predictive Medicine, and Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Center, Victoria, Melbourne, Australia. gro.camretep|samoht.divad#gro.camretep|samoht.divad) 15583032
RB1 (5925) Lee 2 Overexpression of RB1 transcript is significantly correlated with 13q14 allelic imbalance in colorectal carcinomas.(Department of Paediatrics, National University of Singapore, Singapore.) 16570290,Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation.(Division of Diabetes, Endocrinology & Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.) 14645241
RB1 (5925) Drouin 2 Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription.(Laboratoire de génétique moléculaire, Institut de recherches cliniques de Montréal (IRCM), Montréal, Québec H2W 1R7, Canada.) 15701640,Rb enhances p160/SRC coactivator-dependent activity of nuclear receptors and hormone responsiveness.(Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal, Quebec, Canada.) 15767262
RB1 (5925) Gallie 2 Distinct patterns of expression of the RB gene family in mouse and human retina.(The Division of Cancer Informatics, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, Canada.) 15939381,Retinoblastoma: revisiting the model prototype of inherited cancer.(Institut für Humangenetik, Hufelandstrasse 55, D-45122 Essen, Germany. ed.nesse-inu|nnamhol.rd#ed.nesse-inu|nnamhol.rd) 15264269
RB1 (5925) Robertson 2 Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase.(Department of Microbiology and the Tumor Virology Program, Abramson Comprehensive Cancer Center, University of Pennsylvania, 201E Johnson Pavilion, Philadelphia, PA 19104, USA.) 16352731,ORF73 of herpesvirus saimiri, a viral homolog of Kaposi's sarcoma-associated herpesvirus, modulates the two cellular tumor suppressor proteins p53 and pRb.(Department of Microbiology and Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 15367600
RB1 (5925) Longmore 2 Differences in stability of repressor complexes at promoters underlie distinct roles for Rb family members.(Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.) 14737116,Differential regulation of apoptotic genes by Rb in human versus mouse cells.(Department of Medicine, Washington University School of Medicine, 4940 Parkview Place, St Louis, MO 63110, USA.) 15048095
RARB (5915) Lotan 3 Hypermethylation of the retinoic acid receptor-beta(2) gene in head and neck carcinogenesis.(Departments of Thoracic/Head and Neck Medical Oncology,The University of Texas, MD Anderson Cancer Center, Houston, Texas 77345, USA.) 15014026,Retinoic acid receptor beta2 hypermethylation: implications for prostate cancer detection, prevention, and therapy.() 15217922,Regulation of RARbeta1 expression in head and neck cancer cells by cell density-dependent chromatin remodeling.(Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA. gro.nosrednadm|fessuoye#gro.nosrednadm|fessuoye) 15467435
RARB (5915) Yasui 2 DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage.(Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.) 16128742,DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation.(Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Kasumi, Hiroshima, Japan.) 16134180
POU4F1 (5457) Latchman 3 Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a.(Medical Molecular Biology Unit, Institute of Child Health, University College London, and Department of Women's and Children's Health, The Whittington Hospital, London, UK.) 16247485,Brn-3a neuronal transcription factor functional expression in human prostate cancer.(Medical Molecular Biology Unit, Institute of Child Health, University College London, London, UK. ku.ca.lcu.hci|ssid.j#ku.ca.lcu.hci|ssid.j) 16276351,The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1.(Medical Molecular Biology Unit, Institute of Child Health, UCL, 30 Guilford Street, London WC1N 1EH, UK. ku.ca.lcu.hci|enyocsag.d#ku.ca.lcu.hci|enyocsag.d) 15021903
PAX6 (5080) Sundaresan 3 PAX6 missense mutations associated in patients with optic nerve malformation.(Department of Genetics, Aravind Medical Research Foundation, Madurai, India.) 16604056,Identification of novel mutant PAX6 alleles in Indian cases of familial aniridia.(Department of Genetics, Aravind Medical Research Foundation, Madurai, India. moc.liamffider|najarihteen#moc.liamffider|najarihteen) 16803629,PAX6 gene variations associated with aniridia in south India.(Department of Genetics, Aravind Medical Research Foundation, Madurai, India. gro.dnivara|najarihteen#gro.dnivara|najarihteen) 15086958
PAX6 (5080) Hanson 2 PAX6 mutations: genotype-phenotype correlations.(Molecular Medicine Centre, Western General Hospital, School of Molecular and Clinical Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK. ku.ca.de.sms|ikaluozt.i#ku.ca.de.sms|ikaluozt.i) 15918896,A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11.(University of Edinburgh, School of Molecular and Clinical Medicine, Medical Sciences (Medical Genetics), Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU. ku.ca.de|repooc.t.nomis#ku.ca.de|repooc.t.nomis) 16098226
PAX6 (5080) Nakafuku 2 The Pax6 isoform bearing an alternative spliced exon promotes the development of the neural retinal structure.(Department of Ophthalmology, National Center for Child Health and Developent, Tokyo, Japan. pj.og.dhccn|n-amuza#pj.og.dhccn|n-amuza) 15677484,Transdifferentiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor.(Department of Ophthalmology, National Center for Child Health and Development, Tokyo 157-8535, Japan. pj.og.dhccn|n-amuza#pj.og.dhccn|n-amuza) 15757974
NRL (4901) Swaroop 3 Retinoic acid regulates the expression of photoreceptor transcription factor NRL.(Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan 48105, USA, and Translational Research Center, Kyoto University Hospital, Japan.) 16854989,The minimal transactivation domain of the basic motif-leucine zipper transcription factor NRL interacts with TATA-binding protein.(Department of Ophthalmology, WK Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105, USA.) 15328344,Mutation analysis of NR2E3 and NRL genes in Enhanced S Cone Syndrome.(MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom. ku.crm.ugh|thgirw.nala#ku.crm.ugh|thgirw.nala) 15459973
MYB (4602) Ishii 3 Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK.(Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, Tsukuba, Ibaraki 305-0074, Japan.) 15082531,Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation.(Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan.) 15308626,p53 suppresses c-Myb-induced trans-activation and transformation by recruiting the corepressor mSin3A.(Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan.) 15509555
MYB (4602) Thein 2 cMYB is involved in the regulation of fetal hemoglobin production in adults.(Department of Haematological Medicine, King's College London School of Medicine at King's College Hospital, Denmark Hill Campus, London SE5 9PJ, United Kingdom.) 16861354,Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin expression in adults.(Department of Haematological Medicine, GKT School of Medicine, London, SE5 9PJ, UK. ku.ca.xo.hcysp|esolc.semaj#ku.ca.xo.hcysp|esolc.semaj) 15169551
MAZ (4150) Ray 3 Inflammation-responsive transcription factor SAF-1 activity is linked to the development of amyloid A amyloidosis.(Department of Veterinary Pathobiology, University of Missouri, 126A Connaway Hall, Columbia, MO 65211, USA. ude.iruossim|layar#ude.iruossim|layar) 16888022,Overexpression of serum amyloid A-activating factor 1 inhibits cell proliferation by the induction of cyclin-dependent protein kinase inhibitor p21WAF-1/Cip-1/Sdi-1 expression.(Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA. ude.iruossim|layar#ude.iruossim|layar) 15067082,Induction of the MMP-14 gene in macrophages of the atherosclerotic plaque: role of SAF-1 in the induction process.(Department of Veterinary Pathobiology, University of Missouri, 126A Connaway Hall, 1600 E Rollins Rd, Columbia, MO 65211, USA. ude.iruossim|layar#ude.iruossim|layar) 15528467
ARNT (405) Whitelaw 3 Novel DNA binding by a basic helix-loop-helix protein. The role of the dioxin receptor PAS domain.(School of Molecular and Biomedical Science (Biochemistry), University of Adelaide, South Australia, Australia. ua.ude.edialeda|htimsnampahc.enna#ua.ude.edialeda|htimsnampahc.enna) 16520375,Phosphorylation inhibits DNA-binding of alternatively spliced aryl hydrocarbon receptor nuclear translocator.(School of Molecular and Biomedical Science (Biochemistry), Centre for the Molecular Genetics of Development, University of Adelaide, SA 5005, Australia. ua.ude.usc|yelwekr#ua.ude.usc|yelwekr) 16129408,Contribution of the Per/Arnt/Sim (PAS) domains to DNA binding by the basic helix-loop-helix PAS transcriptional regulators.(School of Molecular and Biomedical Science (Biochemistry), University of Adelaide, South Australia, Australia. ua.ude.edialeda|htimsnampahc.enna#ua.ude.edialeda|htimsnampahc.enna) 14638687
MAFA (389692) Stein 3 FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site.(Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medical Center,723 Light Hall, Nashville, TN 37232, USA.) 16847327,The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription.(Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.) 15665000,The MafA transcription factor appears to be responsible for tissue-specific expression of insulin.(Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 723 Light Hall, Nashville, TN 37232, USA.) 14973194
JUN (3725) Chen 3 Japanese encephalitis virus NS2B-NS3 protease binding to phage-displayed human brain proteins with the domain of trypsin inhibitor and basic region leucine zipper.(Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan, Taiwan, ROC. wt.ude.umc.liam|nilwc#wt.ude.umc.liam|nilwc) 16289409,Estrogen receptor inhibits c-Jun-dependent stress-induced cell death by binding and modifying c-Jun activity in human breast cancer cells.(Department of Radiation Oncology and Division of Biochemistry of the Department of Cell Biology, Neurobiology, and Anatomy, Loyola University of Chicago, Maywood, Illinois 05163.) 14638681,A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.(Gene Transfer Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Largo R. Benzi 10, 16132 Genoa, Italy. moc.oohay|izrehgr#moc.oohay|izrehgr) 15175153
JUN (3725) He 2 Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis.(Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese Human Genome Center of Beijing, Beijing, PR China.) 15706351,Direct association of hepatopoietin with thioredoxin constitutes a redox signal transduction in activation of AP-1/NF-kappaB.(Laboratory of Systems Biology, Beijing Institute of Radiation Medicine, Chinese Human Genome Center at Beijing.) 15894171
JUN (3725) Liu 2 A novel human KRAB-containing zinc-finger gene ZNF446 inhibits transcriptional activities of SRE and AP-1.(The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China. ude.cshmat.tbi|uilm#ude.cshmat.tbi|uilm) 15936718,TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1.(The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha 410081, Hunan, People's Republic of China.) 15351693
JUN (3725) Wang 2 Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling.(Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.) 16023595,Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.(Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, GA 30912, USA.) 16236267
IRF3 (3661) Shu 3 VISA is an adapter protein required for virus-triggered IFN-beta signaling.(Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA.) 16153868,Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.(Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA. gro.cjn|huhs#gro.cjn|huhs) 14739303,PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis.(National Jewish Medical and Research Center, 1400 Jackson Street, k516c, Denver, CO 80206, USA.) 15251447
IRF3 (3661) Gale 3 West Nile virus evades activation of interferon regulatory factor 3 through RIG-I-dependent and -independent pathways without antagonizing host defense signaling.(Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, USA.) 16501100,Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection.(Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.) 16585524,The host response to West Nile Virus infection limits viral spread through the activation of the interferon regulatory factor 3 pathway.(Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9048, USA.) 15220448
IRF3 (3661) Mossman 2 The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes.(Lady Davis Research Institute, Montreal H3T 1E2, Canada.) 14747533,Innate cellular response to virus particle entry requires IRF3 but not virus replication.(Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5.) 14747536
IRF3 (3661) Sen 2 Analysis of genes induced by Sendai virus infection of mutant cell lines reveals essential roles of interferon regulatory factor 3, NF-kappaB, and interferon but not toll-like receptor 3.(Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195, USA.) 15767394,Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling.(Department of Molecular Biology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.) 15502848
IRF1 (3659) Watanabe 3 IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome.(Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Japan.) 15907481,Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells.(Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.) 15226432,Regulation of hepatitis C virus replication by interferon regulatory factor 1.(Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.) 15331704
IRF1 (3659) Ross 2 Retinoic acid exerts dual regulatory actions on the expression and nuclear localization of interferon regulatory factor-1.(Department of Nutritional Sciences, 126-S Henderson Building, University Park, PA 16802, USA.) 16636311,Physiological and receptor-selective retinoids modulate interferon gamma signaling by increasing the expression, nuclear localization, and functional activity of interferon regulatory factor-1.(Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.) 16085646
IRF1 (3659) Ball 2 A novel repressor domain is required for maximal growth inhibition by the IRF-1 tumor suppressor.(Cancer Research UK (CRUK) Interferon and Cell Signalling Group, Cell Signalling Unit, The University of Edinburgh Cancer Research Centre, Edinburgh EH4 2XR, United Kingdom.) 16679314,Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53.(CRUK Interferon and Cell Signalling Group, Cell Signalling Unit, Cancer Research Centre, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, United Kingdom.) 15509808
IRF1 (3659) Clarke 2 Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis.(Lombardi Comprehensive Cancer Center and Department of Oncology, Georgetown University School of Medicine, 3970 Reservoir Road NW, Washington, DC 20057, USA.) 15878912,interferon regulatory factor-1 mediates the proapoptotic but not cell cycle arrest effects of the steroidal antiestrogen ICI 182,780 (faslodex, fulvestrant).(Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, District of Columbia 20007, USA.) 15173018
IRF1 (3659) Lee 2 Alternative splicing variants of IRF-1 lacking exons 7, 8, and 9 in cervical cancer.(Molecular Therapy Research Center, Sungkyunkwan University, Seoul 135-710, Republic of Korea.) 16857162,IFN-gamma/IRF-1-induced p27kip1 down-regulates telomerase activity and human telomerase reverse transcriptase expression in human cervical cancer.(Molecular Therapy Research Center, School of Medicine, Sungkyunkwan University, Samsung Medical Center Annex 8F, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Korea.) 15710386
AIRE (326) Peterson 3 Ets transcription factors regulate AIRE gene promoter.(Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland. if.atu|umsatl#if.atu|umsatl) 16890195,Cooperative activation of transcription by autoimmune regulator AIRE and CBP.(Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland.) 15964547,Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage.(Department of Pathology, Institute of Medical Technology, Tampere University Hospital, University of Tampere, Finnmedi-1, Biokatu 6, Tampere 33014, Finland. if.tut.sc|nnallis#if.tut.sc|nnallis) 15482854
AIRE (326) Matsumoto 2 AIRE functions as an E3 ubiquitin ligase.(Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.) 14734522,Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner.(Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima, Tokushima 770-8503, Japan.) 15150263
NR4A1 (3164) Youn 3 A novel function of Nur77: physical and functional association with protein kinase C.(Department of Biochemistry and Molecular Biology, Cancer Research Institute, Interdisciplinary Program in Genetic Engineering, Seoul National University College of Medicine, 28 Yongon-dong, Chongro-gu, Seoul 110-799, Republic of Korea.) 16904076,Menin represses JunD transcriptional activity in protein kinase C theta-mediated Nur77 expression.(Department of Biochemistry and Molecular Biology, Cancer Research Institute, Seoul National University, College of Medicine, 28 Yongon-dong, Chongro-gu, Seoul 110-799, Korea.) 16264271,Nur77 activated by hypoxia-inducible factor-1alpha overproduces proopiomelanocortin in von Hippel-Lindau-mutated renal cell carcinoma.(Department of Biochemistry and Molecular Biology, Cancer Research Institute, Seoul, South Korea.) 14729605
NR4A1 (3164) Zhang 3 Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt.(Burnham Institute for Medical Research, Cancer Center, La Jolla, CA 92037, USA.) 16434970,Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3.(The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.) 14980220,Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected by modulating its nuclear export and mitochondrial targeting.](The Burnham Institute, Cancer Center, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, USA.) 15509776
NR4A1 (3164) de Vries 2
NR4A1 (3164) Denis 2 Inhibition of apoptosis by Nur77 through NF-kappaB activity modulation.(1INRS-Institut Armand-Frappier, Laval, QC, Canada.) 16082387,Nur77 forms novel nuclear structures upon DNA damage that cause transcriptional arrest.(INRS-Institut Armand-Frappier, 531 Boulevard des Prairies, Laval (QC), Canada H7V 1B7.) 16480977
NR4A1 (3164) Lee 2 Negative cross-talk between Nur77 and small heterodimer partner and its role in apoptotic cell death of hepatoma cells.(College of Pharmacy, Seoul National University, San 56-1 Sillim, Kwanak, Seoul 151-742, Korea.) 15625237,Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha.(Department of Bioscience and Biotechnology, Sejong University, Seoul 143-747, Korea.) 15385570
NRG1 (3084) He 3 Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia.(Bio-X Center, Shanghai Jiao Tong University, Shanghai, China.) 16687441,Polymorphisms within 5' end of the Neuregulin 1 gene are genetically associated with schizophrenia in the Chinese population.() 14647391,A case control and family based association study of the neuregulin1 gene and schizophrenia.() 14729827
NRG1 (3084) Weinberger 2 Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease.(Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom. ku.ca.xo.hcysp|wal.adnama#ku.ca.xo.hcysp|wal.adnama) 16618933,Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia.(Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, MD 20892, USA.) 14569272
GLI1 (2735) Xie 3 Hedgehog signaling is activated in subsets of esophageal cancers.(Institute of Developmental Biology, School of Life Sciences, Shandong University, Jinan, China.) 16003737,Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal.(Sealy Center for Cancer Cell Biology and Department of Pharmacology, University of Texas Medical Branch, Galveston, Texas 7555-1048, USA.) 16293631,Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas.(Institute of Developmental Biology, School of Life Sciences, Shandong University, Jinan, PR China.) 15905200
GLI1 (2735) Panagopoulos 2 Activation of the GLI oncogene through fusion with the beta-actin gene (ACTB) in a group of distinctive pericytic neoplasms: pericytoma with t(7;12).(Department of Clinical Genetics, University Hospital, Lund, Sweden. es.ul.negnilk|nelhad.anna#es.ul.negnilk|nelhad.anna) 15111311,Molecular genetic characterization of the genomic ACTB-GLI fusion in pericytoma with t(7;12).(Department of Clinical Genetics, University Hospital, SE-221 85 Lund, Sweden. es.ul.negnilk|nelhad.anna#es.ul.negnilk|nelhad.anna) 15555571
GATA1 (2623) Vyas 3 GATA1 mutation analysis demonstrates two distinct primary leukemias in a child with down syndrome; implications for leukemogenesis.() 16012335,Natural history of GATA1 mutations in Down syndrome.(Department of Hematology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK.) 14656875,Differences in the chromatin structure and cis-element organization of the human and mouse GATA1 loci: implications for cis-element identification.(Department of Haematology, Medical Research Council Molecular Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DU, United Kingdom.) 15265794
GATA1 (2623) Mackay 2 Molecular analysis of the interaction between the hematopoietic master transcription factors GATA-1 and PU.1.(School of Molecular and Microbial Biosciences, G08, University of Sydney, New South Wales 2006, Australia.) 16861236,Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction.(School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia.) 15644435
GATA1 (2623) Taub 2 Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia.(Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute of Environmental Sciences, Wayne State University, Detroit, MI 48201, USA.) 16249385,The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines.(Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, Michigan, USA.) 14744791
GATA1 (2623) Kanakura 2 Notch signals inhibit the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through the induction of HES1.(Department of Hematology and Oncology, Osaka University Graduate School of Medicine, 2-2, Yamada-oka, Suita, Osaka 565-0871, Japan.) 15563463,GATA transcription factors inhibit cytokine-dependent growth and survival of a hematopoietic cell line through the inhibition of STAT3 activity.(Department of Hematology/Oncology, Osaka University Graduate School of Medicine, 2-2, Yamada-oka, Suita, Osaka 565-0871, Japan.) 15673499
FOS (2353) Wang 3 Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling.(Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.) 16023595,Effect of c-fos antisense probe on prostaglandin E2-induced upregulation of vascular endothelial growth factor mRNA in human liver cancer cells.(Comprehensive Diagnostic and Therapeutic Center, Xijing Hospital, the Fourth Military Medical University, Xi'an 710033, Shaanxi Province, China. nc.moc.oohay|33liqgnoy#nc.moc.oohay|33liqgnoy) 16038047,Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.(Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, GA 30912, USA.) 16236267
FOXO3A (2309) Lam 3 The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells.(Cancer Research-United Kingdom Laboratories, Department of Oncology, MRC Cyclotron Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom.) 16809346,Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.(Cancer Research-UK labs, Department of Cancer Medicine, MRC Cyclotron Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.) 15688014,FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism.(Cancer Research-UK Laboratories, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom.) 15509806
FOXO3A (2309) Chrousos 2 HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected patients.(Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, NIH, 10 Center Dr. MSC 1109, Building 10, Clinical Research Center, Room 1-3140, Bethesda, MD 20892-1109, USA. vog.hin.liam|tonik#vog.hin.liam|tonik) 15616007,Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?(Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1583, USA. vog.hin.liam|tonik#vog.hin.liam|tonik) 15265780
ETS1 (2113) Sekine 3 Expression of Ets-1 proto-oncoprotein in gastrointestinal stromal tumors, leiomyomas and schwannomas.(Department of Molecular Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. pj.ca.u-ikasagan.ten|n-ihsot#pj.ca.u-ikasagan.ten|n-ihsot) 16586544,Expression of the ets-1 proto-oncogene in human breast carcinoma: differential expression with histological grading and growth pattern.(Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan.) 15578430,Overexpression of Ets-1 proto-oncogene in latent and clinical prostatic carcinomas.(Tissue and Histopathology Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.) 15693893
ETS1 (2113) Bosserhoff 2 Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1.(Institute of Pathology, University of Regensburg, 93053 Regensburg, Germany.) 16684505,The Ets-1 transcription factor is involved in the development and invasion of malignant melanoma.(Institute of Pathology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93042, Regensburg, Germany.) 14704859
ETS1 (2113) Trojanowska 2 Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.(Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.) 16278291,Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program.(Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.) 16829517
ETS1 (2113) von Deimling 2
ETS1 (2113) Watson 2 SP100 inhibits ETS1 activity in primary endothelial cells.(Department of Pathology and Laboratory Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.) 15592518,SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion.(Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.) 15247905
ETS1 (2113) Wernert 2 Expression pattern of matrix metalloproteinase and TIMP genes in fibroblasts derived from Ets-1 knock-out mice compared to wild-type mouse fibroblasts.(Institute of Pathology, University of Bonn, 53011 Bonn, Germany.) 16786167,Ets-1 expression promotes epithelial cell transformation by inducing migration, invasion and anchorage-independent growth.(Institute of Pathology, University of Bonn, PO Box 2120, 53011 Bonn, Germany.) 15940256
ESR2 (2100) Gustafsson 3 Estrogen receptor (ER) beta modulates ERalpha-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen-responsive promoters.(Department of Biosciences at Novum, Karolinska Institutet, Huddinge 14157, Sweden. es.ik.icsoib|swehttam.nosaj#es.ik.icsoib|swehttam.nosaj) 16293641,Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D.(Department of Biosciences, Karolinska Institutet, Novum, S-14157 Huddinge, Sweden.) 14745018,Identification of tamoxifen-induced coregulator interaction surfaces within the ligand-binding domain of estrogen receptors.(Department of Biosciences at Novum, Karolinska Institutet, S-14157 Huddinge, Sweden.) 15060164
ESR2 (2100) Muyan 2 Binding of estrogen receptor beta to estrogen response element in situ is independent of estradiol and impaired by its amino terminus.(University of Rochester School of Medicine and Dentistry, Department of Biochemistry and Biophysics, Rochester, New York 14642, USA.) 15976006,Single-chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways.(Department of Biochemistry and Biophysics, University of Rochester School of Medicine, 601 Elmwood Ave., Rochester, NY 14642, USA.) 15314175
ESR2 (2100) Levin 2 Nature of functional estrogen receptors at the plasma membrane.(Division of Endocrinology, Veterans Affairs Medical Center, Long Beach, CA 90822, USA.) 16645038,Plasma membrane estrogen receptors exist and functions as dimers.(Long Beach Veterans Affairs Medical Center/University of California-Irvine, 5901 East 7th Street, Long Beach, California 90822, USA.) 15231873
ESR2 (2100) Andò 2 Estrogen receptor (ER)alpha and ER beta are both expressed in human ejaculated spermatozoa: evidence of their direct interaction with phosphatidylinositol-3-OH kinase/Akt pathway.(Centro Sanitario, University of Calabria 87030 Arcavacata di Rende, Cosenza, Italy. ti.orebil|vasiuqa#ti.orebil|vasiuqa) 15001646,Oestrogen receptor beta is required for androgen-stimulated proliferation of LNCaP prostate cancer cells.(Department of Pharmaco-Biology, University of Calabria, 87036 Rende (CS), Italy.) 15171712
ESR2 (2100) Ho 2 Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling.(Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, College of Medicine, University of Cincinnati, OH 45267, USA.) 16938840,Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis.(Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01605-2324, USA.) 15161636
ESR2 (2100) Yager 2 Mitochondrial localization of ERalpha and ERbeta in human MCF7 cells.(Division of Toxicological Sciences, Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.) 14736707,Binding of MCF-7 cell mitochondrial proteins and recombinant human estrogen receptors alpha and beta to human mitochondrial DNA estrogen response elements.(Department of Environmental Health Sciences, Division of Toxicological Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe St. Baltimore, Maryland 21205-2179, USA. ude.cccf|nehc.gnaiqnij#ude.cccf|nehc.gnaiqnij) 15368362
ESR2 (2100) Kang 2 Tamoxifen-resistant breast cancers show less frequent methylation of the estrogen receptor beta but not the estrogen receptor alpha gene.(Department of Biology, Dongguk University, 100-715 Seoul, Korea.) 15536519,CpG methylation of the ERalpha and ERbeta genes in breast cancer.(Department of Biology, Dongguk University, Seoul 100-715, Korea.) 15254780
ESR2 (2100) Marino 2 Survival versus apoptotic 17beta-estradiol effect: role of ER alpha and ER beta activated non-genomic signaling.(Department of Biology, University Roma Tre, Rome, Italy.) 15389627,Mechanisms of naringenin-induced apoptotic cascade in cancer cells: involvement of estrogen receptor alpha and beta signalling.(Department of Biology, University Roma Tre, Viale G. Marconi, 446, I-00146 Rome, Italy.) 15545229
ESR2 (2100) Zhu 2 Potentiation of estrogen receptor transcriptional activity by breast cancer amplified sequence 2.(Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.) 15694360,ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor.(Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.) 15047147
E2F1 (1869) Chen 3 Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage.(Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.) 16892051,Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism.(Molecular Oncology Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 33612, USA.) 15713665,ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance.(Department of Biological Chemistry, School of Medicine, UCD Cancer Center/Basic Science, University of California at Davis, Sacramento, CA 95817, USA.) 15169882
E2F1 (1869) Kowalik 3 Rb inactivation leads to E2F1-mediated DNA double-strand break accumulation.(Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, UMass Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655, USA.) 16186801,E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts.(Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, 01655, USA.) 16434972,Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2.(Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.) 15024084
E2F1 (1869) Zhang 2 Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway.(Department of Pharmacology and Toxicology and Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.) 16170383,Novel MDM2 p53-independent functions identified through RNA silencing technologies.(Department of Pharmacology and Toxicology and Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.) 16394138
E2F1 (1869) Johnson 2 Oncogenes and the DNA damage response: Myc and E2F1 engage the ATM signaling pathway to activate p53 and induce apoptosis.(The University of Texas MD Anderson Cancer Center, Science Park Research Division, Department of Carcinogenesis, Smithville, Texas, USA.) 16582589,E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis.(Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, USA.) 15140942
E2F1 (1869) Kelley 2 Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis.(Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA.) 14681231,IL-1beta suppresses prolonged Akt activation and expression of E2F-1 and cyclin A in breast cancer cells.(Laboratory of Immunophysiology, University of Illinois, Urbana, IL 61801, USA.) 15187102
E2F1 (1869) Koeffler 2 C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation.(Cedars-Sinai Medical Center, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, CA 90048, USA. gro.shsc|syreg#gro.shsc|syreg) 15674331,C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis.(Cedars-Sinai Medical Center, Davis Bldg 5066, 8700 Beverly Blvd, Los Angeles, CA 90048, USA. gro.shsc|syreg#gro.shsc|syreg) 12947005
E2F1 (1869) Lu 2 ASPP1 and ASPP2 are new transcriptional targets of E2F.(Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK.) 15731768,Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315.(Ludwig Institute for Cancer Research, University College London Branch, London, UK.) 16037820
E2F1 (1869) Ginsberg 2 Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F.(Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.) 15706352,Transcriptional regulation of AKT activation by E2F.(Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.) 15574337
Unless otherwise stated, the content of this page is licensed under Creative Commons Attribution-Share Alike 2.5 License.