TF Author Nr1I3 To ZHX1
Gene ID Last Name Gene2PubmedReferences (2003 or more recent) Gene2Pubmed Links
NR1I3 (9970) Goldstein 2 The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter.(Human Metabolism Section, Laboratory of Pharmacology and Chemistry, National Institutes of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.) 15919766,Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha.(Laboratory of Pharmacology & Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.) 15933212
NR1I3 (9970) Moore 2 Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor.(Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.) 15831521,Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR.(Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.) 15272053
NR2E3 (10002) Swaroop 2 Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors.(Neuroscience Graduate Program, Department of Opthalmology and Visual Sciences, University of Michigan, Ann Arbor 48105, USA.) 15190009,Mutation analysis of NR2E3 and NRL genes in Enhanced S Cone Syndrome.(MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom. ku.crm.ugh|thgirw.nala#ku.crm.ugh|thgirw.nala) 15459973
NR2F2 (7026) Saruta 2 Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription.(Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160-8582, Japan.) 15611122,COUP-TF and transcriptional co-regulators in adrenal steroidogenesis.(Health Center, Keio University, Tokyo, Japan. pj.en.ten-os.3bc|504-orih#pj.en.ten-os.3bc|504-orih) 15666827
NR3C1 (2908) Chrousos 3 A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity.(Department of Pediatric Endocrinology, Great Ormond Street Hospital for Children, 9th Floor, Southwood Building, Great Ormond Street, London, United Kingdom WC1N 3JH. vog.hin.liam|enamrahc#vog.hin.liam|enamrahc) 15769988,G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus.(Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. vog.hin.liam|tonik#vog.hin.liam|tonik) 15955845,Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?(Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1583, USA. vog.hin.liam|tonik#vog.hin.liam|tonik) 15265780
NR3C1 (2908) Cidlowski 2 Functional analysis of the LXXLL motifs of the human glucocorticoid receptor: association with altered ligand affinity.(Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, United States.) 16914312,Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes.(Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.) 15866175
NR3C1 (2908) Kino 2 The human glucocorticoid receptor (hGR) beta isoform suppresses the transcriptional activity of hGRalpha by interfering with formation of active coactivator complexes.(Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Building 10, Room 9D42, Bethesda, Maryland 20892-1583, USA. vog.hin.liam|enamrahc#vog.hin.liam|enamrahc) 15459252,Intracellular glucocorticoid signaling: a formerly simple system turns stochastic.(Department of Pediatrics, University of Athens, Athens 115 27, Greece. rg.aou.dem|egsuorhc#rg.aou.dem|egsuorhc) 16204701
NR3C1 (2908) Lamberts 2 Glucocorticoid receptor polymorphism affects transrepression but not transactivation.(Erasmus Medical Center, Department of Internal Medicine, Room Ee 585, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.) 16684836,The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults.(Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. ln.cmsumsare|mussornav.e#ln.cmsumsare|mussornav.e) 15292341
NR3C1 (2908) Stangl 2 The pregnancy hormone relaxin binds to and activates the human glucocorticoid receptor.(Charité Berlin, Campus Mitte, Medizinische Klinik m. S. Kardiologie, Angiologie und Pulmologie, Schumannstr. 20/21, 10117 Berlin, Germany. ed.enilno-t|gizteihcsd.samoht#ed.enilno-t|gizteihcsd.samoht) 15956716,Identification of the pregnancy hormone relaxin as glucocorticoid receptor agonist.(Medizinische Klinik m. S. Kardiologie, Angiologie, Pulmologie, Charité Berlin, Berlin, Germany. ed.enilno-t|gizteihcsd.samoht#ed.enilno-t|gizteihcsd.samoht) 15289446
NR3C1 (2908) Thompson 2 Activation function 1 of glucocorticoid receptor binds TATA-binding protein in vitro and in vivo.(Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555-1068, USA.) 16469772,TATA box binding protein induces structure in the recombinant glucocorticoid receptor AF1 domain.(Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555, USA.) 15545613
NR3C1 (2908) Vedeckis 4 Interaction between the interferon signaling pathway and the human glucocorticoid receptor gene 1A promoter.(Department of Biochemistry and Molecular Biology and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, 533 Bolivar Street, New Orleans, Louisiana 70112, USA.) 15576464,Human glucocorticoid receptor alpha transcript splice variants with exon 2 deletions: evidence for tissue- and cell type-specific functions.(Department of Biochemistry and Molecular Biology and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.) 15895983,c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter.(Department of Biochemistry and Molecular Biology and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.) 16263717
NR3C1 (2908) Weiner 2 The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 16429131,Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 15832179
NR3C1 (2908) Yamamoto 2 The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression.(Department of Cellular and Molecular Pharmacology, University of California-San Francisco, San Francisco, CA 94107-2280, USA.) 15879558,Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes.(Departments of Cellular and Molecular Pharmacology and Medicine, University of California-San Francisco, S572D, Genentech Hall, 600 16th Street, San Francisco, CA 94107-2280, USA.) 15501915
NR3C2 (4306) Lombès 2 Enhancement of beta-adrenergic cAMP-signaling by the mineralocorticoid receptor.(Institute of Clinical Pharmacology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1, D-68135 Mannheim, Germany. ed.oohay|leahcim_tsirhc#ed.oohay|leahcim_tsirhc) 15713533,Human mineralocorticoid receptor A and B protein forms produced by alternative translation sites display different transcriptional activities.(INSERM U478, IFR Claude Bernard, Faculté de Médecine Xavier Bichat, 75870 Paris cedex 18, France.) 15080790
NR4A1 (3164) Denis 2 Inhibition of apoptosis by Nur77 through NF-kappaB activity modulation.(1INRS-Institut Armand-Frappier, Laval, QC, Canada.) 16082387,Nur77 forms novel nuclear structures upon DNA damage that cause transcriptional arrest.(INRS-Institut Armand-Frappier, 531 Boulevard des Prairies, Laval (QC), Canada H7V 1B7.) 16480977
NR4A1 (3164) de Vries 2
NR4A1 (3164) Lee 2 Negative cross-talk between Nur77 and small heterodimer partner and its role in apoptotic cell death of hepatoma cells.(College of Pharmacy, Seoul National University, San 56-1 Sillim, Kwanak, Seoul 151-742, Korea.) 15625237,Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha.(Department of Bioscience and Biotechnology, Sejong University, Seoul 143-747, Korea.) 15385570
NR4A1 (3164) Youn 3 A novel function of Nur77: physical and functional association with protein kinase C.(Department of Biochemistry and Molecular Biology, Cancer Research Institute, Interdisciplinary Program in Genetic Engineering, Seoul National University College of Medicine, 28 Yongon-dong, Chongro-gu, Seoul 110-799, Republic of Korea.) 16904076,Menin represses JunD transcriptional activity in protein kinase C theta-mediated Nur77 expression.(Department of Biochemistry and Molecular Biology, Cancer Research Institute, Seoul National University, College of Medicine, 28 Yongon-dong, Chongro-gu, Seoul 110-799, Korea.) 16264271,Nur77 activated by hypoxia-inducible factor-1alpha overproduces proopiomelanocortin in von Hippel-Lindau-mutated renal cell carcinoma.(Department of Biochemistry and Molecular Biology, Cancer Research Institute, Seoul, South Korea.) 14729605
NR4A1 (3164) Zhang 3 Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt.(Burnham Institute for Medical Research, Cancer Center, La Jolla, CA 92037, USA.) 16434970,Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3.(The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.) 14980220,Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected by modulating its nuclear export and mitochondrial targeting.](The Burnham Institute, Cancer Center, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, USA.) 15509776
NR4A2 (4929) 2
NR4A3 (8013) Badimon 2 NOR-1 is involved in VEGF-induced endothelial cell growth.(Centro de Investigación Cardiovascular, CSIC/ICCC, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret # 167, Barcelona 8025, Spain.) 15949808,Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB.(Centro de Investigación Cardiovascular, CSIC/ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.) 14962944
NR5A1 (2516) Achermann 2 Analysis of DAX1 (NR0B1) and steroidogenic factor-1 (NR5A1) in children and adults with primary adrenal failure: ten years' experience.(UCL Institute of Child Health and Department of Medicine, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom.) 16684822,Steroidogenic factor-1 (SF-1) and its relevance to pediatric endocrinology.(UCL Institute of Child Health & Department of Medicine, University College London, UK.) 16816804
NR5A1 (2516) Miller 2 LBP proteins modulate SF1-independent expression of P450scc in human placental JEG-3 cells.(Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143-0978, USA.) 15471945,Regulation of cytochrome b5 gene transcription by Sp3, GATA-6, and steroidogenic factor 1 in human adrenal NCI-H295A cells.(Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143-0978, USA.) 15831526
NR5A1 (2516) Ogata 2 Association of cryptorchidism with Gly146Ala polymorphism in the gene for steroidogenic factor-1.(Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan.) 16500365,Association of severe micropenis with Gly146Ala polymorphism in the gene for steroidogenic factor-1.(Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo.) 16127213
NR5A2 (2494) Attia 2 The orphan nuclear receptor, liver receptor homolog-1, regulates cholesterol side-chain cleavage cytochrome p450 enzyme in human granulosa cells.(Division of Reproductive Endocrinology and Infertility, Cedars Medical Center, 1400 NW 12th Avenue, East Building 4th floor, Miami, Florida 33136, USA.) 15613430,Liver receptor homolog-1 regulates the expression of steroidogenic acute regulatory protein in human granulosa cells.(Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9032, USA.) 15181096
NRF1 (4899) Huang 2 A novel function of transcription factor alpha-Pal/NRF-1: increasing neurite outgrowth.(Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan 701, Taiwan.) 15992771,Alpha-Pal/NRF-1 regulates the promoter of the human integrin-associated protein/CD47 gene.(Institute of Basic Medical Sciences, National Cheng Kung University, Medical College, Tainan 701, Taiwan.) 14747477
NRF1 (4899) Pak 2 In vitro methylation of nuclear respiratory factor-1 binding site suppresses the promoter activity of mitochondrial transcription factor A.(Asan Institute for Life Sciences, Department of Internal Medicine, College of Medicine, University of Ulsan, Seoul, South Korea.) 14715254,Regulation of mitochondrial transcription factor A expression by high glucose.(Asan Institute for Life Sciences, University of Ulsan, Seoul 138-736, Korea.) 15126285
NRG1 (3084) He 3 Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia.(Bio-X Center, Shanghai Jiao Tong University, Shanghai, China.) 16687441,Polymorphisms within 5' end of the Neuregulin 1 gene are genetically associated with schizophrenia in the Chinese population.() 14647391,A case control and family based association study of the neuregulin1 gene and schizophrenia.() 14729827
NRG1 (3084) Weinberger 2 Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease.(Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom. ku.ca.xo.hcysp|wal.adnama#ku.ca.xo.hcysp|wal.adnama) 16618933,Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia.(Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, MD 20892, USA.) 14569272
NRL (4901) Swaroop 3 Retinoic acid regulates the expression of photoreceptor transcription factor NRL.(Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan 48105, USA, and Translational Research Center, Kyoto University Hospital, Japan.) 16854989,The minimal transactivation domain of the basic motif-leucine zipper transcription factor NRL interacts with TATA-binding protein.(Department of Ophthalmology, WK Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105, USA.) 15328344,Mutation analysis of NR2E3 and NRL genes in Enhanced S Cone Syndrome.(MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom. ku.crm.ugh|thgirw.nala#ku.crm.ugh|thgirw.nala) 15459973
OLIG2 (10215) Rowitch 3 Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube.(Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA. ude.llenroc.dem|9002sat#ude.llenroc.dem|9002sat) 16469306,Development of NG2 neural progenitor cells requires Olig gene function.(Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA. ude.dravrah.icfd|nogil_htiek#ude.dravrah.icfd|nogil_htiek) 16682644,The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas.(Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.) 15198128
OLIG2 (10215) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
PAX2 (5076) Camussi 2 Expression of Pax2 in human renal tumor-derived endothelial cells sustains apoptosis resistance and angiogenesis.(Dipartimento di Medicina Interna, Cattedra di Nefrologia, Torino, Italy.) 16436683,Role of Pax2 in apoptosis resistance and proinvasive phenotype of Kaposi's sarcoma cells.(Cattedra di Nefrologia, Dipartimento di Medicina Interna and Centro Ricerca Medicina Sperimentale, Università di Torino, Torino 10126, Italy.) 14627715
PAX2 (5076) Goodyer 2 PAX2 inactivation enhances cisplatin-induced apoptosis in renal carcinoma cells.(Experimental Medicine McGill University, Montreal, QC, Canada H3A 1A3.) 16609680,Neuronal apoptosis inhibitory protein is expressed in developing kidney and is regulated by PAX2.(Department of Human Genetics, McGill University, Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada.) 16735463
PAX3 (5077) Barr 2 Co-expression of alternatively spliced forms of PAX3, PAX7, PAX3-FKHR and PAX7-FKHR with distinct DNA binding and transactivation properties in rhabdomyosarcoma.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 15688409,Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.) 15184910
PAX6 (5080) Hanson 2 PAX6 mutations: genotype-phenotype correlations.(Molecular Medicine Centre, Western General Hospital, School of Molecular and Clinical Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK. ku.ca.de.sms|ikaluozt.i#ku.ca.de.sms|ikaluozt.i) 15918896,A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11.(University of Edinburgh, School of Molecular and Clinical Medicine, Medical Sciences (Medical Genetics), Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU. ku.ca.de|repooc.t.nomis#ku.ca.de|repooc.t.nomis) 16098226
PAX6 (5080) Nakafuku 2 The Pax6 isoform bearing an alternative spliced exon promotes the development of the neural retinal structure.(Department of Ophthalmology, National Center for Child Health and Developent, Tokyo, Japan. pj.og.dhccn|n-amuza#pj.og.dhccn|n-amuza) 15677484,Transdifferentiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor.(Department of Ophthalmology, National Center for Child Health and Development, Tokyo 157-8535, Japan. pj.og.dhccn|n-amuza#pj.og.dhccn|n-amuza) 15757974
PAX6 (5080) Sundaresan 3 PAX6 missense mutations associated in patients with optic nerve malformation.(Department of Genetics, Aravind Medical Research Foundation, Madurai, India.) 16604056,Identification of novel mutant PAX6 alleles in Indian cases of familial aniridia.(Department of Genetics, Aravind Medical Research Foundation, Madurai, India. moc.liamffider|najarihteen#moc.liamffider|najarihteen) 16803629,PAX6 gene variations associated with aniridia in south India.(Department of Genetics, Aravind Medical Research Foundation, Madurai, India. gro.dnivara|najarihteen#gro.dnivara|najarihteen) 15086958
PAX7 (5081) Barr 2 Co-expression of alternatively spliced forms of PAX3, PAX7, PAX3-FKHR and PAX7-FKHR with distinct DNA binding and transactivation properties in rhabdomyosarcoma.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 15688409,Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.) 15184910
PAX7 (5081) Horst 2 Getting the proto-Pax by the tail.(Institut für Humangenetik, UKM, Vesaliusweg 12-14, D-48149, Münster, Germany.) 16830101,Expression of two protein isoforms of PAX7 is controlled by competing cleavage-polyadenylation and splicing.(Institut für Humangenetik, Universitätsklinikum, Münster, Germany.) 15527970
PAX8 (7849) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
PAX8 (7849) Zannini 3 Functional inactivation of the transcription factor Pax8 through oligomerization chain reaction.(Istituto di Endocrinologia ed Oncologia Sperimentale-Consiglio Nazionale delie Ricerche and Dipartimento di Biologia e Patologia Cellulare e Molecolare, Italy.) 16613988,WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8.(Istituto di Endocrinologia ed Oncologia Sperimentale-CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita' di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy.) 14531730,TAZ interacts with TTF-1 and regulates expression of surfactant protein-C.(Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.) 14970209
PAX9 (5083) D'Souza 2 Functional consequences of interactions between Pax9 and Msx1 genes in normal and abnormal tooth development.(Department of Orthodontics, University of Texas Health Science Center at Houston-Dental Branch, Houston, Texas 77030, USA.) 16651263,Functional analysis of a mutation in PAX9 associated with familial tooth agenesis in humans.(Department of Orthodontics, Dental Branch, University of Texas Health Science Center, Houston, Texas 77030, USA.) 14607846
PBX1 (5087) LeBrun 2 Critical role for a single leucine residue in leukemia induction by E2A-PBX1.(Division of Cancer Biology and Genetics, Cancer Research Institute, Queen's University, Kingston, Ontario K7L 3N6, Canada.) 16914730,E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells.(Queen's University Cancer Research Institute, Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, K7L 3N6, Canada.) 15507449
PGR (5241) Lin 2 A novel antiestrogenic mechanism in progesterone receptor-transfected breast cancer cells.(School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, USA.) 15728178,Glucocorticoid and mineralocorticoid cross-talk with progesterone receptor to induce focal adhesion and growth inhibition in breast cancer cells.(Department of Clinical Research, Singapore General Hospital, 637616.) 14617569
PGR (5241) Nardulli 2 Fos and Jun inhibit estrogen-induced transcription of the human progesterone receptor gene through an activator protein-1 site.(Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801, USA.) 14684847,Differential regulation of the human progesterone receptor gene through an estrogen response element half site and Sp1 sites.(Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, IL 61801, USA.) 15084343
PGR (5241) Weigel 2 Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator.(Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.) 15601848,Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity.(Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.) 15798179
PHOX2A (401) Lewis 2 ERK1/2 is a negative regulator of homeodomain protein Arix/Phox2a.(Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland, Oregon 97239, USA.) 16156742,Phox2 and dHAND transcription factors select shared and unique target genes in the noradrenergic cell type.(Department of Biochemistry and Molecular Biology, Oregon Health and Sciences University, Portland, OR, USA.) 16280598
PHOX2B (8929) Amiel 3 PHOX2B genotype allows for prediction of tumor risk in congenital central hypoventilation syndrome.(Unité de Recherches sur les Handicaps Génétiques de l'Enfant INSERM U-393, Département de Génétique, Hôpital Necker-Enfants Malades, Paris, France.) 15657873,Molecular consequences of PHOX2B missense, frameshift and alanine expansion mutations leading to autonomic dysfunction.(Université Paris-Descartes, Faculté de Médecine; INSERM; AP-HP, Hôpital Necker-Enfants Malades, INSERM U-393, Paris, France.) 16249188,Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma.(Unité de Recherches sur les Handicaps Génétiques de l'Enfant, INSERM U-393, and Département de Génétique, Hôpital Necker-Enfants Malades, Paris, France.) 15024693
PHOX2B (8929) Ceccherini 2 The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells.(Laboratorio di Genetica Molecolare, Istituto Gerolamo Gaslini, 16148 Genova, Italy.) 16402914,An in vitro approach to test the possible role of candidate factors in the transcriptional regulation of the RET proto-oncogene.(Laboratorio di Genetica Molecolare, Istituto G. Gaslini, 16148 Genova, Italy.) 16127999
PITX2 (5308) Russo 2 An unusual class of PITX2 mutations in Axenfeld-Rieger syndrome.(Genetics Program, University of Iowa, Iowa City, Iowa 52242-1109, USA.) 16498627,Cell-specific activation of the atrial natriuretic factor promoter by PITX2 and MEF2A.(Genetics Program, University of Iowa, Iowa City, Iowa 52242, USA.) 15466416
PLAGL1 (5325) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
PML (5371) Ahn 3 Requirement of the coiled-coil domain of PML-RARalpha oncoprotein for localization, sumoylation, and inhibition of monocyte differentiation.(Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Kyonggido 440-746, Republic of Korea.) 15809060,Ability of the human cytomegalovirus IE1 protein to modulate sumoylation of PML correlates with its functional activities in transcriptional regulation and infectivity in cultured fibroblast cells.(Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, 300 Chunchundong Jangangu, Suwon, Kyonggido 440-746, Korea.) 15163746,Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase.(College of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Korea.) 15273249
PML (5371) Chang 3 A role for PML3 in centrosome duplication and genome stability.(Department of Molecular Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.) 15749021,Promyelocytic leukemia protein 4 induces apoptosis by inhibition of survivin expression.(Department of Molecular Pathology and Department of Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.) 14597622,Androgen suppresses PML protein expression in prostate cancer CWR22R cells.(George Whipple Lab for Cancer Research, Department of Pathology, The Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA.) 14715247
PML (5371) Leppard 2 Interaction of the adenovirus type 5 E4 Orf3 protein with promyelocytic leukemia protein isoform II is required for ND10 disruption.(Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.) 16501113,Isoforms of the promyelocytic leukemia protein differ in their effects on ND10 organization.(Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, U.K.) 15922731
PML (5371) Ley 2 Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells.(Departments of Medicine and Genetics, Division of Oncology, Siteman Cancer Center, Washington University, 660 S. Euclid Ave., Campus Box 8007, St. Louis, MO 63110-1093, USA. ude.ltsuw.mi|yelt#ude.ltsuw.mi|yelt) 15601827,Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.(Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.) 16113082
PML (5371) Pandolfi 7 The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage.(Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, USA.) 15626733,The promyelocytic leukaemia protein tumour suppressor functions as a transcriptional regulator of p63.(Department of Pathology, Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.) 16007146,Cytoplasmic PML function in TGF-beta signalling.(Cancer Biology and Genetics Program, Department of Pathology, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, 1275 York Avenue, New York, New York, 10021, USA.) 15356634
POU2F1 (5451) Blanck 2 Oct-1 DNA binding activity unresponsive to retinoblastoma protein expression prevents MHC class II induction in a non-small cell lung carcinoma cell line.(Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, MDC Box 7, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA.) 16360016,Oct-1 maintains an intermediate, stable state of HLA-DRA promoter repression in Rb-defective cells: an Oct-1-containing repressosome that prevents NF-Y binding to the HLA-DRA promoter.(Department of Biochemistry, College of Medicine, University of South Florida, Tampa, FL 33612, USA.) 15105429
POU2F1 (5451) Mellon 2 The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1.(Department of Reproductive Medicine, University of California, San Diego, La Jolla, California 92093-0674, USA.) 16002402,TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1.(Department of Reproductive Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92903, USA.) 15138251
POU3F2 (5454) Goding 2 Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin.(Signaling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom.) 15024079,The Brn-2 transcription factor links activated BRAF to melanoma proliferation.(Signaling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom.) 15024080
POU4F1 (5457) Latchman 3 Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a.(Medical Molecular Biology Unit, Institute of Child Health, University College London, and Department of Women's and Children's Health, The Whittington Hospital, London, UK.) 16247485,Brn-3a neuronal transcription factor functional expression in human prostate cancer.(Medical Molecular Biology Unit, Institute of Child Health, University College London, London, UK. ku.ca.lcu.hci|ssid.j#ku.ca.lcu.hci|ssid.j) 16276351,The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1.(Medical Molecular Biology Unit, Institute of Child Health, UCL, 30 Guilford Street, London WC1N 1EH, UK. ku.ca.lcu.hci|enyocsag.d#ku.ca.lcu.hci|enyocsag.d) 15021903
PPARA (5465) 2
PPARA (5465) Staels 4 Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis.(Département d'Athérosclérose, Institut Pasteur de Lille, INSERM U545, and Université de Lille 2, Lille, France.) 16511589,Peroxisome proliferator-activated receptor alpha controls cellular cholesterol trafficking in macrophages.(UR 545 Inserm, Institut Pasteur de Lille and Université de Lille 2, Lille, France.) 16162941,PPAR alpha inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a.(INSERM U545, Département d'Athérosclérose, Institut Pasteur de Lille et Faculté de Pharmacie, Université Lille II, Lille, France.) 16239970
PPARD (5467) Carlberg 2 Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators.(Department of Biochemistry, University of Kuopio, Kuopio FIN-70211, Finland.) 15888456,The human peroxisome proliferator-activated receptor delta gene is a primary target of 1alpha,25-dihydroxyvitamin D3 and its nuclear receptor.(Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.) 15890193
PPARD (5467) Grimaldi 2 PPAR delta: an uncompletely known nuclear receptor.(INSERM, U 636, Centre de Biochimie, UFR Sciences, Parc Valrose, Université de Nice-Sophia-Antipolis, Nice, F-06108 France. rf.ecin-uhc|a.hcirnederf#rf.ecin-uhc|a.hcirnederf) 15803109,Roles of peroxisome proliferator-activated receptor delta in skeletal muscle function and adaptation.(Inserm U636, Centre de Biochimie, Parc Valrose, Université de Nice-Sophia Antipolis, 06108 Nice, France.) 15192438
PPARD (5467) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
PPARG (5468) 4
PPARG (5468) Arslan 2 Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma gene in women with polycystic ovary syndrome.(Kirikkale University Faculty of Medicine, Department of Endocrinology and Metabolism, Kirikkale, Turkey. moc.liamtoh|ttrarum#moc.liamtoh|ttrarum) 16785159,Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma gene in first-degree relatives of subjects with polycystic ovary syndrome.(Department of Endocrinology and Metabolism, Faculty of Medicine, Kirikkale University, Turkey. moc.liamtoh|ttrarum#moc.liamtoh|ttrarum) 16316841
PPARG (5468) Chen 2 Polymorphisms of the peroxisome proliferator-activated receptor-gamma and its coactivator-1alpha genes in Chinese women with polycystic ovary syndrome.(Human Genetic Identification Laboratory, Medical School of Nanjing University, Nanjing, China.) 16600233,The effect of high glucose and PPAR-gamma agonists on PPAR-gamma expression and function in HK-2 cells.(Department of Medicine, The University of Sydney, Renal Research Group, Kolling Institute of Medical Research, Royal North Shore Hospital, New South Wales 2065, Australia.) 15113752
PPARG (5468) Ferrell 2 The C161-->T polymorphism in peroxisome proliferator-activated receptor gamma, but not P12A, is associated with insulin resistance in Hispanic and non-Hispanic white women: evidence for another functional variant in peroxisome proliferator-activated receptor gamma.(Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. ude.ttip.negh|tteffom.nasus#ude.ttip.negh|tteffom.nasus) 16253648,Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and body composition in males.(Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.) 15015141
PPARG (5468) Jiang 2 The conserved residue Phe273(282) of PPARalpha(gamma), beyond the ligand-binding site, functions in binding affinity through solvation effect.(Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, China.) 15935279,The localisation and reduction of nuclear staining of PPARgamma and PGC-1 in human breast cancer.(Metastasis and Angiogenesis Research Group, University Deptartment of Surgery, University of Wales College of Medicine, Cardiff, CF14 4XN, UK. ku.ca.fc|lgsniktaw#ku.ca.fc|lgsniktaw) 15254719
PPARG (5468) Karpe 2 The in vivo effects of the Pro12Ala PPARgamma2 polymorphism on adipose tissue NEFA metabolism: the first use of the Oxford Biobank.(Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford OX3 7LJ, UK. ku.ca.xo.pilxo|nat.yrrag#ku.ca.xo.pilxo|nat.yrrag) 16362285,Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma.(Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, OX3 7LJ, UK. ku.ca.xo.pilxo|suresir.flu#ku.ca.xo.pilxo|suresir.flu) 15855323
PPARG (5468) Laakso 2 Common polymorphisms in the PPARgamma2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men.(Department of Public Health Science and General Practice, University of Oulu, Aapistie 1, P.O. Box 5000, Oulu 90014, Finland. if.uluo.tneduts|ivasuomf#if.uluo.tneduts|ivasuomf) 15781195,Effect of the Pro12Ala polymorphism of the PPARg2 gene on serum adiponectin changes.(Department of Public Health Science and General Practice, University of Oulu, Finland. if.uluo.tneduts|ivasuomf#if.uluo.tneduts|ivasuomf) 16230789
PPARG (5468) Palmer 3 Both PPARgamma and PPARdelta influence sulindac sulfide-mediated p21WAF1/CIP1 upregulation in a human prostate epithelial cell line.(Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.) 16091736,Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes.(Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.) 14730381,Cardiovascular risk in type 2 diabetes is associated with variation at the PPARG locus: a Go-DARTS study.(Institute for Cardiovascular Research, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, Scotland.) 15486307
PPARG (5468) Seo 2 Identification of a truncated alternative splicing variant of human PPARgamma1 that exhibits dominant negative activity.(Department of Pharmacology, Gyeongsang Institute of Health Science, College of Medicine, National University, Jinju, Republic of Korea.) 16842753,Phorbol ester potentiates the growth inhibitory effects of troglitazone via up-regulation of PPARgamma in A549 cells.(Department of Pharmacology, Gyeongsang Institute of Health Science, College of Medicine, Gyeongsang National University, Jinju 660-751, Republic of Korea.) 16945329
PPARG (5468) Southgate 2 Role of PPARgamma and EGFR signalling in the urothelial terminal differentiation programme.(Jack Birch Unit of Molecular Carcinogenesis, Department of Biology, University of York YO10 5YW, UK.) 15054105,Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells.(Department of Biology, Jack Birch Unit of Molecular Carcinogenesis, University of York, York, United Kingdom.) 15111325
PROP1 (5626) Brue 2 An uncommon phenotype with familial central hypogonadism caused by a novel PROP1 gene mutant truncated in the transactivation domain.(Laboratoire des Interactions Cellulaires Neuro-Endocriniennes, Unité Mixte de Recherche Centre National de la Recherche Scientifique, Université de la Méditerranée, Institut Fédératif de Recherche Jean-Roche, Faculté de Médecine Nord, Marseille, France.) 15941866,A familial form of congenital hypopituitarism due to a PROP1 mutation in a large kindred: phenotypic and in vitro functional studies.(Laboratoire des Interactions Cellulaires Neuro-Endocriniennes, Unité Mixte de Recherche 6544, Centre de la Recherche Scientifique, Université de la Méditerranée, Institut Fédératif de Recherche Jean-Roche, Faculté de Médecine Nord, Marseille, France.) 15531542
RARA (5914) Kim 2 Differentiation of insulin-producing cells from human neural progenitor cells.(Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA.) 15839736,Transcriptome analysis of human gastric cancer.(Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon , 305-333, Korea.) 16341674
RARA (5914) Ley 2 Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells.(Departments of Medicine and Genetics, Division of Oncology, Siteman Cancer Center, Washington University, 660 S. Euclid Ave., Campus Box 8007, St. Louis, MO 63110-1093, USA. ude.ltsuw.mi|yelt#ude.ltsuw.mi|yelt) 15601827,Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.(Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.) 16113082
RARA (5914) Su 2 Distinct role and functional mode of TR3 and RARalpha in mediating ATRA-induced signalling pathway in breast and gastric cancer cells.(Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, Fujian Province, China.) 14592536,Ubiquitinated or sumoylated retinoic acid receptor alpha determines its characteristic and interacting model with retinoid X receptor alpha in gastric and breast cancer cells.(Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, Fujian Province, China.) 15171703
RARB (5915) Lotan 3 Hypermethylation of the retinoic acid receptor-beta(2) gene in head and neck carcinogenesis.(Departments of Thoracic/Head and Neck Medical Oncology,The University of Texas, MD Anderson Cancer Center, Houston, Texas 77345, USA.) 15014026,Retinoic acid receptor beta2 hypermethylation: implications for prostate cancer detection, prevention, and therapy.() 15217922,Regulation of RARbeta1 expression in head and neck cancer cells by cell density-dependent chromatin remodeling.(Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA. gro.nosrednadm|fessuoye#gro.nosrednadm|fessuoye) 15467435
RARB (5915) Yasui 2 DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage.(Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.) 16128742,DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation.(Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Kasumi, Hiroshima, Japan.) 16134180
RB1 (5925) Chellappan 3 Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors.(Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.) 15735762,Direct binding of apoptosis signal-regulating kinase 1 to retinoblastoma protein: novel links between apoptotic signaling and cell cycle machinery.(Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.) 15210709,Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis.(Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Dr., Tampa, FL 33612, USA.) 15485920
RB1 (5925) Drouin 2 Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription.(Laboratoire de génétique moléculaire, Institut de recherches cliniques de Montréal (IRCM), Montréal, Québec H2W 1R7, Canada.) 15701640,Rb enhances p160/SRC coactivator-dependent activity of nuclear receptors and hormone responsiveness.(Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal, Quebec, Canada.) 15767262
RB1 (5925) Gallie 2 Distinct patterns of expression of the RB gene family in mouse and human retina.(The Division of Cancer Informatics, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, Canada.) 15939381,Retinoblastoma: revisiting the model prototype of inherited cancer.(Institut für Humangenetik, Hufelandstrasse 55, D-45122 Essen, Germany. ed.nesse-inu|nnamhol.rd#ed.nesse-inu|nnamhol.rd) 15264269
RB1 (5925) Hinds 2 Multiple functions of D-type cyclins can antagonize pRb-mediated suppression of proliferation.(Harvard Medical School, Department of Pathology, Boston, Massachusetts, USA.) 15684604,Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma.(Ian Potter Foundation Centre for Cancer Genomics and Predictive Medicine, and Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Center, Victoria, Melbourne, Australia. gro.camretep|samoht.divad#gro.camretep|samoht.divad) 15583032
RB1 (5925) Kitagawa 2 Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner.(Department of Biochemistry 1, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan.) 16343421,Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.(Department of Biochemistry 1, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.) 15577944
RB1 (5925) Koeffler 2 C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation.(Cedars-Sinai Medical Center, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, CA 90048, USA. gro.shsc|syreg#gro.shsc|syreg) 15674331,C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis.(Cedars-Sinai Medical Center, Davis Bldg 5066, 8700 Beverly Blvd, Los Angeles, CA 90048, USA. gro.shsc|syreg#gro.shsc|syreg) 12947005
RB1 (5925) Lee 2 Overexpression of RB1 transcript is significantly correlated with 13q14 allelic imbalance in colorectal carcinomas.(Department of Paediatrics, National University of Singapore, Singapore.) 16570290,Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation.(Division of Diabetes, Endocrinology & Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.) 14645241
RB1 (5925) Longmore 2 Differences in stability of repressor complexes at promoters underlie distinct roles for Rb family members.(Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.) 14737116,Differential regulation of apoptotic genes by Rb in human versus mouse cells.(Department of Medicine, Washington University School of Medicine, 4940 Parkview Place, St Louis, MO 63110, USA.) 15048095
RB1 (5925) Robertson 2 Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase.(Department of Microbiology and the Tumor Virology Program, Abramson Comprehensive Cancer Center, University of Pennsylvania, 201E Johnson Pavilion, Philadelphia, PA 19104, USA.) 16352731,ORF73 of herpesvirus saimiri, a viral homolog of Kaposi's sarcoma-associated herpesvirus, modulates the two cellular tumor suppressor proteins p53 and pRb.(Department of Microbiology and Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 15367600
RB1 (5925) Vogt 2 Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma.(Department of Dermatology, University of Regensburg, Regensburg, Germany. ed.grubsneger-inu.kinilk|hcseor.rednaxela#ed.grubsneger-inu.kinilk|hcseor.rednaxela) 15502804,Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas.(Department of Dermatology, University of Regensburg, Regensburg, Germany. ed.grubsneger-inu.kinilk|hcseor.rednaxela#ed.grubsneger-inu.kinilk|hcseor.rednaxela) 15803180
RELA (5970) Greene 2 NF-kappaB RelA phosphorylation regulates RelA acetylation.(Gladstone Institute of Virology and Immunology, 1650 Owens St., San Francisco, CA 94158, USA. ude.fscu.enotsdalg|nehcl#ude.fscu.enotsdalg|nehcl) 16135789,p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1.(Gladstone Institute of Virology and Immunology and the Department of Medicine, University of California, San Francisco, California 94143-1234, USA.) 15073170
RELA (5970) Kim 2 A magnetic nanoprobe technology for detecting molecular interactions in live cells.(Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.) 15994554,Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB.(Research Center for Biomedicinal Resources and the Division of Life Science, PaiChai University, Daejeon 302-735, Korea.) 14600157
RELA (5970) Kracht 2 Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity.(Institute of Pharmacology, Medical School Hannover, Carl-Neuberg Strasse 1, D-30625 Hannover, Germany.) 15465828,Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.(Institute of Pharmacology, Medical School Hannover, Carl-Neuberg Strasse 1, D-30625 Hannover, Germany.) 15489227
RELA (5970) Li 2 LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit proliferation of glioma cells in vitro by modulating the extracellular signal-regulated kinase/protein kinase B/nuclear factor-kappaB pathway.(Cancer Research Institute, Central South University, Changsha, 410078 Hunan, People's Republic of China.) 16723503,Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human colorectal carcinoma tissue.(Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, Hubei Province, China. moc.anis|gnailgnailuy#moc.anis|gnailgnailuy) 15484295
REST (5978) Majumder 2 Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation.(Department of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Mail 1006, Room S13.8136C, Houston, TX 77030, USA.) 16478988,Many human medulloblastoma tumors overexpress repressor element-1 silencing transcription (REST)/neuron-restrictive silencer factor, which can be functionally countered by REST-VP16.(Brain Tumor Center, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 11, Houston, TX 77030, USA.) 15767543
RORA (6095) Kawai 2 RORalpha1 and RORalpha4 suppress TNF-alpha-induced VCAM-1 and ICAM-1 expression in human endothelial cells.(Cardiovascular Research, Drug Discovery Institute, Nihon Schering KK, 1900-1, Togo Mobara, Chiba 297-0017, Japan. pj.oc.oohay|bbatigim#pj.oc.oohay|bbatigim) 14741380,Rev-erbalpha upregulates NF-kappaB-responsive genes in vascular smooth muscle cells.(Cardiovascular Research, Drug Discovery Institute, Nihon Schering K.K., 1900-1, Togo Mobara, Chiba 297-0017, Japan. pj.oc.gnirehcs|atigimh#pj.oc.gnirehcs|atigimh) 15013753
RUNX1 (861) Hirai 2 AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.(Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, USA.) 14752096,AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis.(Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.) 14966519
RUNX1 (861) Ito 3 Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome.(1Department of Pediatrics, Hirosaki University School of Medicine, Hirosaki, Japan.) 16628190,Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer.(Graduate School of Medical Science, Surgery and Regenerative Medicine, Surgery and Physiology of Digestive System, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kawaramachi-dori, Kyoto 602, Japan. pj.ca.m-upk.otok|arukakas#pj.ca.m-upk.otok|arukakas) 15386419,Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice.(Institute of Molecular and Cell Biology, Singapore.) 15856017
RUNX1 (861) Mann 2 The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor.(Center for Neurobiology and Behavior, Columbia University Medical School, New York, NY 10032, USA.) 15829516,Regulation of tissue inhibitor of metalloproteinase 1 gene transcription by RUNX1 and RUNX2.(Liver Group, Division of Infection, Inflammation, and Repair, University of Southampton Medical School, Southampton General Hospital, Southampton SO16 6YD, United Kingdom.) 15051730
RUNX1 (861) Pedersen-Bjergaard 2 Amplification or duplication of chromosome band 21q22 with multiple copies of the AML1 gene and mutation of the TP53 gene in therapy-related MDS and AML.(Department of Clinical Genetics, Section of Hematology/Oncology, The Juliane Marie Center, Rigshospitalet, Copenhagen, Denmark. kd.hr|akm#kd.hr|akm) 15618958,Mutations of AML1 are common in therapy-related myelodysplasia following therapy with alkylating agents and are significantly associated with deletion or loss of chromosome arm 7q and with subsequent leukemic transformation.(Department of Clinical Genetics, The Chromosome Laboratory, Section of Hematology/Oncology 4052, Juliane Marie Center, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ã, Denmark. kd.hr|sebed#kd.hr|sebed) 15142876
RUNX2 (860) Neil 2 The RUNX genes: gain or loss of function in cancer.(Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, G61 1QH, UK.) 15864279,Conservation and expression of an alternative 3' exon of Runx2 encoding a novel proline-rich C-terminal domain.(Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden, Glasgow G61 1QH, UK.) 15225881
RUNX2 (860) Passaniti 2 Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation.(Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.) 16407259,Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathway.(Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, USA.) 15304489
RUNX2 (860) Westendorf 2 Runx2: a master organizer of gene transcription in developing and maturing osteoblasts.(Graduate Program in Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA.) 16187316,Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation.(Graduate Program in Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.) 15292260
RUNX3 (864) Bae 3 RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD.(Department of Biochemistry, School of Medicine, and Institute for Tumor Research, Chungbuk National University, Cheongju 361-763, South Korea.) 16135801,Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer.(Department of Biochemistry, School of Medicine and Institute for Tumor Research, Chungbuk National University, Cheongju, Republic of Korea.) 14715269,Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.(Department of Biochemistry and Urology, School of Medicine and Institute for Tumor Research, Chungbuk National University, Cheongju 361-763, South Korea.) 15138260
RUNX3 (864) Ito 5 RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells.(Oncology Research Institute, National University Medical Institutes, Institute of Molecular and Cell Biology, Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117592, Singapore.) 16373335,Expression of RUNX3 protein in human esophageal mucosa and squamous cell carcinoma.(Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Yonago, Japan.) 16582583,Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer.(Graduate School of Medical Science, Surgery and Regenerative Medicine, Surgery and Physiology of Digestive System, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kawaramachi-dori, Kyoto 602, Japan. pj.ca.m-upk.otok|arukakas#pj.ca.m-upk.otok|arukakas) 15386419
RUNX3 (864) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
SIM2 (6493) Shimizu 2 Transcription factor single-minded 2 (SIM2) is ubiquitinated by the RING-IBR-RING-type E3 ubiquitin ligases.(Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.) 15963499,A novel nuclear localization signal in the human single-minded proteins SIM1 and SIM2.(Department of Medical Genetics, Kyorin University School of Health Sciences, 146 Miyashita-cho, Hachioji, Tokyo 192-8508, Japan.) 14697214
SMAD3 (4088) Kim 3 A novel E1A-like inhibitor of differentiation (EID) family member, EID-2, suppresses transforming growth factor (TGF)-beta signaling by blocking TGF-beta-induced formation of Smad3-Smad4 complexes.(Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892-5055, USA.) 14612439,Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer.(Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, MD 20892-5055, USA.) 14647420,Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells.(Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, MD 20892-5055, USA.) 15107418
SMAD3 (4088) Liu 4 Transforming growth factor beta suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene.(Department of Immunology and Monash Institute of Medical Research, Monash University, Melbourne, Victoria 3181, Australia.) 16785237,Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3.(Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, USA.) 16156666,Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3).(Center for Advanced Biotechnology and Medicine, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.) 14691252
SMAD3 (4088) Okazaki 2 Acceleration of Smad2 and Smad3 phosphorylation via c-Jun NH(2)-terminal kinase during human colorectal carcinogenesis.(Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan.) 15665291,TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions.(Third Department of Internal Medicine, Kansai Medical University, 10-15 Fumizonocho, Moriguchi, Osaka 570-8507, Japan.) 15326485
SMAD3 (4088) Souchelnytskyi 2 TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage.(Ludwig Institute for Cancer Research, Box 595, Biomedical Center, SE-751 24 Uppsala, Sweden.) 15735739,Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity.(Ludwig Institute for Cancer Research, Box 595, BMC, SE-751 24, Uppsala, Sweden.) 15527767
SMAD3 (4088) Wang 3 Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells.(Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.) 16543220,Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathways.(Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA.) 15051726,Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1.(Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA. moc.liamtoh|yrruon_erialc#moc.liamtoh|yrruon_erialc) 15144564
SMYD3 (64754) Nakamura 2 A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers.(Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.) 16155568,SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.(Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.) 15235609
SNAI1 (6615) García de Herreros 2
SNAI2 (6591) Chaudhuri 2 Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells.(Division of Cancer Biology, Department of Biomedical Sciences, Meharry Medical College, Vanderbilt University Medical Center, Nashville, Tennessee 37208, USA.) 15734731,Negative regulation of the expressions of cytokeratins 8 and 19 by SLUG repressor protein in human breast cells.(Division of Cancer Biology, Department of Basic Sciences, Meharry Medical College, Nashville, TN 37208, USA.) 15737616
SOX10 (6663) Kato 2 A family-based and case-control association study of SOX10 in schizophrenia.(Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan. pj.nekir.niarb|otak#pj.nekir.niarb|otak) 16741945,DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia.(Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama 351-0198, Japan. pj.nekir.niarb|otomawizak#pj.nekir.niarb|otomawizak) 15930386
SOX10 (6663) Wegner 3 Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas.(Department of Pathology, Yale University School of Medicine, New Haven, CT 65210, USA. ude.elay|hkynnaB.ieugreS#ude.elay|hkynnaB.ieugreS) 16205963,The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.(Institut für Biochemie, Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany.) 16582099,The high-mobility group transcription factor Sox10 interacts with the N-myc-interacting protein Nmi.(Institut für Biochemie, Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany.) 16214168
SOX2 (6657) Tatematsu 2 Sox2 expression in human stomach adenocarcinomas with gastric and gastric-and-intestinal-mixed phenotypes.(Division of Oncological Pathology, Aichi Cancer Centre Research Institute, Nagoya, Japan. pj.cc-ihcia|tmakustt#pj.cc-ihcia|tmakustt) 15910596,Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia.(Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Nagoya, Chikusa-ku, Japan. pj.cc-ihcia|tmakustt#pj.cc-ihcia|tmakustt) 14655050
SOX2 (6657) Tsutani 2 Histopathologic evaluation of stepwise progression of pancreatic carcinoma with immunohistochemical analysis of gastric epithelial transcription factor SOX2: comparison of expression patterns between invasive components and cancerous or nonneoplastic intraductal components.(Department of Surgical Oncology, Research Institution for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Hiroshima 734-8551, Japan. moc.liamtoh|grusadanasy#moc.liamtoh|grusadanasy) 16552336,Expression of gastric mucin MUC5AC and gastric transcription factor SOX2 in ampulla of vater adenocarcinoma: comparison between expression patterns and histologic subtypes.(Department of Surgical Oncology, Research Institution for Radiation Biology and Medicine, Hiroshima University, Kasumi, Hiroshima, Japan.) 16596179
SOX6 (55553) Toda 2 Expression of a transcriptional factor, SOX6, in human gliomas.(Neuroimmunology Research Group, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.) 15696967,Immunohistochemical analysis of SOX6 expression in human brain tumors.(Neuroimmunology Research Group, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.) 15696972
SOX9 (6662) Asahara 2 Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment.(Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.) 15623506,Sox9 and p300 cooperatively regulate chromatin-mediated transcription.(Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.) 16109717
SOX9 (6662) de Crombrugghe 2
SP1 (6667) Chang 2 O-linked N-acetylglucosamine suppresses thermal aggregation of Sp1.(School of Life Sciences and Biotechnology, Korea University, 5-1 Anam-dong, Seongbuk-gu, Seoul 136-701, Republic of Korea.) 16879824,Hsp90alpha recruited by Sp1 is important for transcription of 12(S)-lipoxygenase in A431 cells.(Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.) 16118214
SP1 (6667) Hung 4 HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion.(Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.) 16377629,p16 inhibits matrix metalloproteinase-2 expression via suppression of Sp1-mediated gene transcription.(Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.) 16575904,1,25-dihydroxyvitamin D3 transcriptionally represses p45Skp2 expression via the Sp1 sites in human prostate cancer cells.(Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, China.) 16883603
SP1 (6667) Kim 3 Transcription factor Sp1 mediates p38MAPK-dependent activation of the p21WAF1 gene promoter in vascular smooth muscle cells by pyrrolidine dithiocarbamate.(National Research Laboratory for Glycobiology, Korean Ministry of Science and Technology, Kyungju, Kyungbuk 780-714, Republic of Korea.) 15033443,Sp1-dependent regulation of the RTP801 promoter and its application to hypoxia-inducible VEGF plasmid for ischemic disease.(Clinical Research Center, College of Medicine, Inha University, Inchon 400-711, Korea.) 15180327,Regulatory elements involved in transcription of the human NeuAcalpha2,3Galbeta1,3GalNAcalpha2,6-sialyltransferase (hST6GalNAc IV) gene.(National Research Laboratory for Glycobiology, Department of Biochemistry and Molecular Biology, College of Oriental Medicine, Dongguk University, Kyungju 780-714, Korea.) 15528990
SP1 (6667) Robertson 2 Expression of alpha V integrin is modulated by Epstein-Barr virus nuclear antigen 3C and the metastasis suppressor Nm23-H1 through interaction with the GATA-1 and Sp1 transcription factors.(Department of Microbiology, The Tumor Virology Program of the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 16631833,Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1.(Department of Microbiology and Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 15367601
SP1 (6667) Safe 3 Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.(Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, College Station, Texas 77843-4466, USA.) 16675542,Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer.(Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, Veterinary Research Building 409, College Station, Texas 77843-4466, USA.) 15637147,Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins.(Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, Texas 77030, USA.) 15345676
SP1 (6667) Sawaya 2 Human immunodeficiency virus type 1 Tat prevents dephosphorylation of Sp1 by TCF-4 in astrocytes.(Department of Neuroscience & Center for Neurovirology, Temple University School of Medicine, 1900 N 12th Street (015-96), Philadelphia, PA 19122, USA.) 16690926,Interplay between HIV-1 Vpr and Sp1 modulates p21(WAF1) gene expression in human astrocytes.(Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA.) 15302882
SP1 (6667) Shih 2 Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1.(Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California 90033, USA.) 16728402,Dual functions of transcription factors, transforming growth factor-beta-inducible early gene (TIEG)2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B gene.(Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA.) 15024015
SP1 (6667) St Clair 2
SP1 (6667) Tamaki 2 Platelet derived growth factor induced tenascin-C transcription is phosphoinositide 3-kinase/Akt-dependent and mediated by Ets family transcription factors.(Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.) 16245312,Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1.(Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.) 15001984
SP1 (6667) Xie 2 Altered expression of transcription factor Sp1 critically impacts the angiogenic phenotype of human gastric cancer.(Shanghai East Hospital Cancer Center, Tongji University, Shanghai, The People's Republic of China.) 16158248,Association between expression of transcription factor Sp1 and increased vascular endothelial growth factor expression, advanced stage, and poor survival in patients with resected gastric cancer.(Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.) 15217947
SP3 (6670) Richert 2 Role of an internal ribosome entry site in the translational control of the human transcription factor Sp3.(Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20057, USA.) 14767558,Human transcription factor Sp3: genomic structure, identification of a processed pseudogene, and transcript analysis.(Department of Microbiology and Immunology, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, DC 20057, USA.) 15474306
SP4 (6671) Safe 2 Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins.(Department of Biochemistry, Texas A&M University, College Station, 77843-4466, USA.) 16574784,Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins.(Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, Texas 77030, USA.) 15345676
SPIB (6689) Blom 2 Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B.(Department of Cell Biology and Histology of the AMC, University of Amsterdam, The Netherlands.) 16317090,The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development.(Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, Netherlands.) 15583020
SREBF1 (6720) Foufelle 2 Long chain fatty acyl-CoA synthetase 5 expression is induced by insulin and glucose: involvement of sterol regulatory element-binding protein-1c.(Inserm Unit 671, Université Paris 6, Centre de Recherches Biomédicales des Cordeliers, 15, rue de l'Ecole de Médecine, 75270 Paris cedex 6, France.) 16198472,SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts.(INSERM Unit 465, University Pierre et Marie Curie, Paris, France.) 15277400
SREBF1 (6720) Osborne 2 Activation domains from both monomers contribute to transcriptional stimulation by sterol regulatory element-binding protein dimers.(Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697-3900, USA.) 15550381,Selective coactivator interactions in gene activation by SREBP-1a and -1c.(Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92612-3900, USA.) 15340088
SREBF1 (6720) Shimano 2 Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells.(Department of Internal Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennodai, Tsukuba, Ibaraki 305-8575, Japan.) 15677507,Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.(Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Toranomon 2-2-2, Minato-ku, Tokyo 105-8470, Japan.) 16055439
SREBF2 (6721) Shyy 2 ATF6 modulates SREBP2-mediated lipogenesis.(Division of Biomedical Sciences, University of California, Riverside, Riverside, CA 92521-0121, USA.) 14765107,Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism.(Division of Biomedical Sciences, University of California, Riverside, Riverside, California 92521, USA.) 15358760
SRF (6722) Olson 2 Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin.(Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA. ude.nretsewhtuostu|uil.gnip-ihz#ude.nretsewhtuostu|uil.gnip-ihz) 16054032,Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression.(Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, Texas 75390-9148, USA.) 15014501
SRY (6736) Weiss 2 SRY and human sex determination: the basic tail of the HMG box functions as a kinetic clamp to augment DNA bending.(Department of Biochemistry, Case School of Medicine, Case Western Reserve University, Cleveland, OH 44106-4935, USA.) 16504207,SRY-directed DNA bending and human sex reversal: reassessment of a clinical mutation uncovers a global coupling between the HMG box and its tail.(Department of Biochemistry, Case School of Medicine, Case Western Reserve University, Cleveland, OH 44106-4935, USA.) 16762365
STAT1 (6772) Chen 3 Structural bases of unphosphorylated STAT1 association and receptor binding.(Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center , The University of Texas, Houston, Texas 77030, USA.) 15780933,Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK.(Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis, Chinese Ministry of Education, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine (formerly Shanghai Second Medical University), Shanghai 200025, China.) 16260419,Crystallization and X-ray crystallographic analysis of human STAT1.(Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Box 117, Houston, TX 77030, USA.) 16511123
STAT1 (6772) Chung 2 Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain.(Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.) 16940534,Hepatitis C virus expression suppresses interferon signaling by degrading STAT1.(Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.) 15825084
STAT1 (6772) Fagard 2 Latent membrane protein 1 regulates STAT1 through NF-kappaB-dependent interferon secretion in Epstein-Barr virus-immortalized B cells.(UPRES EA 34306, Service de Biochimie, AP-HP, Hôpital Avicenne, 125 Rue de Stalingrad, 93009 Bobigny Cedex, France.) 15795279,Differential roles of STAT1alpha and STAT1beta in fludarabine-induced cell cycle arrest and apoptosis in human B cells.(EA 3406 Université Paris 13, Service de Biochimie, Hôpital Avicenne, 125 route de Stalingrad, 93009 Bobigny Cedex, France.) 15217838
STAT1 (6772) Frank 2 Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis.(Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.) 16585190,Oral fludarabine has significant activity in patients with previously untreated chronic lymphocytic leukemia, and leads to increased STAT1 levels in vivo.(James P. Wilmot Cancer Center, University of Rochester, 601 Elmwood Avenue, Box 704, Rochester, NY 14642, USA. ude.retsehcor.cmru|grebdeirf_nahtanoj#ude.retsehcor.cmru|grebdeirf_nahtanoj) 14654078
STAT1 (6772) Ivashkiv 3 Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation.(Arthritis and Tissue Degeneration Program, Department of Medicine, Hospital for Special Surgery, New York, New York 10021, USA.) 16571725,IFN-gamma-primed macrophages exhibit increased CCR2-dependent migration and altered IFN-gamma responses mediated by Stat1.(Arthritis and Tissue Degeneration Program, Department of Medicine, Hospital for Special Surgery, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA.) 16148108,Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors.(Arthritis and Tissue Degeneration Program, Department of Medicine, Hospital for Special Surgery, New York, New York 10021, USA.) 15467722
STAT1 (6772) Stephanou 2 Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury.(Department of Medical Molecular Biology, The Institute of Child Health, University College London, 30 Guilford St., London, WC1N 1EH, UK.) 16935931,STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage.(Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK.) 15784679
STAT1 (6772) Vinkemeier 3 Nuclear export determines the cytokine sensitivity of STAT transcription factors.(Abteilung Zelluläre Signalverarbeitung, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Freie Universität Berlin, 13125 Berlin, Germany.) 16195225,A single residue modulates tyrosine dephosphorylation, oligomerization, and nuclear accumulation of stat transcription factors.(Abteilung Zelluläre Signalverarbeitung, Forschungsinstitut für Molekulare Pharmakologie, Freie Universität Berlin, 13125 Berlin, Germany.) 15010467,Nucleocytoplasmic shuttling by nucleoporins Nup153 and Nup214 and CRM1-dependent nuclear export control the subcellular distribution of latent Stat1.(Abteilung Zellulare Signalverarbeitung, Leibniz-Forschungsinstitut fur Molekulare Pharmakologie, Robert-Rossle-Str. 10, 13125 Berlin, Germany.) 15210729
STAT2 (6773) Fish 2 Identification of GAS-dependent interferon-sensitive target genes whose transcription is STAT2-dependent but ISGF3-independent.(Department of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, ON, Canada.) 16689942,Functional relevance of the conserved DNA-binding domain of STAT2.(Division of Cell & Molecular Biology, Toronto General Research Institute, University Health Network and Department of Immunology, University of Toronto, Toronto, Ontario M5G 2M1, Canada.) 15668228
STAT3 (6774) Chin 3 Stat3 cleavage by caspases: impact on full-length Stat3 expression, fragment formation, and transcriptional activity.(Department of Medicine, Division of Medical Oncology, Brown University and Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA. gro.napsefil|ikswonradj#gro.napsefil|ikswonradj) 16636048,Stat3 dimerization regulated by reversible acetylation of a single lysine residue.(Department of Surgery, Brown University Medical School-Rhode Island Hospital, Providence, RI 02903, USA.) 15653507,Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells.(Department of Surgery Science, Brown University School of Medicine/Rhode Island Hospital, 593 Eddy St., Providence, RI 02903, USA.) 15485908
STAT3 (6774) Friedrich 2 Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth.(Institute of Biochemistry I, Friedrich-Schiller University Jena Medical School, Jena, Germany.) 16036105,Leukemia inhibitory factor triggers activation of signal transducer and activator of transcription 3, proliferation, invasiveness, and altered protease expression in choriocarcinoma cells.(Department of Obstetrics, Friedrich-Schiller-University Jena, Bachstrasse 18, 07740 Jena, Germany.) 16125646
STAT3 (6774) Kitagawa 3 Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2.(Department of Physiology, Osaka City University Graduate School of Medicine, Japan.) 15845643,Selective activation of STAT3 in human monocytes stimulated by G-CSF: implication in inhibition of LPS-induced TNF-alpha production.(Department of Physiology, Osaka City University Medical School, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.) 14736711,Proteolytic conversion of STAT3alpha to STAT3gamma in human neutrophils: role of granule-derived serine proteases.(Department of Physiology, Osaka City University Medical School, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.) 15145953
STAT3 (6774) Lin 3 Evaluation of potential Stat3-regulated genes in human breast cancer.(Center for Childhood Cancer, Columbus Children's Research Institute, The Ohio State University, Columbus, OH 43205, USA.) 16081048,Stat3 modulates heat shock 27kDa protein expression in breast epithelial cells.(Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan Comprehensive Cancer Center, Cellular and Molecular Biology Graduate Program, Ann Arbor, MI 48109-0936, USA.) 14715258,Stat3 upregulates MEK5 expression in human breast cancer cells.(Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cellular and Molecular Biology Graduate Program, University of Michigan Comprehensive Cancer Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109-0936, USA.) 15378007
STAT3 (6774) Luo 2 Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation.(Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.) 15649887,A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells.(Department of Experimental Therapeutics, Biochemistry and Molecular Biology, Immunology, and Molecular Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.) 16061651
STAT3 (6774) Matsuda 2 Physical and functional interactions between Daxx and STAT3.(Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.) 16331268,Nuclear retention of STAT3 through the coiled-coil domain regulates its activity.(Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-Ku Kita 12 Nishi 6, Sapporo 060-0812, Japan.) 16140268
STAT3 (6774) Shaw 2 Bacterial N-acylhomoserine lactone-induced apoptosis in breast carcinoma cells correlated with down-modulation of STAT3.(School of Biomedical Sciences, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.) 15064716,A STAT3 dimer formed by inter-chain disulphide bridging during oxidative stress.(School of Biomedical Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK.) 15336564
STAT3 (6774) Wang 2 RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth.(Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029-6574, USA.) 16382134,Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.(Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, GA 30912, USA.) 16236267
STAT3 (6774) Wasik 2 STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes.(Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 7.103 Founders, Philadelphia, 19104, USA. ude.nnepu.dem.liam|2naiq#ude.nnepu.dem.liam|2naiq) 16861352,STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.(Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.) 15870198
STAT3 (6774) Wong 2 Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: a mechanism requiring PTX-insensitive G proteins, ERK and JNK.(Department of Biochemistry, Molecular Neuroscience Center, and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.) 15979846,Regulation of STAT3 by mu-opioid receptors in human neuroblastoma SH-SY5Y cells.(Department of Biochemistry, the Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.) 15194868
STAT5A (6776) Brizzi 2 {beta}1 Integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation.(Department of Genetics, Biology and Biochemistry, University of Torino, 10126, Torino, Italy. ti.otinu|ippilifed.aloap#ti.otinu|ippilifed.aloap) 15795318,Angiopoietin 2 induces cell cycle arrest in endothelial cells: a possible mechanism involved in advanced plaque neovascularization.(Department of Internal Medicine, University of Torino, Torino, Italy.) 14726409
STAT5A (6776)

ski || 2 ||The influence of STAT5 antisense oligodeoxynucleotides on the proliferation and apoptosis of selected human cutaneous T-cell lymphoma cell lines.(Department of General Pathology, Pomeranian Medical University, Al. PowstaÅ
ców Wlkp. 72, 70-111, Szczecin, Poland. lp.nicezczs.map.dem|akmoizop#lp.nicezczs.map.dem|akmoizop) 16502315,The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.(Department of General Pathology, Pomeranian Medical University, Szczecin, Poland. lp.nicezczs.map.dem|akmoizop#lp.nicezczs.map.dem|akmoizop) 15128421||

STAT5A (6776) Rui 2 Stat5 promotes homotypic adhesion and inhibits invasive characteristics of human breast cancer cells.(Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E504, 3970 Reservoir Rd NW, Washington, DC 20057-1469, USA.) 15592524,Signal transducer and activator of transcription-5 activation and breast cancer prognosis.(Lombardi Comprehensive Cancer Center NRB E504, Georgetown University, 3970 Reservoir Rd NW, Washington, DC 20057-1469, USA.) 15169792
STAT5B (6777) Farrar 2 Restricted STAT5 activation dictates appropriate thymic B versus T cell lineage commitment.(Center for Immunology, Cancer Center, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.) 15944278,STAT5 activation underlies IL7 receptor-dependent B cell development.(Department of Laboratory Medicine and Pathology, Center for Immunology, Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.) 15067053
STAT5B (6777)

ski || 2 ||The influence of STAT5 antisense oligodeoxynucleotides on the proliferation and apoptosis of selected human cutaneous T-cell lymphoma cell lines.(Department of General Pathology, Pomeranian Medical University, Al. PowstaÅ
ców Wlkp. 72, 70-111, Szczecin, Poland. lp.nicezczs.map.dem|akmoizop#lp.nicezczs.map.dem|akmoizop) 16502315,The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.(Department of General Pathology, Pomeranian Medical University, Szczecin, Poland. lp.nicezczs.map.dem|akmoizop#lp.nicezczs.map.dem|akmoizop) 15128421||

STAT6 (6778) Cuber 2 Eotaxin-3/CCL26 gene expression in intestinal epithelial cells is up-regulated by interleukin-4 and interleukin-13 via the signal transducer and activator of transcription 6.(INSERM U45, Faculté de Médecine Laennec, 69372 Lyon Cedex 08, France.) 16084752,IL-4 and IL-13 up-regulate intestinal trefoil factor expression: requirement for STAT6 and de novo protein synthesis.(Institut National de la Santé et de la Recherche Médicale, Unité 45, Faculté de Médecine RTH Laennec, Lyon, France.) 15004182
STAT6 (6778) Pierre 2 Interleukin-4 downregulates TNFalpha-induced IL-8 production in keratinocytes.(INSERM U461, Faculté de Pharmacie, 5 Rue JB Clément, 92296 Chatenay-Malabry, France. rf.dusp-u.pec|duaegniar.leoj#rf.dusp-u.pec|duaegniar.leoj) 16004996,STAT6 and Ets-1 form a stable complex that modulates Socs-1 expression by interleukin-4 in keratinocytes.(INSERM U461, Faculté de pharmacie, 5 Rue J. B. Clément, 92296-Chatenay-Malabry, France.) 15199062
TBX19 (9095) Drouin 2 Congenital isolated adrenocorticotropin deficiency: an underestimated cause of neonatal death, explained by TPIT gene mutations.(Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal, 110 avenue des Pins Ouest, Montréal, Québec, Canada.) 15613420,A neonatal form of isolated ACTH deficiency frequently associated with Tpit gene mutations.(Laboratoire de génétique moléculaire, Institut de Recherches Cliniques de Montréal, Quebec, Canada.) 15666849
TBX21 (30009) Weiss 2 T-bet polymorphisms are associated with asthma and airway hyperresponsiveness.(M.D.C.M., Channing Laboratory, Brigham and Women's Hospital, Boston, MA 02115, USA. ude.dravrah.gninnahc|ybar.nimajneb#ude.dravrah.gninnahc|ybar.nimajneb) 16179640,TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids.(Channing Laboratory and Pulmonary Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. ude.dravrah.gninnahc|arisitnat.nalek#ude.dravrah.gninnahc|arisitnat.nalek) 15604153
TBX2 (6909) Goding 2 Cell cycle regulation of the T-box transcription factor tbx2.(Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, RH8 0TL, UK.) 16730707,Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas.(Signaling and Development Laboratory, Marie Curie Research Institute, Surrey, United Kingdom.) 15781639
TCF12 (6938) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
TCF19 (6941) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.(Human Genome Center, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan. pj.ca.oykot-u.smi|ikuzusy#pj.ca.oykot-u.smi|ikuzusy) 15342556
TGFB1I1 (7041) DeFranco 2 Mechanism of action of Hic-5/androgen receptor activator 55, a LIM domain-containing nuclear receptor coactivator.(Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.) 16141357,Hic-5/ARA55, a LIM domain-containing nuclear receptor coactivator expressed in prostate stromal cells.(Department of Cell Biology and Physiology and Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.) 16849583
TGFB1I1 (7041) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
THRA (7067) Polikarpov 2 Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function.(Instituto de Física de São Carlos, Universidade de São Paulo, Avenida Trabalhador São Carlense, 400 CEP 13560-970 São Carlos, SP, Brazil.) 16781732,Crystallization and preliminary X-ray diffraction studies of isoform alpha1 of the human thyroid hormone receptor ligand-binding domain.(Instituto de Física de São Carlos, Universidade de São Paulo, Av. Trabalhador SãoCarlense 400, São Carlos, SP, 13560-970, Brazil.) 15388935
THRB (7068) Nardulli 2 Interaction of estrogen receptor alpha with 3-methyladenine DNA glycosylase modulates transcription and DNA repair.(Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA.) 14761960,A novel estrogen receptor alpha-associated protein alters receptor-deoxyribonucleic acid interactions and represses receptor-mediated transcription.(Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801, USA.) 15308690
THRB (7068) Yen 2 p62, A TFIIH subunit, directly interacts with thyroid hormone receptor and enhances T3-mediated transcription.(Molecular Regulation and Neuroendocrinology Section, National Institutes of Health, Bethesda, Maryland 20892, USA.) 15625236,Cell cycle-dependent expression of thyroid hormone receptor-beta is a mechanism for variable hormone sensitivity.(Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.) 14767065
TLX1 (3195) Hough 2 Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice.(Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.) 16407851,Loss of Ubr1 promotes aneuploidy and accelerates B-cell lymphomagenesis in TLX1/HOX11-transgenic mice.(Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.) 16862188
TOPORS (10210) Kobarg 2 Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins.(Centro de Biologia Molecular Estrutural, Laboratório Nacional de Luz Síncrotron, Rua Giuseppe Máximo Scolfaro 10.000, C.P. 6192, 13084-971 Campinas, SP, Brazil.) 16455055,CGI-55 interacts with nuclear proteins and co-localizes to p80-coilin positive-coiled bodies in the nucleus.(Centro de Biologia Molecular Estrutural, Laboratório Nacional de Luz Síncrotron, Campinas, SP, Brazil.) 16679534
TOPORS (10210) Rubin 2 The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor.(Department of Pharmacology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA.) 15107820,Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.(Department of Pharmacology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08901, USA.) 15247280
TP53 (7157) Chen 9 GPX2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent manner.(Department of Cell Biology, The University of Alabama at Birmingham, Birmingham, Alabama 35294-0005, USA.) 16446369,DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation.(Department of Cell Biology, The University of Alabama at Birmingham, AL 35294-0005, USA.) 16449651,Myosin VI is a mediator of the p53-dependent cell survival pathway.(Department of Cell Biology, MCLM 660, 1530 3rd Ave. S, Birmingham, AL 35294-0005, USA.) 16507995
TP53 (7157) Fersht 11 The central region of HDM2 provides a second binding site for p53.(Centre for Protein Engineering, Medical Research Council, Hills Road, Cambridge CB2 2QH, United Kingdom.) 16432196,Core domain interactions in full-length p53 in solution.(Medical Research Council Centre for Protein Engineering, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom.) 16461914,Solution structure of p53 core domain: structural basis for its instability.(Medical Research Council Centre for Protein Engineering, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom.) 16461916
TP53 (7157) Harris 5 Tumor suppressor p53 represses transcription of RECQ4 helicase.(Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.) 15674334,Prognostic implications of molecular and immunohistochemical profiles of the Rb and p53 cell cycle regulatory pathways in primary non-small cell lung carcinoma.(Department of Pathology, Cork University Hospital, Cork, Ireland.) 15671551,p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis.(Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892-4255, USA.) 15059885
TP53 (7157) Li 7 Apoptotic DNA fragmentation factor maintains chromosome stability in a P53-independent manner.(Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.) 16619042,Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation.(Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Life Sciences College, Nanjing Normal University, Nanjing 210097, China.) 16753148,Correlation of p53 gene mutation and expression of P53 protein in cholangiocarcinoma.(Department of Hepatobiliary Surgery of Yantai Yuhuangding Hospital, Yantai 264000, Shangdong Province, China. ten.362|436uil#ten.362|436uil) 16937443
TP53 (7157) Liu 7 Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities.(The Hormel Institute, University of Minnesota, Austin, 55912, USA. moc.liamtoh|8861ilwd#moc.liamtoh|8861ilwd) 16501611,Mechanistic insights into maintenance of high p53 acetylation by PTEN.(Department of Biochemistry, University of California, Riverside, Riverside, California 92521, USA.) 16916644,Unique substitution of CHEK2 and TP53 mutations implicated in primary prostate tumors and cancer cell lines.(Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic/Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.) 16941491
TP53 (7157) Lu 6 Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism.(Department of Biochemistry and Molecular Biology, School of Medicine, Oregon Health and Science University, Portland, Oregon 97239.) 16803902,Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315.(Ludwig Institute for Cancer Research, University College London Branch, London, UK.) 16037820,Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation.(Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK.) 15782125
TP53 (7157) Prives 4 Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription.(Department of Biological Sciences, Columbia University, New York, New York 10027, USA.) 16624812,Mutational analysis of the p53 core domain L1 loop.(Department of Biological Sciences, Columbia University, New York, New York 10027, USA.) 16687402,Transcriptional regulation by p53 and p73.(Department of Biological Sciences, Columbia University, New York, New York 10027, USA.) 16869745
TP53 (7157) Wang 6 Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway.(Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan.) 15791651,APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance.(Department of Surgery, Kaohsiung Medical University, Kaohsiung, Taiwan.) 15943410,NMR solution structure of a peptide from the mdm-2 binding domain of the p53 protein that is selectively cytotoxic to cancer cells.(Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, 60 Haven Avenue, New York, New York 10032, USA.) 14967026
TP53 (7157) Wu 8 Analysis of p53 and vascular endothelial growth factor expression in human gallbladder carcinoma for the determination of tumor vascularity.(Department of General Surgery, Second Affiliated Hospital, China Medical University, Shenyang 110004, China. nc.moc.oohay|yt_noegrus#nc.moc.oohay|yt_noegrus) 16489641,Anti-angiogenesis mediated by angiostatin K1-3, K1-4 and K1-4.5. Involvement of p53, FasL, AKT and mRNA deregulation.(Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan, Republic of China.) 16601838,NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.(Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095, USA.) 16697957
TP53 (7157) Zhang 4 The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation.(Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People's Republic of China.) 15611139,Prognostic significance of bcl-2 and p53 expression in colorectal carcinoma.(Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.) 16358373,Inhibition of HDM2 and activation of p53 by ribosomal protein L23.(Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, USA.) 15314174
TSN (7247) Hecht 2 Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation.(Center for Research on Reproduction and Women's Health, University of Pennsylvania School of Medicine, 1310 Biomedical Research Building II/III, 421 Curie Boulevard, Philadelphia, PA 19104-6142, USA.) 14711818,The relative levels of translin-associated factor X (TRAX) and testis brain RNA-binding protein determine their nucleocytoplasmic distribution in male germ cells.(Center for Research on Reproduction and Women's Health, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.) 15138261
TSN (7247) Rao 2 GTP-induced conformational changes in translin: a comparison between human and Drosophila proteins.(Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, India.) 16411762,Co-expressed recombinant human Translin-Trax complex binds DNA.(Synchrotron Radiation Section, Bhabha Atomic Research Centre, Mumbai 400 085, India.) 15919079
UBTF (7343) Shi 2 Compact molten globule-like state of hUBF HMG Box1 at extremely low pH.(School of Life Science, University of Science and Technology of China, People's Republic of China.) 15752694,Structural and dynamic characterization of the acid-unfolded state of hUBF HMG box 1 provides clues for the early events in protein folding.(Hefei National Laboratory for Physical Sciences at Microscale, School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China.) 15924431
UBTF (7343) Zomerdijk 3 RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor.(Division of Gene Regulation and Expression, School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom.) 16809778,UBF activates RNA polymerase I transcription by stimulating promoter escape.(Division of Gene Regulation and Expression, School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee, UK.) 16858408,TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter.(Division of Gene Regulation and Expression, School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Scotland, UK.) 15970593
USF1 (7391) 2
USF1 (7391) Galibert 2 [USF as a key regulatory element of gene expression](CNRS UMR 6061, Laboratoire de génétique et développement, Faculté de Médecine, Université de Rennes 1, France.) 16386222,UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1).(CNRS UMR 6061 Laboratoire de Génétique et Développement, Faculté de Médecine, Université de Rennes-1, 2 Avenue du Pr. Léon Bernard, 35043 Rennes, France.) 15358786
USF1 (7391) Kaetzel 2 Down-regulation of the polymeric immunoglobulin receptor in non-small cell lung carcinoma: correlation with dysregulated expression of the transcription factors USF and AP2.(Department of Pathology and Laboratory Medicine, University of Kentucky College of Medicine, Lexington, KY 40536, USA.) 15864740,Upstream stimulatory factor but not c-Myc enhances transcription of the human polymeric immunoglobulin receptor gene.(Department of Pathology & Laboratory Medicine, University of Kentucky, Lexington, KY 40536, USA.) 14644095
USF1 (7391) Peltonen 3 Risk alleles of USF1 gene predict cardiovascular disease of women in two prospective studies.(Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland.) 16699592,USF1 and dyslipidemias: converging evidence for a functional intronic variant.(Department of Molecular Medicine, National Public Health Institute, Finland.) 16076849,Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).(Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California 90095-7088, USA. ude.alcu.tendem|atnakujapp#ude.alcu.tendem|atnakujapp) 14991056
VDR (7421) Garabédian 2 Vitamin D-resistant rickets and type 1 diabetes in a child with compound heterozygous mutations of the vitamin D receptor (L263R and R391S): dissociated responses of the CYP-24 and rel-B promoters to 1,25-dihydroxyvitamin D3.(INSERM Unité 561, Hôpital St Vincent de Paul, Paris, France. rf.mresni.5sirap|neyugn-iaht#rf.mresni.5sirap|neyugn-iaht) 16753019,The rapid effects of 1,25-dihydroxyvitamin D3 require the vitamin D receptor and influence 24-hydroxylase activity: studies in human skin fibroblasts bearing vitamin D receptor mutations.(CNRS UPR 1524/UMR 8104, Hôpital St Vincent de Paul, 75014 Paris, France. rf.oodanaw|pvs.srnc#rf.oodanaw|pvs.srnc) 14665637
VDR (7421) Todd 2 Associations of patella lead with polymorphisms in the vitamin D receptor, delta-aminolevulinic acid dehydratase and endothelial nitric oxide synthase genes.(Departments of Environmental Health Sciences, Johns Hopkins School of Medicine and Bloomberg School of Public Health, Baltimore, Maryland, USA.) 15213514,Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes.(Juvenile Diabetes Research Foundation/Wellcome Trust DiabetesInflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, WT/MRC building, Addenbrooke's Hospital, Cambridge, CB2 2XY, UK. ku.ca.mac.rmic|vestnejen.yegres#ku.ca.mac.rmic|vestnejen.yegres) 15448105
VDR (7421) Weigel 3 Androgen receptor signaling and vitamin D receptor action in prostate cancer cells.(Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas77030, USA.) 15754350,Vitamin D receptor agonists induce prostatic acid phosphatase to reduce cell growth and HER-2 signaling in LNCaP-derived human prostate cancer cells.(Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.) 16076555,The functional consequences of cross-talk between the vitamin D receptor and ERK signaling pathways are cell-specific.(Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.) 15331595
WT1 (7490) Roberts 2 BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1.(School of Biological Sciences, University of Manchester, G.186 Stopford Building, Oxford Road, Manchester M13 9PT, UK.) 14701728,Transcriptional regulation by the Wilms' tumour suppressor protein WT1.(School of Biological Sciences, The Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK.) 15506928
WT1 (7490) Sugiyama 4 Antiapoptotic function of 17AA(+)WT1 (Wilms' tumor gene) isoforms on the intrinsic apoptosis pathway.(Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.) 16518414,Th1-biased humoral immune responses against Wilms tumor gene WT1 product in the patients with hematopoietic malignancies.(Department of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.) 15538407,Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression.(Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.) 15365188
WT1 (7490) Yasukawa 2 Direct recognition and lysis of leukemia cells by WT1-specific CD4+ T lymphocytes in an HLA class II-restricted manner.(First Department of Internal Medicine, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan.) 15845894,Myeloma cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes.(First Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan.) 15534117
XBP1 (7494) Mori 2 pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response.(Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan. pj.ca.u-otoyk.aidem.xobm.scisyhpoib|edih#pj.ca.u-otoyk.aidem.xobm.scisyhpoib|edih) 16461360,Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II.(Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.) 15598891
YY1 (7528) Bonavida 2 Expression of transcription factor Yin Yang 1 in prostate cancer.(Department of Pathology and Laboratory Medicine, University of California, Los Angeles, 90095, USA.) 15942652,Inhibition of the transcription factor Yin Yang 1 activity by S-nitrosation.(Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine and Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, USA.) 16143308
ZBTB16 (7704) Higashiyama 2 PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate cancer proliferation.(Department of Biochemistry and Molecular Genetics, Ehime University School of Medicine, Shitsukawa, To-on, Ehime, Japan.) 16637071,Roles of charged amino acid residues in the cytoplasmic domain of proHB-EGF.(Division of Biochemistry and Molecular Genetics, Department of Molecular and Cellular Biology, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan.) 15219838
ZBTB33 (10009) Daniel 2 The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin.(Department of Biology, LSB-331, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1.) 15817151,Nuclear import of the BTB/POZ transcriptional regulator Kaiso.(Department of Biology, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.) 15564377
ZFP90 (146198) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
ZHX1 (11244) Wanker 2 A human protein-protein interaction network: a resource for annotating the proteome.(Max Delbrueck Center for Molecular Medicine, 13092 Berlin-Buch, Germany.) 16169070,A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.(Max-Delbrueck-Center for Molecular Medicine, 13125 Berlin-Buch, Germany.) 15383276
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