TF Author Next 210 Results
Gene ID Last Name Gene2PubmedReferences (2003 or more recent) Gene2Pubmed Links
CEBPE (1053) Koeffler 3 C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis.(Cedars-Sinai Medical Center, Davis Bldg 5066, 8700 Beverly Blvd, Los Angeles, CA 90048, USA. gro.shsc|syreg#gro.shsc|syreg) 12947005,Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes.(Division of Hematology/Oncology, Cedars-Sinai Medical Center, University of California at Los Angeles, CA 90048, USA. gro.shsc|syreg#gro.shsc|syreg) 15308577,Protein partners of C/EBPepsilon.(Division of Hematology/Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, Calif. 90048, USA.) 15588942
CEBPB (1051) Kilberg 3 Amino-acid limitation induces transcription from the human C/EBPbeta gene via an enhancer activity located downstream of the protein coding sequence.(Department of Biochemistry and Molecular Biology, Genetics Institute, and Shands Cancer Center, University of Florida College of Medicine, Gainesville, FL 32610, USA.) 16026328,Human CCAAT/enhancer-binding protein beta gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence.(Department of Biochemistry and Molecular Biology, Center for Mammalian Genetics, and Center for Nutritional Sciences, University of Florida College of Medicine, Gainesville, FL 32610-0245, USA.) 15102854,Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone acetylation.(Department of Biochemistry and Molecular Biology, Genetics Institute, and Shands Cancer Center, University of Florida College of Medicine, Gainesville, Florida 32610, USA.) 15385533
CEBPB (1051) Kalvakolanu 3 A role for mixed lineage kinases in regulating transcription factor CCAAT/enhancer-binding protein-{beta}-dependent gene expression in response to interferon-{gamma}.(Greenebaum Cancer Center, Department of Microbiology and Immunology, University of Maryland School of Medicine, Balltimore, MD 21201, USA.) 15878863,IFN-gamma-stimulated transcriptional activation by IFN-gamma-activated transcriptional element-binding factor 1 occurs via an inducible interaction with CAAAT/enhancer-binding protein-beta.(Greenebaum Cancer Center, Department of Microbiology and Immunology, Molecular and Cellular Biology Graduate Program, University of Maryland School of Medicine, Baltimore, MD 21201, USA.) 15879117,Development of monoclonal antibodies against GBF1 and their use in studying its functions.(Greenebaum Cancer Center, Department of Microbiology and Immunology, 655 W. Baltimore Street, University of Maryland School of Medicine, Baltimore, MD 21201, USA.) 16318580
CEBPB (1051) Amini 2 Cooperativity between Rad51 and C/EBP family transcription factors modulates basal and Tat-induced activation of the HIV-1 LTR in astrocytes.(Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA.) 16511829,Cooperative interaction of C/EBP beta and Tat modulates MCP-1 gene transcription in astrocytes.(Center for Neurovirology and Cancer Biology, Temple University, 1900 North 12th Street, 015-96, Room 203, Philadelphia, PA 19122, USA.) 15710476
OLIG2 (10215) Rowitch 3 Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube.(Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA. ude.llenroc.dem|9002sat#ude.llenroc.dem|9002sat) 16469306,Development of NG2 neural progenitor cells requires Olig gene function.(Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA. ude.dravrah.icfd|nogil_htiek#ude.dravrah.icfd|nogil_htiek) 16682644,The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas.(Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.) 15198128
OLIG2 (10215) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
NR1H3 (10062) Tontonoz 3 Phosphorylation of the liver X receptors.(Department of Pathology and Laboratory Medicine, University of California-Los Angeles, CA 90095, USA.) 16904112,Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha.(Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA.) 16170053,Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors.(Howard Hughes Medical Institute, University of California, Los Angeles, California 90095-1662, USA.) 14699103
NR1H3 (10062) Vidal 2 Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells.(INSERM U449, INRA U1235, Laennec Faculty of Medicine, Claude Bernard University of Lyon, Lyon, France.) 16482468,Towards a proteome-scale map of the human protein-protein interaction network.(Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA.) 16189514
NR1I3 (9970) Goldstein 2 The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter.(Human Metabolism Section, Laboratory of Pharmacology and Chemistry, National Institutes of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.) 15919766,Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha.(Laboratory of Pharmacology & Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.) 15933212
NR1I3 (9970) Moore 2 Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor.(Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.) 15831521,Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR.(Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.) 15272053
NR1D1 (9572) Lazar 2 Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock.(Division of Endocrinology, Diabetes, and Metabolism, and University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA.) 16484495,The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene.(Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia 19104-6149, USA.) 15761026
MAPK8IP1 (9479) Lee 2 Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators.(Department of Surgery and Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.) 15911620,Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop.(Department of Surgery and Pharmacology, University of Pittsburgh, Pittsburgh, PA 15213, USA.) 15998799
TBX19 (9095) Drouin 2 Congenital isolated adrenocorticotropin deficiency: an underestimated cause of neonatal death, explained by TPIT gene mutations.(Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal, 110 avenue des Pins Ouest, Montréal, Québec, Canada.) 15613420,A neonatal form of isolated ACTH deficiency frequently associated with Tpit gene mutations.(Laboratoire de génétique moléculaire, Institut de Recherches Cliniques de Montréal, Quebec, Canada.) 15666849
LHX4 (89884) Amselem 2 Functional relationship between LHX4 and POU1F1 in light of the LHX4 mutation identified in patients with pituitary defects.(Institut National de la Santé et de la Recherche Médicale, Unité 654, Hôpital Henri Mondor, 94010 Créteil, France.) 15998782,Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development.(Génétique Moléculaire et Physiopathologie, INSERM U468, Hôpital Henri Mondor, Créteil 94010, France.) 15567726
NR1I2 (8856) Goldstein 2 The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter.(Human Metabolism Section, Laboratory of Pharmacology and Chemistry, National Institutes of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.) 15919766,Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha.(Laboratory of Pharmacology & Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.) 15933212
RUNX2 (860) Neil 2 The RUNX genes: gain or loss of function in cancer.(Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, G61 1QH, UK.) 15864279,Conservation and expression of an alternative 3' exon of Runx2 encoding a novel proline-rich C-terminal domain.(Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden, Glasgow G61 1QH, UK.) 15225881
RUNX2 (860) Passaniti 2 Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation.(Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.) 16407259,Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathway.(Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, USA.) 15304489
RUNX2 (860) Westendorf 2 Runx2: a master organizer of gene transcription in developing and maturing osteoblasts.(Graduate Program in Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA.) 16187316,Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation.(Graduate Program in Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.) 15292260
KLF7 (8609) Maeda 2 Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line.(Laboratory for Diabetic Nephropathy, SNP Research Center, The Institute of Physical and Chemical Research, Kanagawa 230-0045, Japan.) 16339272,Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes.(Laboratory for Diabetic Nephropathy, SNP Research Centre, Institute of Physical and Chemical Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.) 15937668
FOSL1 (8061) Reddy 2 A Phosphatidylinositol 3-kinase-regulated Akt-independent signaling promotes cigarette smoke-induced FRA-1 expression.(Department of Environmental Health Sciences, Bloomberg School of Public Health and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA.) 16490785,Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements.(Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA.) 15806162
NR4A3 (8013) Badimon 2 NOR-1 is involved in VEGF-induced endothelial cell growth.(Centro de Investigación Cardiovascular, CSIC/ICCC, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret # 167, Barcelona 8025, Spain.) 15949808,Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB.(Centro de Investigación Cardiovascular, CSIC/ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.) 14962944
ZBTB16 (7704) Higashiyama 2 PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate cancer proliferation.(Department of Biochemistry and Molecular Genetics, Ehime University School of Medicine, Shitsukawa, To-on, Ehime, Japan.) 16637071,Roles of charged amino acid residues in the cytoplasmic domain of proHB-EGF.(Division of Biochemistry and Molecular Genetics, Department of Molecular and Cellular Biology, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan.) 15219838
YY1 (7528) Bonavida 2 Expression of transcription factor Yin Yang 1 in prostate cancer.(Department of Pathology and Laboratory Medicine, University of California, Los Angeles, 90095, USA.) 15942652,Inhibition of the transcription factor Yin Yang 1 activity by S-nitrosation.(Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine and Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, USA.) 16143308
XBP1 (7494) Mori 2 pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response.(Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan. pj.ca.u-otoyk.aidem.xobm.scisyhpoib|edih#pj.ca.u-otoyk.aidem.xobm.scisyhpoib|edih) 16461360,Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II.(Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.) 15598891
NR1H2 (7376) Tontonoz 2 Phosphorylation of the liver X receptors.(Department of Pathology and Laboratory Medicine, University of California-Los Angeles, CA 90095, USA.) 16904112,Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors.(Howard Hughes Medical Institute, University of California, Los Angeles, California 90095-1662, USA.) 14699103
NR1H2 (7376) Vidal 2 Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells.(INSERM U449, INRA U1235, Laennec Faculty of Medicine, Claude Bernard University of Lyon, Lyon, France.) 16482468,Towards a proteome-scale map of the human protein-protein interaction network.(Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA.) 16189514
TSN (7247) Hecht 2 Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation.(Center for Research on Reproduction and Women's Health, University of Pennsylvania School of Medicine, 1310 Biomedical Research Building II/III, 421 Curie Boulevard, Philadelphia, PA 19104-6142, USA.) 14711818,The relative levels of translin-associated factor X (TRAX) and testis brain RNA-binding protein determine their nucleocytoplasmic distribution in male germ cells.(Center for Research on Reproduction and Women's Health, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.) 15138261
TSN (7247) Rao 2 GTP-induced conformational changes in translin: a comparison between human and Drosophila proteins.(Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, India.) 16411762,Co-expressed recombinant human Translin-Trax complex binds DNA.(Synchrotron Radiation Section, Bhabha Atomic Research Centre, Mumbai 400 085, India.) 15919079
THRB (7068) Yen 2 p62, A TFIIH subunit, directly interacts with thyroid hormone receptor and enhances T3-mediated transcription.(Molecular Regulation and Neuroendocrinology Section, National Institutes of Health, Bethesda, Maryland 20892, USA.) 15625236,Cell cycle-dependent expression of thyroid hormone receptor-beta is a mechanism for variable hormone sensitivity.(Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.) 14767065
THRB (7068) Nardulli 2 Interaction of estrogen receptor alpha with 3-methyladenine DNA glycosylase modulates transcription and DNA repair.(Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA.) 14761960,A novel estrogen receptor alpha-associated protein alters receptor-deoxyribonucleic acid interactions and represses receptor-mediated transcription.(Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801, USA.) 15308690
THRA (7067) Polikarpov 2 Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function.(Instituto de Física de São Carlos, Universidade de São Paulo, Avenida Trabalhador São Carlense, 400 CEP 13560-970 São Carlos, SP, Brazil.) 16781732,Crystallization and preliminary X-ray diffraction studies of isoform alpha1 of the human thyroid hormone receptor ligand-binding domain.(Instituto de Física de São Carlos, Universidade de São Paulo, Av. Trabalhador SãoCarlense 400, São Carlos, SP, 13560-970, Brazil.) 15388935
TGFB1I1 (7041) DeFranco 2 Mechanism of action of Hic-5/androgen receptor activator 55, a LIM domain-containing nuclear receptor coactivator.(Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.) 16141357,Hic-5/ARA55, a LIM domain-containing nuclear receptor coactivator expressed in prostate stromal cells.(Department of Cell Biology and Physiology and Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.) 16849583
TGFB1I1 (7041) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
NR2F2 (7026) Saruta 2 Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription.(Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160-8582, Japan.) 15611122,COUP-TF and transcriptional co-regulators in adrenal steroidogenesis.(Health Center, Keio University, Tokyo, Japan. pj.en.ten-os.3bc|504-orih#pj.en.ten-os.3bc|504-orih) 15666827
TCF19 (6941) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.(Human Genome Center, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan. pj.ca.oykot-u.smi|ikuzusy#pj.ca.oykot-u.smi|ikuzusy) 15342556
TCF12 (6938) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
TBX2 (6909) Goding 2 Cell cycle regulation of the T-box transcription factor tbx2.(Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, RH8 0TL, UK.) 16730707,Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas.(Signaling and Development Laboratory, Marie Curie Research Institute, Surrey, United Kingdom.) 15781639
STAT6 (6778) Pierre 2 Interleukin-4 downregulates TNFalpha-induced IL-8 production in keratinocytes.(INSERM U461, Faculté de Pharmacie, 5 Rue JB Clément, 92296 Chatenay-Malabry, France. rf.dusp-u.pec|duaegniar.leoj#rf.dusp-u.pec|duaegniar.leoj) 16004996,STAT6 and Ets-1 form a stable complex that modulates Socs-1 expression by interleukin-4 in keratinocytes.(INSERM U461, Faculté de pharmacie, 5 Rue J. B. Clément, 92296-Chatenay-Malabry, France.) 15199062
STAT6 (6778) Cuber 2 Eotaxin-3/CCL26 gene expression in intestinal epithelial cells is up-regulated by interleukin-4 and interleukin-13 via the signal transducer and activator of transcription 6.(INSERM U45, Faculté de Médecine Laennec, 69372 Lyon Cedex 08, France.) 16084752,IL-4 and IL-13 up-regulate intestinal trefoil factor expression: requirement for STAT6 and de novo protein synthesis.(Institut National de la Santé et de la Recherche Médicale, Unité 45, Faculté de Médecine RTH Laennec, Lyon, France.) 15004182
STAT5B (6777) Farrar 2 Restricted STAT5 activation dictates appropriate thymic B versus T cell lineage commitment.(Center for Immunology, Cancer Center, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.) 15944278,STAT5 activation underlies IL7 receptor-dependent B cell development.(Department of Laboratory Medicine and Pathology, Center for Immunology, Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.) 15067053
STAT5B (6777)

ski || 2 ||The influence of STAT5 antisense oligodeoxynucleotides on the proliferation and apoptosis of selected human cutaneous T-cell lymphoma cell lines.(Department of General Pathology, Pomeranian Medical University, Al. PowstaÅ
ców Wlkp. 72, 70-111, Szczecin, Poland. lp.nicezczs.map.dem|akmoizop#lp.nicezczs.map.dem|akmoizop) 16502315,The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.(Department of General Pathology, Pomeranian Medical University, Szczecin, Poland. lp.nicezczs.map.dem|akmoizop#lp.nicezczs.map.dem|akmoizop) 15128421||

STAT5A (6776)

ski || 2 ||The influence of STAT5 antisense oligodeoxynucleotides on the proliferation and apoptosis of selected human cutaneous T-cell lymphoma cell lines.(Department of General Pathology, Pomeranian Medical University, Al. PowstaÅ
ców Wlkp. 72, 70-111, Szczecin, Poland. lp.nicezczs.map.dem|akmoizop#lp.nicezczs.map.dem|akmoizop) 16502315,The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.(Department of General Pathology, Pomeranian Medical University, Szczecin, Poland. lp.nicezczs.map.dem|akmoizop#lp.nicezczs.map.dem|akmoizop) 15128421||

STAT5A (6776) Brizzi 2 {beta}1 Integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation.(Department of Genetics, Biology and Biochemistry, University of Torino, 10126, Torino, Italy. ti.otinu|ippilifed.aloap#ti.otinu|ippilifed.aloap) 15795318,Angiopoietin 2 induces cell cycle arrest in endothelial cells: a possible mechanism involved in advanced plaque neovascularization.(Department of Internal Medicine, University of Torino, Torino, Italy.) 14726409
STAT5A (6776) Rui 2 Stat5 promotes homotypic adhesion and inhibits invasive characteristics of human breast cancer cells.(Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E504, 3970 Reservoir Rd NW, Washington, DC 20057-1469, USA.) 15592524,Signal transducer and activator of transcription-5 activation and breast cancer prognosis.(Lombardi Comprehensive Cancer Center NRB E504, Georgetown University, 3970 Reservoir Rd NW, Washington, DC 20057-1469, USA.) 15169792
STAT2 (6773) Fish 2 Identification of GAS-dependent interferon-sensitive target genes whose transcription is STAT2-dependent but ISGF3-independent.(Department of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, ON, Canada.) 16689942,Functional relevance of the conserved DNA-binding domain of STAT2.(Division of Cell & Molecular Biology, Toronto General Research Institute, University Health Network and Department of Immunology, University of Toronto, Toronto, Ontario M5G 2M1, Canada.) 15668228
SRY (6736) Weiss 2 SRY and human sex determination: the basic tail of the HMG box functions as a kinetic clamp to augment DNA bending.(Department of Biochemistry, Case School of Medicine, Case Western Reserve University, Cleveland, OH 44106-4935, USA.) 16504207,SRY-directed DNA bending and human sex reversal: reassessment of a clinical mutation uncovers a global coupling between the HMG box and its tail.(Department of Biochemistry, Case School of Medicine, Case Western Reserve University, Cleveland, OH 44106-4935, USA.) 16762365
SRF (6722) Olson 2 Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin.(Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA. ude.nretsewhtuostu|uil.gnip-ihz#ude.nretsewhtuostu|uil.gnip-ihz) 16054032,Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression.(Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, Texas 75390-9148, USA.) 15014501
SREBF2 (6721) Shyy 2 ATF6 modulates SREBP2-mediated lipogenesis.(Division of Biomedical Sciences, University of California, Riverside, Riverside, CA 92521-0121, USA.) 14765107,Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism.(Division of Biomedical Sciences, University of California, Riverside, Riverside, California 92521, USA.) 15358760
SREBF1 (6720) Foufelle 2 Long chain fatty acyl-CoA synthetase 5 expression is induced by insulin and glucose: involvement of sterol regulatory element-binding protein-1c.(Inserm Unit 671, Université Paris 6, Centre de Recherches Biomédicales des Cordeliers, 15, rue de l'Ecole de Médecine, 75270 Paris cedex 6, France.) 16198472,SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts.(INSERM Unit 465, University Pierre et Marie Curie, Paris, France.) 15277400
SREBF1 (6720) Osborne 2 Activation domains from both monomers contribute to transcriptional stimulation by sterol regulatory element-binding protein dimers.(Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697-3900, USA.) 15550381,Selective coactivator interactions in gene activation by SREBP-1a and -1c.(Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92612-3900, USA.) 15340088
SREBF1 (6720) Shimano 2 Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells.(Department of Internal Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennodai, Tsukuba, Ibaraki 305-8575, Japan.) 15677507,Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.(Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Toranomon 2-2-2, Minato-ku, Tokyo 105-8470, Japan.) 16055439
SPIB (6689) Blom 2 Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B.(Department of Cell Biology and Histology of the AMC, University of Amsterdam, The Netherlands.) 16317090,The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development.(Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, Netherlands.) 15583020
SP4 (6671) Safe 2 Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins.(Department of Biochemistry, Texas A&M University, College Station, 77843-4466, USA.) 16574784,Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins.(Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, Texas 77030, USA.) 15345676
SP3 (6670) Richert 2 Role of an internal ribosome entry site in the translational control of the human transcription factor Sp3.(Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20057, USA.) 14767558,Human transcription factor Sp3: genomic structure, identification of a processed pseudogene, and transcript analysis.(Department of Microbiology and Immunology, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, DC 20057, USA.) 15474306
SOX9 (6662) Asahara 2 Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment.(Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.) 15623506,Sox9 and p300 cooperatively regulate chromatin-mediated transcription.(Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.) 16109717
SOX9 (6662) de Crombrugghe 2
SOX2 (6657) Tatematsu 2 Sox2 expression in human stomach adenocarcinomas with gastric and gastric-and-intestinal-mixed phenotypes.(Division of Oncological Pathology, Aichi Cancer Centre Research Institute, Nagoya, Japan. pj.cc-ihcia|tmakustt#pj.cc-ihcia|tmakustt) 15910596,Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia.(Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Nagoya, Chikusa-ku, Japan. pj.cc-ihcia|tmakustt#pj.cc-ihcia|tmakustt) 14655050
SOX2 (6657) Tsutani 2 Histopathologic evaluation of stepwise progression of pancreatic carcinoma with immunohistochemical analysis of gastric epithelial transcription factor SOX2: comparison of expression patterns between invasive components and cancerous or nonneoplastic intraductal components.(Department of Surgical Oncology, Research Institution for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Hiroshima 734-8551, Japan. moc.liamtoh|grusadanasy#moc.liamtoh|grusadanasy) 16552336,Expression of gastric mucin MUC5AC and gastric transcription factor SOX2 in ampulla of vater adenocarcinoma: comparison between expression patterns and histologic subtypes.(Department of Surgical Oncology, Research Institution for Radiation Biology and Medicine, Hiroshima University, Kasumi, Hiroshima, Japan.) 16596179
SNAI2 (6591) Chaudhuri 2 Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells.(Division of Cancer Biology, Department of Biomedical Sciences, Meharry Medical College, Vanderbilt University Medical Center, Nashville, Tennessee 37208, USA.) 15734731,Negative regulation of the expressions of cytokeratins 8 and 19 by SLUG repressor protein in human breast cells.(Division of Cancer Biology, Department of Basic Sciences, Meharry Medical College, Nashville, TN 37208, USA.) 15737616
SIM2 (6493) Shimizu 2 Transcription factor single-minded 2 (SIM2) is ubiquitinated by the RING-IBR-RING-type E3 ubiquitin ligases.(Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.) 15963499,A novel nuclear localization signal in the human single-minded proteins SIM1 and SIM2.(Department of Medical Genetics, Kyorin University School of Health Sciences, 146 Miyashita-cho, Hachioji, Tokyo 192-8508, Japan.) 14697214
SMYD3 (64754) Nakamura 2 A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers.(Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.) 16155568,SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.(Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.) 15235609
HIF3A (64344) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
RORA (6095) Kawai 2 RORalpha1 and RORalpha4 suppress TNF-alpha-induced VCAM-1 and ICAM-1 expression in human endothelial cells.(Cardiovascular Research, Drug Discovery Institute, Nihon Schering KK, 1900-1, Togo Mobara, Chiba 297-0017, Japan. pj.oc.oohay|bbatigim#pj.oc.oohay|bbatigim) 14741380,Rev-erbalpha upregulates NF-kappaB-responsive genes in vascular smooth muscle cells.(Cardiovascular Research, Drug Discovery Institute, Nihon Schering K.K., 1900-1, Togo Mobara, Chiba 297-0017, Japan. pj.oc.gnirehcs|atigimh#pj.oc.gnirehcs|atigimh) 15013753
BCL6 (604) Melnick 2 ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein.(Department of Medicine, Mount Sinai School of Medicine, One Gustave Levy Pl, New York, NY 10029, USA.) 14551142,Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.(Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.) 15531890
REST (5978) Majumder 2 Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation.(Department of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Mail 1006, Room S13.8136C, Houston, TX 77030, USA.) 16478988,Many human medulloblastoma tumors overexpress repressor element-1 silencing transcription (REST)/neuron-restrictive silencer factor, which can be functionally countered by REST-VP16.(Brain Tumor Center, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 11, Houston, TX 77030, USA.) 15767543
RELA (5970) Li 2 LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit proliferation of glioma cells in vitro by modulating the extracellular signal-regulated kinase/protein kinase B/nuclear factor-kappaB pathway.(Cancer Research Institute, Central South University, Changsha, 410078 Hunan, People's Republic of China.) 16723503,Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human colorectal carcinoma tissue.(Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, Hubei Province, China. moc.anis|gnailgnailuy#moc.anis|gnailgnailuy) 15484295
RELA (5970) Greene 2 NF-kappaB RelA phosphorylation regulates RelA acetylation.(Gladstone Institute of Virology and Immunology, 1650 Owens St., San Francisco, CA 94158, USA. ude.fscu.enotsdalg|nehcl#ude.fscu.enotsdalg|nehcl) 16135789,p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1.(Gladstone Institute of Virology and Immunology and the Department of Medicine, University of California, San Francisco, California 94143-1234, USA.) 15073170
RELA (5970) Kim 2 A magnetic nanoprobe technology for detecting molecular interactions in live cells.(Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.) 15994554,Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB.(Research Center for Biomedicinal Resources and the Division of Life Science, PaiChai University, Daejeon 302-735, Korea.) 14600157
RELA (5970) Kracht 2 Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity.(Institute of Pharmacology, Medical School Hannover, Carl-Neuberg Strasse 1, D-30625 Hannover, Germany.) 15465828,Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.(Institute of Pharmacology, Medical School Hannover, Carl-Neuberg Strasse 1, D-30625 Hannover, Germany.) 15489227
RARA (5914) Su 2 Distinct role and functional mode of TR3 and RARalpha in mediating ATRA-induced signalling pathway in breast and gastric cancer cells.(Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, Fujian Province, China.) 14592536,Ubiquitinated or sumoylated retinoic acid receptor alpha determines its characteristic and interacting model with retinoid X receptor alpha in gastric and breast cancer cells.(Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, Fujian Province, China.) 15171703
RARA (5914) Kim 2 Differentiation of insulin-producing cells from human neural progenitor cells.(Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA.) 15839736,Transcriptome analysis of human gastric cancer.(Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon , 305-333, Korea.) 16341674
RARA (5914) Ley 2 Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells.(Departments of Medicine and Genetics, Division of Oncology, Siteman Cancer Center, Washington University, 660 S. Euclid Ave., Campus Box 8007, St. Louis, MO 63110-1093, USA. ude.ltsuw.mi|yelt#ude.ltsuw.mi|yelt) 15601827,Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.(Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.) 16113082
AHRR (57491) Ogata 2 Association of micropenis with Pro185Ala polymorphism of the gene for aryl hydrocarbon receptor repressor involved in dioxin signaling.(Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan.) 15758562,Association of male infertility with Pro185Ala polymorphism in the aryl hydrocarbon receptor repressor gene: implication for the susceptibility to dioxins.(Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan.) 15474075
AHRR (57491) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
BACH1 (571) Bonkovsky 2 HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells.(Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-1111, USA.) 16530877,Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS.(Department of Medicine and Pharmacology, the General Clinical Research Center of the University of Connecticut Health Center, Farmington, Connecticut 06030, USA. ude.chcu|nahS#ude.chcu|nahS) 15465821
BACH1 (571) Taketani 2 Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells.(Department of Biotechnology, Kyoto Institute of Technology, Kyoto 606-8585, Japan.) 14660636,Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells.(Department of Biotechnology, Kyoto Institute of Technology, Kyoto 606-8585, Japan.) 15464985
PROP1 (5626) Brue 2 An uncommon phenotype with familial central hypogonadism caused by a novel PROP1 gene mutant truncated in the transactivation domain.(Laboratoire des Interactions Cellulaires Neuro-Endocriniennes, Unité Mixte de Recherche Centre National de la Recherche Scientifique, Université de la Méditerranée, Institut Fédératif de Recherche Jean-Roche, Faculté de Médecine Nord, Marseille, France.) 15941866,A familial form of congenital hypopituitarism due to a PROP1 mutation in a large kindred: phenotypic and in vitro functional studies.(Laboratoire des Interactions Cellulaires Neuro-Endocriniennes, Unité Mixte de Recherche 6544, Centre de la Recherche Scientifique, Université de la Méditerranée, Institut Fédératif de Recherche Jean-Roche, Faculté de Médecine Nord, Marseille, France.) 15531542
SOX6 (55553) Toda 2 Expression of a transcriptional factor, SOX6, in human gliomas.(Neuroimmunology Research Group, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.) 15696967,Immunohistochemical analysis of SOX6 expression in human brain tumors.(Neuroimmunology Research Group, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.) 15696972
PPARD (5467) Grimaldi 2 PPAR delta: an uncompletely known nuclear receptor.(INSERM, U 636, Centre de Biochimie, UFR Sciences, Parc Valrose, Université de Nice-Sophia-Antipolis, Nice, F-06108 France. rf.ecin-uhc|a.hcirnederf#rf.ecin-uhc|a.hcirnederf) 15803109,Roles of peroxisome proliferator-activated receptor delta in skeletal muscle function and adaptation.(Inserm U636, Centre de Biochimie, Parc Valrose, Université de Nice-Sophia Antipolis, 06108 Nice, France.) 15192438
PPARD (5467) Carlberg 2 Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators.(Department of Biochemistry, University of Kuopio, Kuopio FIN-70211, Finland.) 15888456,The human peroxisome proliferator-activated receptor delta gene is a primary target of 1alpha,25-dihydroxyvitamin D3 and its nuclear receptor.(Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.) 15890193
PPARD (5467) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
POU3F2 (5454) Goding 2 Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin.(Signaling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom.) 15024079,The Brn-2 transcription factor links activated BRAF to melanoma proliferation.(Signaling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom.) 15024080
POU2F1 (5451) Mellon 2 The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1.(Department of Reproductive Medicine, University of California, San Diego, La Jolla, California 92093-0674, USA.) 16002402,TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1.(Department of Reproductive Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92903, USA.) 15138251
POU2F1 (5451) Blanck 2 Oct-1 DNA binding activity unresponsive to retinoblastoma protein expression prevents MHC class II induction in a non-small cell lung carcinoma cell line.(Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, MDC Box 7, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA.) 16360016,Oct-1 maintains an intermediate, stable state of HLA-DRA promoter repression in Rb-defective cells: an Oct-1-containing repressosome that prevents NF-Y binding to the HLA-DRA promoter.(Department of Biochemistry, College of Medicine, University of South Florida, Tampa, FL 33612, USA.) 15105429
PLAGL1 (5325) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
PITX2 (5308) Russo 2 An unusual class of PITX2 mutations in Axenfeld-Rieger syndrome.(Genetics Program, University of Iowa, Iowa City, Iowa 52242-1109, USA.) 16498627,Cell-specific activation of the atrial natriuretic factor promoter by PITX2 and MEF2A.(Genetics Program, University of Iowa, Iowa City, Iowa 52242, USA.) 15466416
PGR (5241) Lin 2 A novel antiestrogenic mechanism in progesterone receptor-transfected breast cancer cells.(School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, USA.) 15728178,Glucocorticoid and mineralocorticoid cross-talk with progesterone receptor to induce focal adhesion and growth inhibition in breast cancer cells.(Department of Clinical Research, Singapore General Hospital, 637616.) 14617569
PGR (5241) Weigel 2 Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator.(Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.) 15601848,Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity.(Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.) 15798179
PGR (5241) Nardulli 2 Fos and Jun inhibit estrogen-induced transcription of the human progesterone receptor gene through an activator protein-1 site.(Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801, USA.) 14684847,Differential regulation of the human progesterone receptor gene through an estrogen response element half site and Sp1 sites.(Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, IL 61801, USA.) 15084343
LEF1 (51176) Waterman 2 Wnt activation and alternative promoter repression of LEF1 in colon cancer.(Department of Microbiology and Molecular Genetics, Rm. B240, Medical Sciences I, University of California, Irvine, Irvine, CA 92697-4025, USA. ude.icu|mretawlm#ude.icu|mretawlm) 16809766,An internal ribosome entry site mediates translation of lymphoid enhancer factor-1.(Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, CA 92697-4025, USA.) 16120831
LEF1 (51176) Engelhardt 2 Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis.(Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.) 15194563,Characterization of Lef-1 promoter segments that facilitate inductive developmental expression in skin.(Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa 52242-1109, USA.) 15245424
FOXP3 (50943) Levings 2 The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.(Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.) 16211090,Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells.(Department of Surgery, University of British Columbia and Immunity and Infection Centre, Vancouver, BC.) 16339542
FOXP3 (50943) Ziegler 2 Insights into transcriptional regulation by FOXP3.(Department of Immunology, University of Washington, Seattle, WA 98195, USA.) 16368541,Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor.(Benaroya Research Institute, Virginia Mason, Seattle, WA 98101, USA.) 16920951
FOXP3 (50943) Ritz 2 IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo.(Division of Hematologic Malignancies, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA.) 16645171,Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease.(Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA.) 15972448
FOXP3 (50943) Jacobson 2 Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways.(Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.) 16652169,Reduced Foxp3 protein expression is associated with inflammatory disease during human t lymphotropic virus type 1 Infection.(Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.) 16652285
PBX1 (5087) LeBrun 2 Critical role for a single leucine residue in leukemia induction by E2A-PBX1.(Division of Cancer Biology and Genetics, Cancer Research Institute, Queen's University, Kingston, Ontario K7L 3N6, Canada.) 16914730,E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells.(Queen's University Cancer Research Institute, Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, K7L 3N6, Canada.) 15507449
PAX9 (5083) D'Souza 2 Functional consequences of interactions between Pax9 and Msx1 genes in normal and abnormal tooth development.(Department of Orthodontics, University of Texas Health Science Center at Houston-Dental Branch, Houston, Texas 77030, USA.) 16651263,Functional analysis of a mutation in PAX9 associated with familial tooth agenesis in humans.(Department of Orthodontics, Dental Branch, University of Texas Health Science Center, Houston, Texas 77030, USA.) 14607846
PAX7 (5081) Barr 2 Co-expression of alternatively spliced forms of PAX3, PAX7, PAX3-FKHR and PAX7-FKHR with distinct DNA binding and transactivation properties in rhabdomyosarcoma.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 15688409,Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.) 15184910
PAX7 (5081) Horst 2 Getting the proto-Pax by the tail.(Institut für Humangenetik, UKM, Vesaliusweg 12-14, D-48149, Münster, Germany.) 16830101,Expression of two protein isoforms of PAX7 is controlled by competing cleavage-polyadenylation and splicing.(Institut für Humangenetik, Universitätsklinikum, Münster, Germany.) 15527970
PAX3 (5077) Barr 2 Co-expression of alternatively spliced forms of PAX3, PAX7, PAX3-FKHR and PAX7-FKHR with distinct DNA binding and transactivation properties in rhabdomyosarcoma.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 15688409,Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.) 15184910
PAX2 (5076) Camussi 2 Expression of Pax2 in human renal tumor-derived endothelial cells sustains apoptosis resistance and angiogenesis.(Dipartimento di Medicina Interna, Cattedra di Nefrologia, Torino, Italy.) 16436683,Role of Pax2 in apoptosis resistance and proinvasive phenotype of Kaposi's sarcoma cells.(Cattedra di Nefrologia, Dipartimento di Medicina Interna and Centro Ricerca Medicina Sperimentale, Università di Torino, Torino 10126, Italy.) 14627715
PAX2 (5076) Goodyer 2 PAX2 inactivation enhances cisplatin-induced apoptosis in renal carcinoma cells.(Experimental Medicine McGill University, Montreal, QC, Canada H3A 1A3.) 16609680,Neuronal apoptosis inhibitory protein is expressed in developing kidney and is regulated by PAX2.(Department of Human Genetics, McGill University, Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada.) 16735463
NRF1 (4899) Huang 2 A novel function of transcription factor alpha-Pal/NRF-1: increasing neurite outgrowth.(Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan 701, Taiwan.) 15992771,Alpha-Pal/NRF-1 regulates the promoter of the human integrin-associated protein/CD47 gene.(Institute of Basic Medical Sciences, National Cheng Kung University, Medical College, Tainan 701, Taiwan.) 14747477
NRF1 (4899) Pak 2 In vitro methylation of nuclear respiratory factor-1 binding site suppresses the promoter activity of mitochondrial transcription factor A.(Asan Institute for Life Sciences, Department of Internal Medicine, College of Medicine, University of Ulsan, Seoul, South Korea.) 14715254,Regulation of mitochondrial transcription factor A expression by high glucose.(Asan Institute for Life Sciences, University of Ulsan, Seoul 138-736, Korea.) 15126285
NKX3-1 (4824) Bieberich 2 NKX3.1 is regulated by protein kinase CK2 in prostate tumor cells.(Department of Biological Sciences, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA.) 16581776,Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF.(Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250, USA.) 15523673
NFATC2 (4773) Rao 2 FOXP3 controls regulatory T cell function through cooperation with NFAT.(Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA.) 16873067,A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1.(CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.) 15121840
ATF4 (468) Abcouwer 2 The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism.(Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131-0001, USA.) 15788408,Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4.(Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131-0001, USA.) 14747470
ATF3 (467) Baek 2 Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner.(Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.) 16286461,Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner.(Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.) 15670751
ATF3 (467) Kilberg 2 Interaction of RNA-binding proteins HuR and AUF1 with the human ATF3 mRNA 3'-untranslated region regulates its amino acid limitation-induced stabilization.(Department of Biochemistry and Molecular Biology, Genetics Institute, and Shands Cancer Center, University of Florida College of Medicine, Gainesville, Florida 32610, USA.) 16109718,Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone acetylation.(Department of Biochemistry and Molecular Biology, Genetics Institute, and Shands Cancer Center, University of Florida College of Medicine, Gainesville, Florida 32610, USA.) 15385533
ATF3 (467) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
MYOD1 (4654) Schwartz 2 E12 and E47 modulate cellular localization and proteasome-mediated degradation of MyoD and Id1.(Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA.) 16007194,Ubiquitin-Proteasome-mediated degradation of Id1 is modulated by MyoD.(Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St. Louis Children's Hospital, Missouri 63110, USA.) 15163661
MYCN (4613) Ross 2 Loss of one HuD allele on chromosome #1p selects for amplification of the N-myc proto-oncogene in human neuroblastoma cells.(Laboratory of Neurobiology, Department of Biological Sciences, Fordham University, Bronx, NY 10458, USA.) 16278682,Nestin is a potential mediator of malignancy in human neuroblastoma cells.(Laboratory of Neurobiology, Department of Biological Sciences, Fordham University, 441 East Fordham Road, Bronx, NY 10458, USA.) 15117961
NR3C2 (4306) Lombès 2 Enhancement of beta-adrenergic cAMP-signaling by the mineralocorticoid receptor.(Institute of Clinical Pharmacology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1, D-68135 Mannheim, Germany. ed.oohay|leahcim_tsirhc#ed.oohay|leahcim_tsirhc) 15713533,Human mineralocorticoid receptor A and B protein forms produced by alternative translation sites display different transcriptional activities.(INSERM U478, IFR Claude Bernard, Faculté de Médecine Xavier Bichat, 75870 Paris cedex 18, France.) 15080790
MLLT7 (4303) Burgering 2 FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).(Department of Physiological Chemistry, Center for Biomedical Genetics, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands.) 15126506,FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.(Department of Physiological Chemistry, Centre for Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.) 15538382
MLL (4297) Roeder 2 Regulation of MLL1 H3K4 methyltransferase activity by its core components.(Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA.) 16878130,Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.(Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA.) 15960975
MLL (4297) Cleary 2 Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.(Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.) 15199122,Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein.(Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.) 15542854
MEIS1 (4211) Pellerin 2 PBX1 intracellular localization is independent of MEIS1 in epithelial cells of the developing female genital tract.(UMR 6061, Genetique et Developpement, IFR 140, Universite de Rennes 1, Campus Villejean, Rennes, France.) 16172981,A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical' Hoxa9 protein during embryogenesis.(UMR 6061, Génétique et Développement, IFR 97, Université de Rennes 1, Campus Villejean, 2 avenue du Professeur Léon Bernard, CS34317, F-35043 Rennes, France.) 15161102
MEF2A (4205) Wang 2 Advances in the genetic basis of coronary artery disease.(Department of Molecular Cardiology, Lerner Research Institute/ ND4-38, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. gro.fcc|2qgnaw#gro.fcc|2qgnaw) 15811259,Molecular genetics of coronary artery disease.(Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA. gro.fcc|2qgnaw#gro.fcc|2qgnaw) 15861005
PHOX2A (401) Lewis 2 ERK1/2 is a negative regulator of homeodomain protein Arix/Phox2a.(Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland, Oregon 97239, USA.) 16156742,Phox2 and dHAND transcription factors select shared and unique target genes in the noradrenergic cell type.(Department of Biochemistry and Molecular Biology, Oregon Health and Sciences University, Portland, OR, USA.) 16280598
IRF6 (3664) Vikkula 2 Interferon regulatory factor-6: a gene predisposing to isolated cleft lip with or without cleft palate in the Belgian population.(Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology and University of Louvain Medical School, Brussels, Belgium.) 16132054,Six families with van der Woude and/or popliteal pterygium syndrome: all with a mutation in the IRF6 gene.(Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology and Universite catholique de Louvain, Avenue Hippocrate 74+4, Brussels, Belgium.) 14757865
ID2 (3398) Iavarone 2 The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system.(Institute for Cancer Genetics, Department of Pathology, Pediatrics, and Neurology, Columbia University Medical Center, New York, NY 10032, USA.) 16549780,Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.(Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA.) 16810178
CHX10 (338917) Bremner 2 CHX10 targets a subset of photoreceptor genes.(Toronto Western Research Institute, University Health Network, Ontario, Canada.) 16236706,Transcriptional activity of the paired-like homeodomain proteins CHX10 and VSX1.(Toronto Western Research Institute, University Health Network Program, University of Toronto, Toronto, Ontario M5T 2S8, Canada.) 15647262
HOXD10 (3236) Hootnick 2 A HOX gene mutation in a family with isolated congenital vertical talus and Charcot-Marie-Tooth disease.(Department of Clinical Pathology, State University of New York, Upstate Medical University, Syracuse, 13210, USA. ude.etatspu|atpmirhs#ude.etatspu|atpmirhs) 15146389,Congenital vertical talus in four generations of the same family.(Department of Medical Imaging, Crouse Hospital, 736 Irving Ave., Syracuse, NY 13210, USA. moc.rr.yncwt|lme#moc.rr.yncwt|lme) 15368082
HOXB9 (3219) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
HOXB3 (3213) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
HOXA11 (3207) Taylor 2 HOXA10 gene expression in human fallopian tube and ectopic pregnancy.(Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA.) 15167850,The role of HOX genes in human implantation.(Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Yale University School of Medicine, 333 Cedar Street, P.O. Box 2008063, New Haven, CT 06520, USA.) 15731295
HOXA5 (3202) Raman 2 HOXA5 regulates hMLH1 expression in breast cancer cells.(Department of Radiology, Johns Hopkins University School of Medicine, 340 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA.) 16756717,HOXA5-twist interaction alters p53 homeostasis in breast cancer cells.(Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.) 15545268
HOXA5 (3202) Sukumar 2 Identification of transcriptional targets of HOXA5.(Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Hospital, Baltimore, Maryland 21231-1000, USA.) 15757903,HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8.(Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, CRB 410, Baltimore, MD 21231-1000, USA.) 14701762
TLX1 (3195) Hough 2 Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice.(Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.) 16407851,Loss of Ubr1 promotes aneuploidy and accelerates B-cell lymphomagenesis in TLX1/HOX11-transgenic mice.(Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.) 16862188
HNRPK (3190) Cusack 2 X-ray crystallographic and NMR studies of the third KH domain of hnRNP K in complex with single-stranded nucleic acids.(Grenoble Outstation, European Molecular Biology Laboratory, 6 rue Jules Horowitz, BP 181, F-38042 Grenoble Cedex 9, France.) 16004877,Crystallization, microPIXE and preliminary crystallographic analysis of the complex between the third KH domain of hnRNP K and single-stranded DNA.(European Molecular Biology Laboratory, Grenoble Outstation, 6 Rue Jules Horowitz, BP 181, F-38042 Grenoble CEDEX 9, France.) 15039586
HNRPK (3190) Ostrowski 2 Editing of hnRNP K protein mRNA in colorectal adenocarcinoma and surrounding mucosa.(Department of Gastroenterology, Medical Center for Postgraduate Education and Maria SkÅodowska-Curie Memorial Cancer Center and Institute of Oncology, ul. Roentgena 5, Warsaw 02-781, Poland.) 16404425,hnRNP K: one protein multiple processes.(Department of Medicine, University of Washington, Seattle, WA 98195, USA. ude.notgnihsaw.u|blorak#ude.notgnihsaw.u|blorak) 15170860
HNF4A (3172) Goldstein 2 The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter.(Human Metabolism Section, Laboratory of Pharmacology and Chemistry, National Institutes of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.) 15919766,Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha.(Laboratory of Pharmacology & Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.) 15933212
HNF4A (3172) Ryffel 2 HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma.(Institut für Zellbiologie (Tumorforschung), Universitätsklinikum Essen, D-45122 Essen, Germany.) 16007190,Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4alpha and HNF1beta in a pancreatic beta-cell line.(Institut für Zellbiologie (Tumorforschung), Universitätsklinikum Essen, D-45122 Essen, Germany.) 15520459
HNF4A (3172) Hadzopoulou-Cladaras 2 Distinct amino acid residues may be involved in coactivator and ligand interactions in hepatocyte nuclear factor-4alpha.(Department of Genetics, Development and Molecular Biology, Laboratory of Developmental Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece 54124.) 15826954,Critical role of residues defining the ligand binding pocket in hepatocyte nuclear factor-4alpha.(Aristotle University of Thessaloniki, Faculty of Sciences, School of Biology, Department of Genetics, Development and Molecular Biology, GR-54124, Thessaloniki, Greece.) 15123688
HNF4A (3172) Hansen 2 Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population.(Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, Gentofte, 2820, Copenhagen, Denmark. kd.onets|ahot#kd.onets|ahot) 15735891,Half of clinically defined maturity-onset diabetes of the young patients in Denmark do not have mutations in HNF4A, GCK, and TCF1.(Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, DK-2820 Gentofte, Denmark. kd.onets|ojda#kd.onets|ojda) 15928245
HNF4A (3172) Talianidis 2 Mitogen-activated protein kinase-mediated disruption of enhancer-promoter communication inhibits hepatocyte nuclear factor 4alpha expression.(Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Herakleion, Crete, Greece.) 16980607,Histone modifications defining active genes persist after transcriptional and mitotic inactivation.(Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Herakleion, Crete, Greece.) 15616580
TBX21 (30009) Weiss 2 T-bet polymorphisms are associated with asthma and airway hyperresponsiveness.(M.D.C.M., Channing Laboratory, Brigham and Women's Hospital, Boston, MA 02115, USA. ude.dravrah.gninnahc|ybar.nimajneb#ude.dravrah.gninnahc|ybar.nimajneb) 16179640,TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids.(Channing Laboratory and Pulmonary Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. ude.dravrah.gninnahc|arisitnat.nalek#ude.dravrah.gninnahc|arisitnat.nalek) 15604153
FOXR1 (283150) Katoh 2 Identification and characterization of human FOXN5 and rat Foxn5 genes in silico.(M&M Medical BioInformatics, Narashino 275-0022, Japan.) 15067358,Human FOX gene family (Review).(M&M Medical BioInformatics, Hongo 113-0033, Japan. pj.og.ccn|hotakm#pj.og.ccn|hotakm) 15492844
FOXP1 (27086) Banham 2 Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1alpha expression.(Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece. rg.tenhtrof.reh|grat#rg.tenhtrof.reh|grat) 16258506,Expression of the forkhead transcription factor FOXP1 is associated with estrogen receptor alpha and improved survival in primary human breast carcinomas.(Nuffield Department Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK. ku.ca.xo.slcdn|xof.nehpets#ku.ca.xo.slcdn|xof.nehpets) 15161711
GATA4 (2626) Heikinheimo 2 High GATA-4 expression associates with aggressive behavior, whereas low anti-Müllerian hormone expression associates with growth potential of ovarian granulosa cell tumors.(Program for Developmental and Reproductive Biology, Biomedicum Helsinki, University of Helsinki, P.O. Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland. if.iknisleh|nenottna.okkim#if.iknisleh|nenottna.okkim) 16159935,Transcription factors GATA-4 and GATA-6 in human adrenocortical tumors.(Children's Hospital, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.) 15666845
GATA3 (2625) Miyatake 2 Role of GATA-3 in IL-5 gene transcription by CD4+ T cells of asthmatic patients.(Department of Immunology, Tokyo Metropolitan Institute of Medical Science, Japan.) 15947486,GATA-3 suppresses IFN-gamma promoter activity independently of binding to cis-regulatory elements.(Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan.) 15251440
GABPA (2551) Kong 2 Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif.(Department of Pharmaceutics, Ernest-Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, USA.) 15917227,Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein.(Department of Pharmaceutics, Ernest-Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.) 15020583
NR5A1 (2516) Achermann 2 Analysis of DAX1 (NR0B1) and steroidogenic factor-1 (NR5A1) in children and adults with primary adrenal failure: ten years' experience.(UCL Institute of Child Health and Department of Medicine, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom.) 16684822,Steroidogenic factor-1 (SF-1) and its relevance to pediatric endocrinology.(UCL Institute of Child Health & Department of Medicine, University College London, UK.) 16816804
NR5A1 (2516) Miller 2 LBP proteins modulate SF1-independent expression of P450scc in human placental JEG-3 cells.(Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143-0978, USA.) 15471945,Regulation of cytochrome b5 gene transcription by Sp3, GATA-6, and steroidogenic factor 1 in human adrenal NCI-H295A cells.(Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143-0978, USA.) 15831526
NR5A1 (2516) Ogata 2 Association of cryptorchidism with Gly146Ala polymorphism in the gene for steroidogenic factor-1.(Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan.) 16500365,Association of severe micropenis with Gly146Ala polymorphism in the gene for steroidogenic factor-1.(Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo.) 16127213
NR5A2 (2494) Attia 2 The orphan nuclear receptor, liver receptor homolog-1, regulates cholesterol side-chain cleavage cytochrome p450 enzyme in human granulosa cells.(Division of Reproductive Endocrinology and Infertility, Cedars Medical Center, 1400 NW 12th Avenue, East Building 4th floor, Miami, Florida 33136, USA.) 15613430,Liver receptor homolog-1 regulates the expression of steroidogenic acute regulatory protein in human granulosa cells.(Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9032, USA.) 15181096
CIC (23152) Gygi 2 Large-scale characterization of HeLa cell nuclear phosphoproteins.(Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.) 15302935,Phosphoproteomic analysis of the developing mouse brain.(Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.) 15345747
FOXO1A (2308) Tindall 2 CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage.(Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.) 17038621,Androgens negatively regulate forkhead transcription factor FKHR (FOXO1) through a proteolytic mechanism in prostate cancer cells.(Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.) 14726521
FOXO1A (2308) Unterman 2 FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression.(Departments of Medicine and Physiology and Biophysics, University of Illinois College of Medicine, Chicago, IL 60612, USA.) 16492665,Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms.(Department of Medicine, University of Illinois at Chicago College of Medicine, and Medical Research Unit, Chicago, IL 60612, USA.) 14664696
FOXO1A (2308) Barr 2 Co-expression of alternatively spliced forms of PAX3, PAX7, PAX3-FKHR and PAX7-FKHR with distinct DNA binding and transactivation properties in rhabdomyosarcoma.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 15688409,Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.) 15184910
FOXM1 (2305) Costa 2 Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase.(Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine, 60607-7170, USA.) 16314512,Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators.(Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA.) 15024056
ATF5 (22809) Gu 2 ATF5 increases cisplatin-induced apoptosis through up-regulation of cyclin D3 transcription in HeLa cells.(State Key Laboratory of Genetic Engineering and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai 200032, People's Republic of China.) 16300731,Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity.(State Key Laboratory of Genetic Engineering and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai 200032, People's Republic of China.) 15358120
BPTF (2186) Jordan-Sciutto 2 Expression of the fetal Alz-50 clone 1 protein induces apoptotic cell death.(Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104-6030, USA.) 16137655,Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein.(Department of Pathology, University of Pennsylvania, 4010 Locust Street, Philadelphia, Pennsylvania 19104-6030, USA.) 15379550
ETV4 (2118) Shindoh 2 E1AF degradation by a ubiquitin-proteasome pathway.(Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, North 13 West 7, Kita-ku 060-8586, Sapporo, Japan.) 15629152,E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters.(Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, N13 W7, Kita-Ku, Sapporo 060-8586, Japan.) 15756447
ESRRA (2101) Giguère 2 A single nucleotide in an estrogen-related receptor alpha site can dictate mode of binding and peroxisome proliferator-activated receptor gamma coactivator 1alpha activation of target promoters.(Molecular Oncology Group, McGill University Health Centre, Montréal, Québec, Canada H3A 1A1.) 16150865,A polymorphic autoregulatory hormone response element in the human estrogen-related receptor alpha (ERRalpha) promoter dictates peroxisome proliferator-activated receptor gamma coactivator-1alpha control of ERRalpha expression.(Molecular Oncology Group, McGill University Health Center, Montréal, Québec H3A 1A1, Canada.) 14978033
EPAS1 (2034) Harris 2 The relation between hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression with anemia and outcome in surgically treated head and neck cancer.(Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.) 16826581,The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer.(Harold Hopkins Department of Urology, Royal Berkshire Hospital, Reading, UK.) 16278385
EPAS1 (2034) Peet 2 Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment.(School of Molecular and Biomedical Science, University of Adelaide, South Australia.) 16760477,Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulator.(School of Molecular and Biomedical Science and the Centre for the Molecular Genetics of Development, University of Adelaide, Adelaide, South Australia, 5005, Australia.) 15653678
ELK1 (2002) Liu 2 PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells.(Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.) 16297876,TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1.(The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha 410081, Hunan, People's Republic of China.) 15351693
ELK1 (2002) Reddy 2 A Phosphatidylinositol 3-kinase-regulated Akt-independent signaling promotes cigarette smoke-induced FRA-1 expression.(Department of Environmental Health Sciences, Bloomberg School of Public Health and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA.) 16490785,Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements.(Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA.) 15806162
ELF5 (2001) Sinha 2 Differentiation-specific transcriptional regulation of the ESE-2 gene by a novel keratinocyte-restricted factor.(Department of Biochemistry, State University of New York at Buffalo, Buffalo, New York 14214, USA.) 16229011,Determination of the consensus DNA-binding sequence and a transcriptional activation domain for ESE-2.(Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY 14214, USA.) 16704374
ELF4 (2000) Kai 2 Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein.(Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan.) 14976184,MEF up-regulates human beta-defensin 2 expression in epithelial cells.(Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.) 15013761
ELF4 (2000) Nimer 2 The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2.(Division of Hematologic Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 575, New York, NY 10021, USA.) 16581786,Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells.(Laboratory of Molecular Aspects of Hematopoiesis, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. gro.ccksm|ctavdeh#gro.ccksm|ctavdeh) 14625302
ELF3 (1999) Gutierrez-Hartmann 2 ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells.(Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA. gro.cma|pnidehcs#gro.cma|pnidehcs) 14767472,The ETS transcription factor ESE-1 transforms MCF-12A human mammary epithelial cells via a novel cytoplasmic mechanism.(Medical Scienctist Training Program, University of Colorado Health Sciences Center, Denver, CO 80262, USA. ude.cshcu|ttocserp.nosaj#ude.cshcu|ttocserp.nosaj) 15169914
ELF3 (1999) Oettgen 2 ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation.(Beth Israel Deaconess Medical Center, Department of Medicine, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA.) 14715662,Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86.(Cardiology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA.) 15075319
AHR (196) Safe 2 Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.(Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, College Station, Texas 77843-4466, USA.) 16675542,Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation.(Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, Veterinary Research Building 409, College Station, TX 77843-4466, USA.) 15026081
AHR (196) Perdew 2 ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription.(Center for Molecular Toxicology and Carcinogenesis and Department of Veterinary Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.) 15837795,Role of the aryl hydrocarbon receptor in drug metabolism.(The Pennsylvania State University, Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary Science, University Park, PA 16802, USA.) 16922649
EGR1 (1958) Eling 2 Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene.(Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.) 16079301,Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1.(Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.) 14662774
EGR1 (1958) Thiel 2 Specificity of transcriptional regulation by the zinc finger transcription factors Sp1, Sp3, and Egr-1.(Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, D-66421 Homburg, Germany.) 15523672,Transcriptional activation of the Egr-1 gene mediated by tetradecanoylphorbol acetate and extracellular signal-regulated protein kinase.(Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, D-66421 Homburg, Germany.) 15910736
EGR1 (1958) Tindall 2 Regulation of expression of the early growth response gene-1 (EGR-1) in malignant and benign cells of the prostate.(Department of Urology Research, Mayo Clinic, Rochester, Minnesota, USA.) 15486985,The cytoskeleton differentially localizes the early growth response gene-1 protein in cancer and benign cells of the prostate.(Department of Urology Research, Mayo Clinic, Rochester, MN 55905, USA.) 14985468
EGR1 (1958) Dahiya 2 Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer.(Department of Urology, University of California-San Francisco and Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA.) 15709168,Promoter CpG hypomethylation and transcription factor EGR1 hyperactivate heparanase expression in bladder cancer.(Department of Urology, Veterans Affairs Medical Center, San Francisco and University of California, San Francisco, 4150 Clement Street, CA 94121, USA.) 16007175
NR0B1 (190) Achermann 2 Analysis of DAX1 (NR0B1) and steroidogenic factor-1 (NR5A1) in children and adults with primary adrenal failure: ten years' experience.(UCL Institute of Child Health and Department of Medicine, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom.) 16684822,The role of SF1/DAX1 in adrenal and reproductive function.(Biochemistry, Endocrinology & Metabolism, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK. ku.ca.lcu.hci|nnamrehca.j#ku.ca.lcu.hci|nnamrehca.j) 15988384
E2F6 (1876) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
E2F4 (1874) Dynlacht 2 Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells.(Department of Pathology, MSB 504, New York University School of Medicine and New York University Cancer Institute, 550 First Avenue, New York, NY 10016, USA.) 16135806,A common set of gene regulatory networks links metabolism and growth inhibition.(Department of Pathology, MSB 504, New York University School of Medicine and New York University Cancer Institute, 550 First Avenue, New York, NY 10016, USA.) 15525513
E2F3 (1871) Ginsberg 2 Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F.(Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.) 15706352,Transcriptional regulation of AKT activation by E2F.(Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.) 15574337
E2F2 (1870) Ginsberg 2 Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F.(Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.) 15706352,Transcriptional regulation of AKT activation by E2F.(Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.) 15574337
ARID3A (1820) Webb 2 Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I.(Oklahoma Medical Research Foundation, Immunobiology and Cancer Research Program, 825 N. E. 13th Street, Oklahoma City, OK 73104, USA.) 16738337,The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations.(Department of Microbiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.) 15203319
DLX5 (1749) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
DLX3 (1747) Roberson 2 Smad6 represses Dlx3 transcriptional activity through inhibition of DNA binding.(Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA.) 16687405,A role for CCAAT/enhancer-binding protein beta in the basal regulation of the distal-less 3 gene promoter in placental cells.(Department of Biomedical Sciences, Cornell University College of Veterinary Medicine, Ithaca, New York 14853, USA.) 14670999
DDX5 (1655) Fuller-Pace 2 The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor.(Department of Molecular & Cellular Pathology, University of Dundee, Ninewells Hospital & Medical School, Dundee, UK.) 15660129,The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner.(Department of Molecular and Cellular Pathology, Ninewells Medical School, University of Dundee, DD1 9SY, UK. ac.lligcm.cnolom|nosliw.nairb#ac.lligcm.cnolom|nosliw.nairb) 15298701
CUTL1 (1523) Downward 2 CUTL1 is phosphorylated by protein kinase A, modulating its effects on cell proliferation and motility.(Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom.) 16574653,CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness.(Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom.) 15950902
NKX2-5 (1482) Borlak 2 Novel NKX2-5 mutations in diseased heart tissues of patients with cardiac malformations.(Department of Drug Research and Medical Biotechnology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany.) 15161646,Somatic NKX2-5 mutations as a novel mechanism of disease in complex congenital heart disease.(Drug Research and Medical Biotechnology, Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai-Fuchs-Strasse 1, D-30625 Hanover, Germany.) 15342699
ZFP90 (146198) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
FOXR2 (139628) Katoh 2 Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico.(M and M Medical BioInformatics, Narashino 275-0022, Japan.) 15202009,Identification and characterization of human FOXK1 gene in silico.(M&M Medical BioInformatics, Narashino 275-0022, Japan. pj.og.ccn|hotakm#pj.og.ccn|hotakm) 15202027
CREM (1390) Europe-Finner 2 Identification of human myometrial target genes of the cAMP pathway: the role of cAMP-response element binding (CREB) and modulator (CREMalpha and CREMtau2alpha) proteins.(School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle upon Tyne, UK. ku.ca.lcn|yeliab.dorraj#ku.ca.lcn|yeliab.dorraj) 15691874,The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM{alpha} (repressor) in human myometrial cells is mediated by SRp40.(School of Surgical and Reproductive Sciences, 3rd Floor, William Leech Building, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom. ku.ca.lcn|reppaC-nosyT.J.A#ku.ca.lcn|reppaC-nosyT.J.A) 16103121
CREB1 (1385) Montminy 2 Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues.(The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.) 15753290,The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.(Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.) 15454081
ZHX1 (11244) Wanker 2 A human protein-protein interaction network: a resource for annotating the proteome.(Max Delbrueck Center for Molecular Medicine, 13092 Berlin-Buch, Germany.) 16169070,A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.(Max-Delbrueck-Center for Molecular Medicine, 13125 Berlin-Buch, Germany.) 15383276
GMEB1 (10691) Nomura 2 Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury.(Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N12W6, Sapporo 060-0812, Japan.) 16497673,Regulation of procaspase-2 by glucocorticoid modulatory element-binding protein 1 through the interaction with caspase recruitment domain.(Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N12W6, Sapporo 060-0812, Japan.) 15555560
CEBPA (1050) Koeffler 2 Down-regulation and growth inhibitory role of C/EBPalpha in breast cancer.(Division of Hematology/Oncology, Cedars-Sinai Medical Center, University of California at Los Angeles School of Medicine, USA. gro.shsc|syreg#gro.shsc|syreg) 15867211,Protein partners of C/EBPepsilon.(Division of Hematology/Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, Calif. 90048, USA.) 15588942
HOXB13 (10481) Jeng 2 HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4.(Department of Urology, Walther Oncology Center, Indiana University, Indianapolis, Indiana 46202, USA. ude.iupui|gnujhc#ude.iupui|gnujhc) 15126340,HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling.(Department of Urology, Walther Oncology Center, Indiana University, Indianapolis, Indiana, USA.) 15604291
CDX2 (1045) Freund 2 Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.(Development and Physiopathology of the Intestine and Pancreas, 3, avenue Molière, 67200 Strasbourg, France.) 16027724,Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression.(Department of Pathology, University of Erlangen-Nürnberg, Erlangen, Germany. ed.negnalre-inu.demi.ohtap|ztelbarb.samoht#ed.negnalre-inu.demi.ohtap|ztelbarb.samoht) 15466189
CDX2 (1045) Tatematsu 2 Expression of the intestine-specific transcription factors, Cdx1 and Cdx2, correlates shift to an intestinal phenotype in gastric cancer cells.(Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, 464-8681 Nagoya, Japan.) 14615935,Cdx2 expression in pancreatic tumors: Relationship with prognosis of invasive ductal carcinomas.(Division of Oncological Pathology, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.) 15547744
CDX2 (1045) Waldman 2 Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cells.(Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.) 16618413,The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomas.(Division of Clinical Pharmacology, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA.) 16361536
CDX1 (1044) Bodmer 2 CDX1 is an important molecular mediator of Barrett's metaplasia.(Cancer Research UK Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.) 15894614,Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines.(Cancer Research UK Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom.) 14704280
TOPORS (10210) Kobarg 2 Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins.(Centro de Biologia Molecular Estrutural, Laboratório Nacional de Luz Síncrotron, Rua Giuseppe Máximo Scolfaro 10.000, C.P. 6192, 13084-971 Campinas, SP, Brazil.) 16455055,CGI-55 interacts with nuclear proteins and co-localizes to p80-coilin positive-coiled bodies in the nucleus.(Centro de Biologia Molecular Estrutural, Laboratório Nacional de Luz Síncrotron, Campinas, SP, Brazil.) 16679534
TOPORS (10210) Rubin 2 The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor.(Department of Pharmacology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA.) 15107820,Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.(Department of Pharmacology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08901, USA.) 15247280
ZBTB33 (10009) Daniel 2 The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin.(Department of Biology, LSB-331, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1.) 15817151,Nuclear import of the BTB/POZ transcriptional regulator Kaiso.(Department of Biology, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.) 15564377
NR2E3 (10002) Swaroop 2 Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors.(Neuroscience Graduate Program, Department of Opthalmology and Visual Sciences, University of Michigan, Ann Arbor 48105, USA.) 15190009,Mutation analysis of NR2E3 and NRL genes in Enhanced S Cone Syndrome.(MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom. ku.crm.ugh|thgirw.nala#ku.crm.ugh|thgirw.nala) 15459973
FOXL2 (668) De Baere 2
FOXL2 (668) Veitia 2 Deletions in the polyAlanine-containing transcription factor FOXL2 lead to intranuclear aggregation.(INSERM U709 Génomique et Epigénétique des Pathologies Placentaires and Universités Paris V & VII, Paris 75014, France.) 16219626,A recurrent polyalanine expansion in the transcription factor FOXL2 induces extensive nuclear and cytoplasmic protein aggregation.(INSERM E0021 Génomique fonctionnelle du Développement, Hôpital Cochin, 123 bd du Port Royal, Bâtiment Baudelocque, 75014 Paris, France.) 15591279
SNAI1 (6615) García de Herreros 2
PPARG (5468) 4
PPARG (5468) Palmer 3 Both PPARgamma and PPARdelta influence sulindac sulfide-mediated p21WAF1/CIP1 upregulation in a human prostate epithelial cell line.(Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.) 16091736,Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes.(Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.) 14730381,Cardiovascular risk in type 2 diabetes is associated with variation at the PPARG locus: a Go-DARTS study.(Institute for Cardiovascular Research, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, Scotland.) 15486307
PPARG (5468) Laakso 2 Common polymorphisms in the PPARgamma2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men.(Department of Public Health Science and General Practice, University of Oulu, Aapistie 1, P.O. Box 5000, Oulu 90014, Finland. if.uluo.tneduts|ivasuomf#if.uluo.tneduts|ivasuomf) 15781195,Effect of the Pro12Ala polymorphism of the PPARg2 gene on serum adiponectin changes.(Department of Public Health Science and General Practice, University of Oulu, Finland. if.uluo.tneduts|ivasuomf#if.uluo.tneduts|ivasuomf) 16230789
PPARG (5468) Seo 2 Identification of a truncated alternative splicing variant of human PPARgamma1 that exhibits dominant negative activity.(Department of Pharmacology, Gyeongsang Institute of Health Science, College of Medicine, National University, Jinju, Republic of Korea.) 16842753,Phorbol ester potentiates the growth inhibitory effects of troglitazone via up-regulation of PPARgamma in A549 cells.(Department of Pharmacology, Gyeongsang Institute of Health Science, College of Medicine, Gyeongsang National University, Jinju 660-751, Republic of Korea.) 16945329
PPARG (5468) Chen 2 Polymorphisms of the peroxisome proliferator-activated receptor-gamma and its coactivator-1alpha genes in Chinese women with polycystic ovary syndrome.(Human Genetic Identification Laboratory, Medical School of Nanjing University, Nanjing, China.) 16600233,The effect of high glucose and PPAR-gamma agonists on PPAR-gamma expression and function in HK-2 cells.(Department of Medicine, The University of Sydney, Renal Research Group, Kolling Institute of Medical Research, Royal North Shore Hospital, New South Wales 2065, Australia.) 15113752
PPARG (5468) Ferrell 2 The C161-->T polymorphism in peroxisome proliferator-activated receptor gamma, but not P12A, is associated with insulin resistance in Hispanic and non-Hispanic white women: evidence for another functional variant in peroxisome proliferator-activated receptor gamma.(Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. ude.ttip.negh|tteffom.nasus#ude.ttip.negh|tteffom.nasus) 16253648,Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and body composition in males.(Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.) 15015141
PPARG (5468) Jiang 2 The conserved residue Phe273(282) of PPARalpha(gamma), beyond the ligand-binding site, functions in binding affinity through solvation effect.(Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, China.) 15935279,The localisation and reduction of nuclear staining of PPARgamma and PGC-1 in human breast cancer.(Metastasis and Angiogenesis Research Group, University Deptartment of Surgery, University of Wales College of Medicine, Cardiff, CF14 4XN, UK. ku.ca.fc|lgsniktaw#ku.ca.fc|lgsniktaw) 15254719
PPARG (5468) Southgate 2 Role of PPARgamma and EGFR signalling in the urothelial terminal differentiation programme.(Jack Birch Unit of Molecular Carcinogenesis, Department of Biology, University of York YO10 5YW, UK.) 15054105,Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells.(Department of Biology, Jack Birch Unit of Molecular Carcinogenesis, University of York, York, United Kingdom.) 15111325
PPARG (5468) Arslan 2 Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma gene in women with polycystic ovary syndrome.(Kirikkale University Faculty of Medicine, Department of Endocrinology and Metabolism, Kirikkale, Turkey. moc.liamtoh|ttrarum#moc.liamtoh|ttrarum) 16785159,Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma gene in first-degree relatives of subjects with polycystic ovary syndrome.(Department of Endocrinology and Metabolism, Faculty of Medicine, Kirikkale University, Turkey. moc.liamtoh|ttrarum#moc.liamtoh|ttrarum) 16316841
PPARG (5468) Karpe 2 The in vivo effects of the Pro12Ala PPARgamma2 polymorphism on adipose tissue NEFA metabolism: the first use of the Oxford Biobank.(Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford OX3 7LJ, UK. ku.ca.xo.pilxo|nat.yrrag#ku.ca.xo.pilxo|nat.yrrag) 16362285,Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma.(Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, OX3 7LJ, UK. ku.ca.xo.pilxo|suresir.flu#ku.ca.xo.pilxo|suresir.flu) 15855323
NR4A2 (4929) 2
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