TF Author AHR To NR1I2
Gene ID Last Name Gene2PubmedReferences (2003 or more recent) Gene2Pubmed Links
AHR (196) Perdew 2 ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription.(Center for Molecular Toxicology and Carcinogenesis and Department of Veterinary Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.) 15837795,Role of the aryl hydrocarbon receptor in drug metabolism.(The Pennsylvania State University, Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary Science, University Park, PA 16802, USA.) 16922649
AHR (196) Safe 2 Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.(Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, College Station, Texas 77843-4466, USA.) 16675542,Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation.(Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, Veterinary Research Building 409, College Station, TX 77843-4466, USA.) 15026081
AHRR (57491) Ogata 2 Association of micropenis with Pro185Ala polymorphism of the gene for aryl hydrocarbon receptor repressor involved in dioxin signaling.(Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan.) 15758562,Association of male infertility with Pro185Ala polymorphism in the aryl hydrocarbon receptor repressor gene: implication for the susceptibility to dioxins.(Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan.) 15474075
AHRR (57491) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
AIRE (326) Matsumoto 2 AIRE functions as an E3 ubiquitin ligase.(Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.) 14734522,Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner.(Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima, Tokushima 770-8503, Japan.) 15150263
AIRE (326) Peterson 3 Ets transcription factors regulate AIRE gene promoter.(Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland. if.atu|umsatl#if.atu|umsatl) 16890195,Cooperative activation of transcription by autoimmune regulator AIRE and CBP.(Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland.) 15964547,Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage.(Department of Pathology, Institute of Medical Technology, Tampere University Hospital, University of Tampere, Finnmedi-1, Biokatu 6, Tampere 33014, Finland. if.tut.sc|nnallis#if.tut.sc|nnallis) 15482854
AR (367) Bhasin 2 Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men.(Division of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.) 15522925,Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment.(Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA.) 15472231
AR (367) Chang 5 Androgen receptor (AR) NH2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growth.(The George H. Whipple Laboratory for Cancer Research, Department of Pathology, and the Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA.) 15514032,Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells.(George H. Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA.) 14966297,Regulation of interleukin-6-mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells.(George H. Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, New York 14642, USA.) 15129430
AR (367) Foresta 2 Androgen receptor gene CAG and GGC repeat lengths in cryptorchidism.(University of Padova, Department of Histology, Microbiology, and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, 35121 Padova, Italy.) 15757859,Androgen receptor gene CAG and GGC repeat lengths in idiopathic male infertility.(University of Padova, Department of Medical and Surgical Sciences, Centre for Male Gamete Cryopreservation, Padova, Italy.) 15044606
AR (367) Giwercman 4 Androgen receptor gene GGN repeat length and reproductive characteristics in young Swedish men.(Molecular Reproductive Medicine Research Unit, Department of Clinical Sciences, Lund University, Fertility Centre, Malmö University Hospital, SE-205 02 Malmö, Sweden.) 16868150,A novel mutation in the D-box of the androgen receptor gene (S597R) in two unrelated individuals Is associated with both normal phenotype and severe PAIS.(Department of Urology, Malmö University Hospital, Lund University, Malmö, Sweden. es.ul.sam.rik|namcrewiG.ennovY#es.ul.sam.rik|namcrewiG.ennovY) 14646391,Androgen receptor gene GGN and CAG polymorphisms among severely oligozoospermic and azoospermic Swedish men.(Fertility Centre, Scanian Andrology Centre, Malmö, Sweden. es.ul.sam.rik|leyahur.risay#es.ul.sam.rik|leyahur.risay) 15229204
AR (367) Hughes 2 Five novel androgen receptor gene mutations associated with complete androgen insensitivity syndrome.(Department of Paediatrics, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom. if.uku|nenialeksaaj.omraj#if.uku|nenialeksaaj.omraj) 16470553,Human androgen receptor gene ligand-binding-domain mutations leading to disrupted interaction between the N- and C-terminal domains.(University Department of Paediatrics, Addenbrooke's Hospital, University of Cambridge, Hills Road CB2 2QQ, UK.) 16595706
AR (367) Isaacs 2 PC3, but not DU145, human prostate cancer cells retain the coregulators required for tumor suppressor ability of androgen receptor.(Chemical Therapeutics Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.) 16835890,Molecular characterization of the commonly used human androgen receptor expression vector, pSG5-AR.(The Sidney Kimmel Comprehensive Cancer Center, the Graduate Training Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.) 14968432
AR (367) Knudsen 4 Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation.(Department of Cell Biology, University of Cincinnati, Cincinnati, OH 45267, USA.) 16461912,Cyclin D1 binding to the androgen receptor (AR) NH2-terminal domain inhibits activation function 2 association and reveals dual roles for AR corepression.(Department of Cell Biology, University of Cincinnati College of Medicine, P.O. Box 670521, 3125 Eden Avenue, Cincinnati, Ohio 45267-0521, USA.) 15539430,A central domain of cyclin D1 mediates nuclear receptor corepressor activity.(Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0521, USA.) 15558026
AR (367) Tsai 2 Association study of androgen receptor CAG repeat polymorphism and male violent criminal activity.(Department of Psychiatry, General Psychiatry Section, Taipei Veterans General Hospital, No. 201 Shih-Pai Road Sec. 2, Taipei 11217, Taiwan, ROC.) 16377095,The E3 ubiquitin ligase CHIP binds the androgen receptor in a phosphorylation-dependent manner.(Program in Structural and Computational Biology and Molecular Biophysics, One Baylor Plaza, Baylor College of Medicine, Houston, TX 77030, USA.) 16725394
AR (367) Wilson 3 Probing the functional link between androgen receptor coactivator and ligand-binding sites in prostate cancer and androgen insensitivity.(Laboratory for Reproductive Biology, Lineberger Comprehensive Cancer Center, Department of Pediatrics, Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.) 16365032,Epidermal growth factor increases coactivation of the androgen receptor in recurrent prostate cancer.(Laboratories for Reproductive Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599-7500, USA.) 14662770,An androgen receptor NH2-terminal conserved motif interacts with the COOH terminus of the Hsp70-interacting protein (CHIP).(Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.) 15107424
AR (367) Zajac 3 Novel androgen receptor gene mutations in Australian patients with complete androgen insensitivity syndrome.(Department of Medicine (AH/NH), University of Melbourne, Austin Health, Heidelberg, VIC 3084, Australia. ua.ude.bleminu|naelcamh#ua.ude.bleminu|naelcamh) 14974091,Polymorphic CAG repeat length in the androgen receptor gene and association with neurodegeneration in a heterozygous female carrier of Kennedy's disease.(Centre for Hormone Research, Murdoch Childrens Research Institute, University of Melbourne Royal Children's Hospital, Flemington Road, Parkville, Melbourne, Victoria 3052, Australia.) 14999487,Increased frequency of long androgen receptor CAG repeats in male breast cancers.(Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, VIC, 3084, Australia. ua.ude.bleminu|naelcamh#ua.ude.bleminu|naelcamh) 15609126
ARID3A (1820) Webb 2 Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I.(Oklahoma Medical Research Foundation, Immunobiology and Cancer Research Program, 825 N. E. 13th Street, Oklahoma City, OK 73104, USA.) 16738337,The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations.(Department of Microbiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.) 15203319
ARNT (405) Whitelaw 3 Novel DNA binding by a basic helix-loop-helix protein. The role of the dioxin receptor PAS domain.(School of Molecular and Biomedical Science (Biochemistry), University of Adelaide, South Australia, Australia. ua.ude.edialeda|htimsnampahc.enna#ua.ude.edialeda|htimsnampahc.enna) 16520375,Phosphorylation inhibits DNA-binding of alternatively spliced aryl hydrocarbon receptor nuclear translocator.(School of Molecular and Biomedical Science (Biochemistry), Centre for the Molecular Genetics of Development, University of Adelaide, SA 5005, Australia. ua.ude.usc|yelwekr#ua.ude.usc|yelwekr) 16129408,Contribution of the Per/Arnt/Sim (PAS) domains to DNA binding by the basic helix-loop-helix PAS transcriptional regulators.(School of Molecular and Biomedical Science (Biochemistry), University of Adelaide, South Australia, Australia. ua.ude.edialeda|htimsnampahc.enna#ua.ude.edialeda|htimsnampahc.enna) 14638687
ATF3 (467) Baek 2 Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner.(Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.) 16286461,Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner.(Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.) 15670751
ATF3 (467) Kilberg 2 Interaction of RNA-binding proteins HuR and AUF1 with the human ATF3 mRNA 3'-untranslated region regulates its amino acid limitation-induced stabilization.(Department of Biochemistry and Molecular Biology, Genetics Institute, and Shands Cancer Center, University of Florida College of Medicine, Gainesville, Florida 32610, USA.) 16109718,Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone acetylation.(Department of Biochemistry and Molecular Biology, Genetics Institute, and Shands Cancer Center, University of Florida College of Medicine, Gainesville, Florida 32610, USA.) 15385533
ATF3 (467) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
ATF4 (468) Abcouwer 2 The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism.(Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131-0001, USA.) 15788408,Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4.(Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131-0001, USA.) 14747470
ATF5 (22809) Gu 2 ATF5 increases cisplatin-induced apoptosis through up-regulation of cyclin D3 transcription in HeLa cells.(State Key Laboratory of Genetic Engineering and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai 200032, People's Republic of China.) 16300731,Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity.(State Key Laboratory of Genetic Engineering and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai 200032, People's Republic of China.) 15358120
BACH1 (571) Bonkovsky 2 HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells.(Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-1111, USA.) 16530877,Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS.(Department of Medicine and Pharmacology, the General Clinical Research Center of the University of Connecticut Health Center, Farmington, Connecticut 06030, USA. ude.chcu|nahS#ude.chcu|nahS) 15465821
BACH1 (571) Taketani 2 Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells.(Department of Biotechnology, Kyoto Institute of Technology, Kyoto 606-8585, Japan.) 14660636,Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells.(Department of Biotechnology, Kyoto Institute of Technology, Kyoto 606-8585, Japan.) 15464985
BCL6 (604) Melnick 2 ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein.(Department of Medicine, Mount Sinai School of Medicine, One Gustave Levy Pl, New York, NY 10029, USA.) 14551142,Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.(Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.) 15531890
BPTF (2186) Jordan-Sciutto 2 Expression of the fetal Alz-50 clone 1 protein induces apoptotic cell death.(Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104-6030, USA.) 16137655,Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein.(Department of Pathology, University of Pennsylvania, 4010 Locust Street, Philadelphia, Pennsylvania 19104-6030, USA.) 15379550
CDKN2A (1029) 3
CDKN2A (1029) Bianchi-Scarrà 2 INK4/ARF germline alterations in pancreatic cancer patients.(Dipartimento di Oncologia, Biologia e Genetica (DOBiG), Università degli Studi di Genova, Genova, Italy.) 14679123,Inverse correlation between p16INK4A expression and NF-kappaB activation in melanoma progression.(Department of Oncology, Biology and Genetics, University of Genova, Italy.) 15297971
CDKN2A (1029) Blin 2 Inactivation of the cyclin-dependent kinase inhibitor 2A (CDKN2A) gene in squamous cell carcinoma of the larynx.(Department of Pathophysiology, Wroclaw Medical University, Poland.) 14991744,Impairment of MLH1 and CDKN2A in oncogenesis of laryngeal cancer.(Department of Genetics, Medical University, ul. Marcinkowskiego 1, Wroclaw 50-368, Poland. lp.corw.ma.neg|kedaisas#lp.corw.ma.neg|kedaisas) 15083191
CDKN2A (1029) Daniel 2 p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity.(Department of Hematology, Oncology and Tumor Immunology, University Medical Center Charité, Campus Berlin-Buch, D-13125 Berlin-Buch, Germany.) 15582998,Loss of p21 disrupts p14 ARF-induced G1 cell cycle arrest but augments p14 ARF-induced apoptosis in human carcinoma cells.(Department of Hematology, Oncology and Tumor Immunology, University Medical Center Charité, Campus Berlin-Buch, Berlin-Buch, Germany.) 15750619
CDKN2A (1029) Gazzeri 3 p14ARF promotes RB accumulation through inhibition of its Tip60-dependent acetylation.(INSERM U578, Groupe de Recherche sur le Cancer du Poumon, Université Joseph Fourier, Faculté de Medecine, Institut Albert Bonniot, La Tronche Cedex, France.) 16501607,p14ARF triggers G2 arrest through ERK-mediated Cdc25C phosphorylation, ubiquitination and proteasomal degradation.(INSERM U578, Groupe de Recherche sur le Cancer du Poumon, Université Joseph Fourier, La Tronche, France. rf.elbonerg-fju|nimyE.ecirtaeB#rf.elbonerg-fju|nimyE.ecirtaeB) 16582626,p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress.(Groupe de Recherche sur le Cancer du Poumon, INSERM U578, Institut Albert Bonniot, 38706 La Tronche Cedex, France.) 16705183
CDKN2A (1029) Halloran 2 Increased expression of senescence-associated cell cycle inhibitor p16INK4a in deteriorating renal transplants and diseased native kidney.(Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, Canada. ed.grebldieh-inu.dem|klem.ettena#ed.grebldieh-inu.dem|klem.ettena) 15888044,Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney.(Division of Nephrology and Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. ed.oohay|klemettenna#ed.oohay|klemettenna) 14717921
CDKN2A (1029) Kim 4 Methylation of p16(INK4A) and p57(KIP2) are involved in the development and progression of gastric MALT lymphomas.(Department of Clinical Pathology, The Catholic University of Korea, College of Medicine, Inchon, Korea.) 16357845,The hypermethylation and protein expression of p16 INK4A and DNA repair gene O6-methylguanine-DNA methyltransferase in various uterine cervical lesions.(Department of Pathology, Korea University College of Medicine, Seoul, South Korea.) 15785933,Human papillomavirus genotyping by oligonucleotide microarray and p16 expression in uterine cervical intraepithelial neoplasm and in invasive carcinoma in Korean women.(Department of Pathology, Yanbian University College of Medicine, Yanji, China.) 15998377
CDKN2A (1029) Leachman 2 Nevus distribution in a Utah melanoma kindred with a temperature-sensitive CDKN2A mutation.() 16354203,Longitudinal assessment of the nevus phenotype in a melanoma kindred.(The Melanoma Program, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112-5550, USA.) 15304099
CDKN2A (1029) Li 3 Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma.(Department of Oncology, Second Hospital, Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China. nc.moc.oohay|ilambhm#nc.moc.oohay|ilambhm) 15655836,p53 activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF.(Radiation Biology, Division of Radiation Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA.) 14729628,Methylation of p16 CpG islands associated with malignant transformation of gastric dysplasia in a population-based study.(Peking University School of Oncology and Beijing Institute for Cancer Research, Beijing, People's Republic of China.) 15297411
CDKN2A (1029) Tong 2 Sp1 is involved in the transcriptional activation of p16(INK4) by p21(Waf1) in HeLa cells.(Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, 38 Xueyuan Road, Beijing 100083, PR China.) 15094066,Regulation of cellular senescence and p16(INK4a) expression by Id1 and E47 proteins in human diploid fibroblast.(Department of Biochemistry and Molecular Biology, Peking University, Health Science Center, 38 Xueyuan Road, Beijing 100083, People's Republic of China.) 15138269
CDX1 (1044) Bodmer 2 CDX1 is an important molecular mediator of Barrett's metaplasia.(Cancer Research UK Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.) 15894614,Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines.(Cancer Research UK Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom.) 14704280
CDX2 (1045) Freund 2 Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.(Development and Physiopathology of the Intestine and Pancreas, 3, avenue Molière, 67200 Strasbourg, France.) 16027724,Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression.(Department of Pathology, University of Erlangen-Nürnberg, Erlangen, Germany. ed.negnalre-inu.demi.ohtap|ztelbarb.samoht#ed.negnalre-inu.demi.ohtap|ztelbarb.samoht) 15466189
CDX2 (1045) Tatematsu 2 Expression of the intestine-specific transcription factors, Cdx1 and Cdx2, correlates shift to an intestinal phenotype in gastric cancer cells.(Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, 464-8681 Nagoya, Japan.) 14615935,Cdx2 expression in pancreatic tumors: Relationship with prognosis of invasive ductal carcinomas.(Division of Oncological Pathology, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.) 15547744
CDX2 (1045) Waldman 2 Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cells.(Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.) 16618413,The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomas.(Division of Clinical Pharmacology, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA.) 16361536
CEBPA (1050) Koeffler 2 Down-regulation and growth inhibitory role of C/EBPalpha in breast cancer.(Division of Hematology/Oncology, Cedars-Sinai Medical Center, University of California at Los Angeles School of Medicine, USA. gro.shsc|syreg#gro.shsc|syreg) 15867211,Protein partners of C/EBPepsilon.(Division of Hematology/Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, Calif. 90048, USA.) 15588942
CEBPB (1051) Amini 2 Cooperativity between Rad51 and C/EBP family transcription factors modulates basal and Tat-induced activation of the HIV-1 LTR in astrocytes.(Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA.) 16511829,Cooperative interaction of C/EBP beta and Tat modulates MCP-1 gene transcription in astrocytes.(Center for Neurovirology and Cancer Biology, Temple University, 1900 North 12th Street, 015-96, Room 203, Philadelphia, PA 19122, USA.) 15710476
CEBPB (1051) Kalvakolanu 3 A role for mixed lineage kinases in regulating transcription factor CCAAT/enhancer-binding protein-{beta}-dependent gene expression in response to interferon-{gamma}.(Greenebaum Cancer Center, Department of Microbiology and Immunology, University of Maryland School of Medicine, Balltimore, MD 21201, USA.) 15878863,IFN-gamma-stimulated transcriptional activation by IFN-gamma-activated transcriptional element-binding factor 1 occurs via an inducible interaction with CAAAT/enhancer-binding protein-beta.(Greenebaum Cancer Center, Department of Microbiology and Immunology, Molecular and Cellular Biology Graduate Program, University of Maryland School of Medicine, Baltimore, MD 21201, USA.) 15879117,Development of monoclonal antibodies against GBF1 and their use in studying its functions.(Greenebaum Cancer Center, Department of Microbiology and Immunology, 655 W. Baltimore Street, University of Maryland School of Medicine, Baltimore, MD 21201, USA.) 16318580
CEBPB (1051) Kilberg 3 Amino-acid limitation induces transcription from the human C/EBPbeta gene via an enhancer activity located downstream of the protein coding sequence.(Department of Biochemistry and Molecular Biology, Genetics Institute, and Shands Cancer Center, University of Florida College of Medicine, Gainesville, FL 32610, USA.) 16026328,Human CCAAT/enhancer-binding protein beta gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence.(Department of Biochemistry and Molecular Biology, Center for Mammalian Genetics, and Center for Nutritional Sciences, University of Florida College of Medicine, Gainesville, FL 32610-0245, USA.) 15102854,Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone acetylation.(Department of Biochemistry and Molecular Biology, Genetics Institute, and Shands Cancer Center, University of Florida College of Medicine, Gainesville, Florida 32610, USA.) 15385533
CEBPD (1052) Chang 2 Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene.(Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.) 16397300,Induction of human NF-IL6beta by epidermal growth factor is mediated through the p38 signaling pathway and cAMP response element-binding protein activation in A431 cells.(Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.) 15901830
CEBPD (1052) DeWille 4 Promoter methylation reduces C/EBPdelta (CEBPD) gene expression in the SUM-52PE human breast cancer cell line and in primary breast tumors.(Department of Veterinary Biosciences and Ohio State Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.) 16322893,C/EBPdelta is a downstream mediator of IL-6 induced growth inhibition of prostate cancer cells.(Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.) 15486993,CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control.(Department of Veterinary Biosciences and Division of Molecular Biology and Cancer Genetics, Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.) 15389878
CEBPD (1052) Koeffler 2 C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation.(Cedars-Sinai Medical Center, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, CA 90048, USA. gro.shsc|syreg#gro.shsc|syreg) 15674331,Protein partners of C/EBPepsilon.(Division of Hematology/Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, Calif. 90048, USA.) 15588942
CEBPE (1053) Koeffler 3 C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis.(Cedars-Sinai Medical Center, Davis Bldg 5066, 8700 Beverly Blvd, Los Angeles, CA 90048, USA. gro.shsc|syreg#gro.shsc|syreg) 12947005,Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes.(Division of Hematology/Oncology, Cedars-Sinai Medical Center, University of California at Los Angeles, CA 90048, USA. gro.shsc|syreg#gro.shsc|syreg) 15308577,Protein partners of C/EBPepsilon.(Division of Hematology/Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, Calif. 90048, USA.) 15588942
CHX10 (338917) Bremner 2 CHX10 targets a subset of photoreceptor genes.(Toronto Western Research Institute, University Health Network, Ontario, Canada.) 16236706,Transcriptional activity of the paired-like homeodomain proteins CHX10 and VSX1.(Toronto Western Research Institute, University Health Network Program, University of Toronto, Toronto, Ontario M5T 2S8, Canada.) 15647262
CIC (23152) Gygi 2 Large-scale characterization of HeLa cell nuclear phosphoproteins.(Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.) 15302935,Phosphoproteomic analysis of the developing mouse brain.(Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.) 15345747
CREB1 (1385) Montminy 2 Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues.(The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.) 15753290,The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.(Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.) 15454081
CREM (1390) Europe-Finner 2 Identification of human myometrial target genes of the cAMP pathway: the role of cAMP-response element binding (CREB) and modulator (CREMalpha and CREMtau2alpha) proteins.(School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle upon Tyne, UK. ku.ca.lcn|yeliab.dorraj#ku.ca.lcn|yeliab.dorraj) 15691874,The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM{alpha} (repressor) in human myometrial cells is mediated by SRp40.(School of Surgical and Reproductive Sciences, 3rd Floor, William Leech Building, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom. ku.ca.lcn|reppaC-nosyT.J.A#ku.ca.lcn|reppaC-nosyT.J.A) 16103121
CUTL1 (1523) Downward 2 CUTL1 is phosphorylated by protein kinase A, modulating its effects on cell proliferation and motility.(Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom.) 16574653,CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness.(Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom.) 15950902
DDX5 (1655) Fuller-Pace 2 The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor.(Department of Molecular & Cellular Pathology, University of Dundee, Ninewells Hospital & Medical School, Dundee, UK.) 15660129,The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner.(Department of Molecular and Cellular Pathology, Ninewells Medical School, University of Dundee, DD1 9SY, UK. ac.lligcm.cnolom|nosliw.nairb#ac.lligcm.cnolom|nosliw.nairb) 15298701
DLX3 (1747) Roberson 2 Smad6 represses Dlx3 transcriptional activity through inhibition of DNA binding.(Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA.) 16687405,A role for CCAAT/enhancer-binding protein beta in the basal regulation of the distal-less 3 gene promoter in placental cells.(Department of Biomedical Sciences, Cornell University College of Veterinary Medicine, Ithaca, New York 14853, USA.) 14670999
DLX5 (1749) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
E2F1 (1869) Chen 3 Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage.(Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.) 16892051,Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism.(Molecular Oncology Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 33612, USA.) 15713665,ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance.(Department of Biological Chemistry, School of Medicine, UCD Cancer Center/Basic Science, University of California at Davis, Sacramento, CA 95817, USA.) 15169882
E2F1 (1869) Ginsberg 2 Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F.(Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.) 15706352,Transcriptional regulation of AKT activation by E2F.(Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.) 15574337
E2F1 (1869) Johnson 2 Oncogenes and the DNA damage response: Myc and E2F1 engage the ATM signaling pathway to activate p53 and induce apoptosis.(The University of Texas MD Anderson Cancer Center, Science Park Research Division, Department of Carcinogenesis, Smithville, Texas, USA.) 16582589,E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis.(Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, USA.) 15140942
E2F1 (1869) Kelley 2 Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis.(Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA.) 14681231,IL-1beta suppresses prolonged Akt activation and expression of E2F-1 and cyclin A in breast cancer cells.(Laboratory of Immunophysiology, University of Illinois, Urbana, IL 61801, USA.) 15187102
E2F1 (1869) Koeffler 2 C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation.(Cedars-Sinai Medical Center, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, CA 90048, USA. gro.shsc|syreg#gro.shsc|syreg) 15674331,C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis.(Cedars-Sinai Medical Center, Davis Bldg 5066, 8700 Beverly Blvd, Los Angeles, CA 90048, USA. gro.shsc|syreg#gro.shsc|syreg) 12947005
E2F1 (1869) Kowalik 3 Rb inactivation leads to E2F1-mediated DNA double-strand break accumulation.(Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, UMass Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655, USA.) 16186801,E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts.(Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, 01655, USA.) 16434972,Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2.(Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.) 15024084
E2F1 (1869) Lu 2 ASPP1 and ASPP2 are new transcriptional targets of E2F.(Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK.) 15731768,Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315.(Ludwig Institute for Cancer Research, University College London Branch, London, UK.) 16037820
E2F1 (1869) Zhang 2 Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway.(Department of Pharmacology and Toxicology and Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.) 16170383,Novel MDM2 p53-independent functions identified through RNA silencing technologies.(Department of Pharmacology and Toxicology and Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.) 16394138
E2F2 (1870) Ginsberg 2 Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F.(Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.) 15706352,Transcriptional regulation of AKT activation by E2F.(Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.) 15574337
E2F3 (1871) Ginsberg 2 Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F.(Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.) 15706352,Transcriptional regulation of AKT activation by E2F.(Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.) 15574337
E2F4 (1874) Dynlacht 2 Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells.(Department of Pathology, MSB 504, New York University School of Medicine and New York University Cancer Institute, 550 First Avenue, New York, NY 10016, USA.) 16135806,A common set of gene regulatory networks links metabolism and growth inhibition.(Department of Pathology, MSB 504, New York University School of Medicine and New York University Cancer Institute, 550 First Avenue, New York, NY 10016, USA.) 15525513
E2F6 (1876) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
EGR1 (1958) Dahiya 2 Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer.(Department of Urology, University of California-San Francisco and Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA.) 15709168,Promoter CpG hypomethylation and transcription factor EGR1 hyperactivate heparanase expression in bladder cancer.(Department of Urology, Veterans Affairs Medical Center, San Francisco and University of California, San Francisco, 4150 Clement Street, CA 94121, USA.) 16007175
EGR1 (1958) Eling 2 Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene.(Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.) 16079301,Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1.(Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.) 14662774
EGR1 (1958) Thiel 2 Specificity of transcriptional regulation by the zinc finger transcription factors Sp1, Sp3, and Egr-1.(Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, D-66421 Homburg, Germany.) 15523672,Transcriptional activation of the Egr-1 gene mediated by tetradecanoylphorbol acetate and extracellular signal-regulated protein kinase.(Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, D-66421 Homburg, Germany.) 15910736
EGR1 (1958) Tindall 2 Regulation of expression of the early growth response gene-1 (EGR-1) in malignant and benign cells of the prostate.(Department of Urology Research, Mayo Clinic, Rochester, Minnesota, USA.) 15486985,The cytoskeleton differentially localizes the early growth response gene-1 protein in cancer and benign cells of the prostate.(Department of Urology Research, Mayo Clinic, Rochester, MN 55905, USA.) 14985468
ELF3 (1999) Gutierrez-Hartmann 2 ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells.(Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA. gro.cma|pnidehcs#gro.cma|pnidehcs) 14767472,The ETS transcription factor ESE-1 transforms MCF-12A human mammary epithelial cells via a novel cytoplasmic mechanism.(Medical Scienctist Training Program, University of Colorado Health Sciences Center, Denver, CO 80262, USA. ude.cshcu|ttocserp.nosaj#ude.cshcu|ttocserp.nosaj) 15169914
ELF3 (1999) Oettgen 2 ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation.(Beth Israel Deaconess Medical Center, Department of Medicine, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA.) 14715662,Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86.(Cardiology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA.) 15075319
ELF4 (2000) Kai 2 Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein.(Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan.) 14976184,MEF up-regulates human beta-defensin 2 expression in epithelial cells.(Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.) 15013761
ELF4 (2000) Nimer 2 The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2.(Division of Hematologic Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 575, New York, NY 10021, USA.) 16581786,Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells.(Laboratory of Molecular Aspects of Hematopoiesis, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. gro.ccksm|ctavdeh#gro.ccksm|ctavdeh) 14625302
ELF5 (2001) Sinha 2 Differentiation-specific transcriptional regulation of the ESE-2 gene by a novel keratinocyte-restricted factor.(Department of Biochemistry, State University of New York at Buffalo, Buffalo, New York 14214, USA.) 16229011,Determination of the consensus DNA-binding sequence and a transcriptional activation domain for ESE-2.(Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY 14214, USA.) 16704374
ELK1 (2002) Liu 2 PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells.(Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.) 16297876,TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1.(The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha 410081, Hunan, People's Republic of China.) 15351693
ELK1 (2002) Reddy 2 A Phosphatidylinositol 3-kinase-regulated Akt-independent signaling promotes cigarette smoke-induced FRA-1 expression.(Department of Environmental Health Sciences, Bloomberg School of Public Health and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA.) 16490785,Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements.(Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA.) 15806162
EPAS1 (2034) Harris 2 The relation between hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression with anemia and outcome in surgically treated head and neck cancer.(Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.) 16826581,The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer.(Harold Hopkins Department of Urology, Royal Berkshire Hospital, Reading, UK.) 16278385
EPAS1 (2034) Peet 2 Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment.(School of Molecular and Biomedical Science, University of Adelaide, South Australia.) 16760477,Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulator.(School of Molecular and Biomedical Science and the Centre for the Molecular Genetics of Development, University of Adelaide, Adelaide, South Australia, 5005, Australia.) 15653678
ESR1 (2099) Andò 4 Endogenous coactivator ARA70 interacts with estrogen receptor alpha (ERalpha) and modulates the functional ERalpha/androgen receptor interplay in MCF-7 cells.(Department of Pharmacobiology, University of Calabria, 87036 Arcavacata di Rende (CS), Italy.) 15772083,The red wine phenolics piceatannol and myricetin act as agonists for estrogen receptor alpha in human breast cancer cells.(Department of Pharmaco-Biology, University of Calabria, Rende (Cs), Italy.) 16216908,Estrogen receptor (ER)alpha and ER beta are both expressed in human ejaculated spermatozoa: evidence of their direct interaction with phosphatidylinositol-3-OH kinase/Akt pathway.(Centro Sanitario, University of Calabria 87030 Arcavacata di Rende, Cosenza, Italy. ti.orebil|vasiuqa#ti.orebil|vasiuqa) 15001646
ESR1 (2099) Brown 4 Global gene expression analysis of estrogen receptor transcription factor cross talk in breast cancer: identification of estrogen-induced/activator protein-1-dependent genes.(Department of Medicine, Baylor Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA.) 15514030,Cell cycle progression stimulated by tamoxifen-bound estrogen receptor-alpha and promoter-specific effects in breast cancer cells deficient in N-CoR and SMRT.(Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, D730, Boston, Massachusetts 02115, USA.) 15802375,Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1.(Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA.) 16009131
ESR1 (2099) Griffiths 3 Detection of mRNA levels for the estrogen alpha, estrogen beta and androgen nuclear receptor genes in archival breast cancer tissue.(Genomics Research Centre and Wesley Research Institute, School of Health Science, Griffith University Gold Coast, PMB 50 Gold Coast Mail Centre, Qld. 9726, Australia.) 16046054,No role for estrogen receptor 1 gene intron 1 Pvu II and exon 4 C325G polymorphisms in migraine susceptibility.(Genomics Research Centre, School of Health Science, Griffith University Gold Coast, PMB 50, Gold Coast Mail Centre, Queensland, 9726, Australia. ua.ude.htiffirg|nosloc.n#ua.ude.htiffirg|nosloc.n) 16504171,The estrogen receptor 1 G594A polymorphism is associated with migraine susceptibility in two independent case/control groups.(Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Queensland, Australia.) 15133719
ESR1 (2099) Gustafsson 4 Estrogen receptor (ER) beta modulates ERalpha-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen-responsive promoters.(Department of Biosciences at Novum, Karolinska Institutet, Huddinge 14157, Sweden. es.ik.icsoib|swehttam.nosaj#es.ik.icsoib|swehttam.nosaj) 16293641,Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters.(Department of Biosciences at Novum, Karolinska Institutet, Novum 14157, Sweden. es.ik.icsoib|swehttam.nosaj#es.ik.icsoib|swehttam.nosaj) 15964790,Estrogen receptor-alpha regulates SOCS-3 expression in human breast cancer cells.(Department of Biosciences at Novum, Karolinska Institutet, Novum, S-14157 Huddinge, Sweden. es.ik.icsoib|swehttam.nosaj#es.ik.icsoib|swehttam.nosaj) 16055089
ESR1 (2099) Kato 4 Splicing potentiation by growth factor signals via estrogen receptor phosphorylation.(Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan.) 15919818,Repressive domain of unliganded human estrogen receptor alpha associates with Hsc70.(The Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo-ku, Japan.) 16324147,Wnt/beta-catenin and estrogen signaling converge in vivo.(The Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.) 15304487
ESR1 (2099) Kumar 4 Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells.(Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.) 16684779,Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway.(Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.) 15169784,Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor alpha in breast cancer cells.(Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.) 15173068
ESR1 (2099) Lee 3 New role for nuclear hormone receptors and coactivators in regulation of BRCA1-mediated DNA repair in breast cancer cell lines.(Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA. ude.csu|eworcd#ude.csu|eworcd) 16417649,Loss of estrogen receptor-alpha expression is associated with hypermethylation near its ATG start codon in gastric cancer cell lines.(Department of Internal Medicine, College of Medicine, Catholic University, Seoul 137-040, Korea. rk.ca.cilohtac|oowkoosni#rk.ca.cilohtac|oowkoosni) 14767512,Association of estrogen receptor 1 intron 1 C/T polymorphism in Korean vitiligo patients.(Department of Pharmacology, College of Medicine, Kohwang Medical Research Institute, Kyung Hee University, Seoul 130-701, South Korea.) 15381239
ESR1 (2099) Marino 4 Survival versus apoptotic 17beta-estradiol effect: role of ER alpha and ER beta activated non-genomic signaling.(Department of Biology, University Roma Tre, Rome, Italy.) 15389627,Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol.(Department of Biology, University Roma Tre, I-00146 Rome, Italy.) 15496458,S-palmitoylation modulates human estrogen receptor-alpha functions.(Department of Biology, University Roma Tre, Viale G. Marconi, 446, I-00146, Rome, Italy.) 15033483
ESR1 (2099) Safe 5 Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.(Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, College Station, Texas 77843-4466, USA.) 16675542,Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins.(Department of Biochemistry, Texas A&M University, College Station, 77843-4466, USA.) 16574784,DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs.(Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas 77843-4466, USA.) 15625066
ESR1 (2099) Uitterlinden 4 Estrogen receptor alpha gene polymorphisms and anxiety disorder in an elderly population.() 15940291,Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women.(Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.) 16061840,Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction.(Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.) 15213208
ESR2 (2100) Andò 2 Estrogen receptor (ER)alpha and ER beta are both expressed in human ejaculated spermatozoa: evidence of their direct interaction with phosphatidylinositol-3-OH kinase/Akt pathway.(Centro Sanitario, University of Calabria 87030 Arcavacata di Rende, Cosenza, Italy. ti.orebil|vasiuqa#ti.orebil|vasiuqa) 15001646,Oestrogen receptor beta is required for androgen-stimulated proliferation of LNCaP prostate cancer cells.(Department of Pharmaco-Biology, University of Calabria, 87036 Rende (CS), Italy.) 15171712
ESR2 (2100) Gustafsson 3 Estrogen receptor (ER) beta modulates ERalpha-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen-responsive promoters.(Department of Biosciences at Novum, Karolinska Institutet, Huddinge 14157, Sweden. es.ik.icsoib|swehttam.nosaj#es.ik.icsoib|swehttam.nosaj) 16293641,Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D.(Department of Biosciences, Karolinska Institutet, Novum, S-14157 Huddinge, Sweden.) 14745018,Identification of tamoxifen-induced coregulator interaction surfaces within the ligand-binding domain of estrogen receptors.(Department of Biosciences at Novum, Karolinska Institutet, S-14157 Huddinge, Sweden.) 15060164
ESR2 (2100) Ho 2 Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling.(Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, College of Medicine, University of Cincinnati, OH 45267, USA.) 16938840,Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis.(Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01605-2324, USA.) 15161636
ESR2 (2100) Kang 2 Tamoxifen-resistant breast cancers show less frequent methylation of the estrogen receptor beta but not the estrogen receptor alpha gene.(Department of Biology, Dongguk University, 100-715 Seoul, Korea.) 15536519,CpG methylation of the ERalpha and ERbeta genes in breast cancer.(Department of Biology, Dongguk University, Seoul 100-715, Korea.) 15254780
ESR2 (2100) Levin 2 Nature of functional estrogen receptors at the plasma membrane.(Division of Endocrinology, Veterans Affairs Medical Center, Long Beach, CA 90822, USA.) 16645038,Plasma membrane estrogen receptors exist and functions as dimers.(Long Beach Veterans Affairs Medical Center/University of California-Irvine, 5901 East 7th Street, Long Beach, California 90822, USA.) 15231873
ESR2 (2100) Marino 2 Survival versus apoptotic 17beta-estradiol effect: role of ER alpha and ER beta activated non-genomic signaling.(Department of Biology, University Roma Tre, Rome, Italy.) 15389627,Mechanisms of naringenin-induced apoptotic cascade in cancer cells: involvement of estrogen receptor alpha and beta signalling.(Department of Biology, University Roma Tre, Viale G. Marconi, 446, I-00146 Rome, Italy.) 15545229
ESR2 (2100) Muyan 2 Binding of estrogen receptor beta to estrogen response element in situ is independent of estradiol and impaired by its amino terminus.(University of Rochester School of Medicine and Dentistry, Department of Biochemistry and Biophysics, Rochester, New York 14642, USA.) 15976006,Single-chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways.(Department of Biochemistry and Biophysics, University of Rochester School of Medicine, 601 Elmwood Ave., Rochester, NY 14642, USA.) 15314175
ESR2 (2100) Yager 2 Mitochondrial localization of ERalpha and ERbeta in human MCF7 cells.(Division of Toxicological Sciences, Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.) 14736707,Binding of MCF-7 cell mitochondrial proteins and recombinant human estrogen receptors alpha and beta to human mitochondrial DNA estrogen response elements.(Department of Environmental Health Sciences, Division of Toxicological Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe St. Baltimore, Maryland 21205-2179, USA. ude.cccf|nehc.gnaiqnij#ude.cccf|nehc.gnaiqnij) 15368362
ESR2 (2100) Zhu 2 Potentiation of estrogen receptor transcriptional activity by breast cancer amplified sequence 2.(Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.) 15694360,ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor.(Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.) 15047147
ESRRA (2101) Giguère 2 A single nucleotide in an estrogen-related receptor alpha site can dictate mode of binding and peroxisome proliferator-activated receptor gamma coactivator 1alpha activation of target promoters.(Molecular Oncology Group, McGill University Health Centre, Montréal, Québec, Canada H3A 1A1.) 16150865,A polymorphic autoregulatory hormone response element in the human estrogen-related receptor alpha (ERRalpha) promoter dictates peroxisome proliferator-activated receptor gamma coactivator-1alpha control of ERRalpha expression.(Molecular Oncology Group, McGill University Health Center, Montréal, Québec H3A 1A1, Canada.) 14978033
ETS1 (2113) Bosserhoff 2 Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1.(Institute of Pathology, University of Regensburg, 93053 Regensburg, Germany.) 16684505,The Ets-1 transcription factor is involved in the development and invasion of malignant melanoma.(Institute of Pathology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93042, Regensburg, Germany.) 14704859
ETS1 (2113) Sekine 3 Expression of Ets-1 proto-oncoprotein in gastrointestinal stromal tumors, leiomyomas and schwannomas.(Department of Molecular Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. pj.ca.u-ikasagan.ten|n-ihsot#pj.ca.u-ikasagan.ten|n-ihsot) 16586544,Expression of the ets-1 proto-oncogene in human breast carcinoma: differential expression with histological grading and growth pattern.(Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan.) 15578430,Overexpression of Ets-1 proto-oncogene in latent and clinical prostatic carcinomas.(Tissue and Histopathology Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.) 15693893
ETS1 (2113) Trojanowska 2 Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.(Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.) 16278291,Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program.(Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.) 16829517
ETS1 (2113) von Deimling 2
ETS1 (2113) Watson 2 SP100 inhibits ETS1 activity in primary endothelial cells.(Department of Pathology and Laboratory Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.) 15592518,SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion.(Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.) 15247905
ETS1 (2113) Wernert 2 Expression pattern of matrix metalloproteinase and TIMP genes in fibroblasts derived from Ets-1 knock-out mice compared to wild-type mouse fibroblasts.(Institute of Pathology, University of Bonn, 53011 Bonn, Germany.) 16786167,Ets-1 expression promotes epithelial cell transformation by inducing migration, invasion and anchorage-independent growth.(Institute of Pathology, University of Bonn, PO Box 2120, 53011 Bonn, Germany.) 15940256
ETV4 (2118) Shindoh 2 E1AF degradation by a ubiquitin-proteasome pathway.(Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, North 13 West 7, Kita-ku 060-8586, Sapporo, Japan.) 15629152,E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters.(Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, N13 W7, Kita-Ku, Sapporo 060-8586, Japan.) 15756447
FOS (2353) Wang 3 Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling.(Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.) 16023595,Effect of c-fos antisense probe on prostaglandin E2-induced upregulation of vascular endothelial growth factor mRNA in human liver cancer cells.(Comprehensive Diagnostic and Therapeutic Center, Xijing Hospital, the Fourth Military Medical University, Xi'an 710033, Shaanxi Province, China. nc.moc.oohay|33liqgnoy#nc.moc.oohay|33liqgnoy) 16038047,Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.(Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, GA 30912, USA.) 16236267
FOSL1 (8061) Reddy 2 A Phosphatidylinositol 3-kinase-regulated Akt-independent signaling promotes cigarette smoke-induced FRA-1 expression.(Department of Environmental Health Sciences, Bloomberg School of Public Health and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA.) 16490785,Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements.(Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA.) 15806162
FOXC1 (2296) Walter 4 Regulation of FOXC1 stability and transcriptional activity by an epidermal growth factor-activated mitogen-activated protein kinase signaling cascade.(Department of Ophthalmology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada. ac.atreblau|yrrebf#ac.atreblau|yrrebf) 16492674,FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner.(Department of Ophthalmology, University of Alberta, Edmonton, AB, Canada. ac.atreblau|yrrebf#ac.atreblau|yrrebf) 15684392,The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions.(Department of Ophthalmology, University of Alberta, Edmonton, Canada.) 15277473
FOXL2 (668) De Baere 2
FOXL2 (668) Veitia 2 Deletions in the polyAlanine-containing transcription factor FOXL2 lead to intranuclear aggregation.(INSERM U709 Génomique et Epigénétique des Pathologies Placentaires and Universités Paris V & VII, Paris 75014, France.) 16219626,A recurrent polyalanine expansion in the transcription factor FOXL2 induces extensive nuclear and cytoplasmic protein aggregation.(INSERM E0021 Génomique fonctionnelle du Développement, Hôpital Cochin, 123 bd du Port Royal, Bâtiment Baudelocque, 75014 Paris, France.) 15591279
FOXM1 (2305) Costa 2 Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase.(Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine, 60607-7170, USA.) 16314512,Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators.(Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA.) 15024056
FOXO1A (2308) Barr 2 Co-expression of alternatively spliced forms of PAX3, PAX7, PAX3-FKHR and PAX7-FKHR with distinct DNA binding and transactivation properties in rhabdomyosarcoma.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 15688409,Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.) 15184910
FOXO1A (2308) Tindall 2 CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage.(Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.) 17038621,Androgens negatively regulate forkhead transcription factor FKHR (FOXO1) through a proteolytic mechanism in prostate cancer cells.(Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.) 14726521
FOXO1A (2308) Unterman 2 FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression.(Departments of Medicine and Physiology and Biophysics, University of Illinois College of Medicine, Chicago, IL 60612, USA.) 16492665,Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms.(Department of Medicine, University of Illinois at Chicago College of Medicine, and Medical Research Unit, Chicago, IL 60612, USA.) 14664696
FOXO3A (2309) Chrousos 2 HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected patients.(Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, NIH, 10 Center Dr. MSC 1109, Building 10, Clinical Research Center, Room 1-3140, Bethesda, MD 20892-1109, USA. vog.hin.liam|tonik#vog.hin.liam|tonik) 15616007,Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?(Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1583, USA. vog.hin.liam|tonik#vog.hin.liam|tonik) 15265780
FOXO3A (2309) Lam 3 The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells.(Cancer Research-United Kingdom Laboratories, Department of Oncology, MRC Cyclotron Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom.) 16809346,Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.(Cancer Research-UK labs, Department of Cancer Medicine, MRC Cyclotron Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.) 15688014,FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism.(Cancer Research-UK Laboratories, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom.) 15509806
FOXP1 (27086) Banham 2 Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1alpha expression.(Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece. rg.tenhtrof.reh|grat#rg.tenhtrof.reh|grat) 16258506,Expression of the forkhead transcription factor FOXP1 is associated with estrogen receptor alpha and improved survival in primary human breast carcinomas.(Nuffield Department Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK. ku.ca.xo.slcdn|xof.nehpets#ku.ca.xo.slcdn|xof.nehpets) 15161711
FOXP3 (50943) Jacobson 2 Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways.(Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.) 16652169,Reduced Foxp3 protein expression is associated with inflammatory disease during human t lymphotropic virus type 1 Infection.(Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.) 16652285
FOXP3 (50943) Levings 2 The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.(Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.) 16211090,Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells.(Department of Surgery, University of British Columbia and Immunity and Infection Centre, Vancouver, BC.) 16339542
FOXP3 (50943) Ritz 2 IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo.(Division of Hematologic Malignancies, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA.) 16645171,Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease.(Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA.) 15972448
FOXP3 (50943) Ziegler 2 Insights into transcriptional regulation by FOXP3.(Department of Immunology, University of Washington, Seattle, WA 98195, USA.) 16368541,Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor.(Benaroya Research Institute, Virginia Mason, Seattle, WA 98101, USA.) 16920951
FOXR1 (283150) Katoh 2 Identification and characterization of human FOXN5 and rat Foxn5 genes in silico.(M&M Medical BioInformatics, Narashino 275-0022, Japan.) 15067358,Human FOX gene family (Review).(M&M Medical BioInformatics, Hongo 113-0033, Japan. pj.og.ccn|hotakm#pj.og.ccn|hotakm) 15492844
FOXR2 (139628) Katoh 2 Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico.(M and M Medical BioInformatics, Narashino 275-0022, Japan.) 15202009,Identification and characterization of human FOXK1 gene in silico.(M&M Medical BioInformatics, Narashino 275-0022, Japan. pj.og.ccn|hotakm#pj.og.ccn|hotakm) 15202027
GABPA (2551) Kong 2 Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif.(Department of Pharmaceutics, Ernest-Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, USA.) 15917227,Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein.(Department of Pharmaceutics, Ernest-Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.) 15020583
GATA1 (2623) Kanakura 2 Notch signals inhibit the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through the induction of HES1.(Department of Hematology and Oncology, Osaka University Graduate School of Medicine, 2-2, Yamada-oka, Suita, Osaka 565-0871, Japan.) 15563463,GATA transcription factors inhibit cytokine-dependent growth and survival of a hematopoietic cell line through the inhibition of STAT3 activity.(Department of Hematology/Oncology, Osaka University Graduate School of Medicine, 2-2, Yamada-oka, Suita, Osaka 565-0871, Japan.) 15673499
GATA1 (2623) Mackay 2 Molecular analysis of the interaction between the hematopoietic master transcription factors GATA-1 and PU.1.(School of Molecular and Microbial Biosciences, G08, University of Sydney, New South Wales 2006, Australia.) 16861236,Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction.(School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia.) 15644435
GATA1 (2623) Taub 2 Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia.(Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute of Environmental Sciences, Wayne State University, Detroit, MI 48201, USA.) 16249385,The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines.(Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, Michigan, USA.) 14744791
GATA1 (2623) Vyas 3 GATA1 mutation analysis demonstrates two distinct primary leukemias in a child with down syndrome; implications for leukemogenesis.() 16012335,Natural history of GATA1 mutations in Down syndrome.(Department of Hematology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK.) 14656875,Differences in the chromatin structure and cis-element organization of the human and mouse GATA1 loci: implications for cis-element identification.(Department of Haematology, Medical Research Council Molecular Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DU, United Kingdom.) 15265794
GATA3 (2625) Miyatake 2 Role of GATA-3 in IL-5 gene transcription by CD4+ T cells of asthmatic patients.(Department of Immunology, Tokyo Metropolitan Institute of Medical Science, Japan.) 15947486,GATA-3 suppresses IFN-gamma promoter activity independently of binding to cis-regulatory elements.(Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan.) 15251440
GATA4 (2626) Heikinheimo 2 High GATA-4 expression associates with aggressive behavior, whereas low anti-Müllerian hormone expression associates with growth potential of ovarian granulosa cell tumors.(Program for Developmental and Reproductive Biology, Biomedicum Helsinki, University of Helsinki, P.O. Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland. if.iknisleh|nenottna.okkim#if.iknisleh|nenottna.okkim) 16159935,Transcription factors GATA-4 and GATA-6 in human adrenocortical tumors.(Children's Hospital, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.) 15666845
GCM1 (8521) Chen 4 Histone deacetylase 3 binds to and regulates the GCMa transcription factor.(Graduate Institute of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan.) 16528103,FBW2 targets GCMa to the ubiquitin-proteasome degradation system.(Graduate Institute of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan.) 15640526,Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa.(Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan.) 16166624
GCM1 (8521) Hashemolhosseini 2 Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions.(University Hospital for Children and Adolescents, University of Erlangen-Nuremberg, Germany.) 16004993,Interaction, cooperative promoter modulation, and renal colocalization of GCMa and Pitx2.(Institut für Biochemie, Universität Erlangen-Nürnberg, Fahrstrasse 17, D-91054 Erlangen, Germany.) 15385555
GLI1 (2735) Panagopoulos 2 Activation of the GLI oncogene through fusion with the beta-actin gene (ACTB) in a group of distinctive pericytic neoplasms: pericytoma with t(7;12).(Department of Clinical Genetics, University Hospital, Lund, Sweden. es.ul.negnilk|nelhad.anna#es.ul.negnilk|nelhad.anna) 15111311,Molecular genetic characterization of the genomic ACTB-GLI fusion in pericytoma with t(7;12).(Department of Clinical Genetics, University Hospital, SE-221 85 Lund, Sweden. es.ul.negnilk|nelhad.anna#es.ul.negnilk|nelhad.anna) 15555571
GLI1 (2735) Xie 3 Hedgehog signaling is activated in subsets of esophageal cancers.(Institute of Developmental Biology, School of Life Sciences, Shandong University, Jinan, China.) 16003737,Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal.(Sealy Center for Cancer Cell Biology and Department of Pharmacology, University of Texas Medical Branch, Galveston, Texas 7555-1048, USA.) 16293631,Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas.(Institute of Developmental Biology, School of Life Sciences, Shandong University, Jinan, PR China.) 15905200
GMEB1 (10691) Nomura 2 Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury.(Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N12W6, Sapporo 060-0812, Japan.) 16497673,Regulation of procaspase-2 by glucocorticoid modulatory element-binding protein 1 through the interaction with caspase recruitment domain.(Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N12W6, Sapporo 060-0812, Japan.) 15555560
HIC1 (3090) Leprince 4 [Chromosome arm 17p13.3: could HIC1 be the one ?](ERI-8 Inserm, Signalisation des facteurs de croissance dans le cancer du sein, Protéomique fonctionnelle, UPRES EA 1033, IFR 118, Bâtiment SN3, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France. rf.1ellil-vinu|nipohc.eirelav#rf.1ellil-vinu|nipohc.eirelav) 16386221,A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP.(CNRS UMR 8526, Institut de Biologie de Lille, Institut Pasteur de Lille, France.) 16762039,Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1.(CNRS UMR 8526, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 Rue Calmette, 59017 Lille, France.) 15007385
HIF1A (3091) Brüne 5 Reactive oxygen species attenuate nitric-oxide-mediated hypoxia-inducible factor-1alpha stabilization.(Institute of Biochemistry I, Faculty of Medicine, Johann Wolfgang Goethe-University, Frankfurt, Germany.) 16631533,Calpain mediates a von Hippel-Lindau protein-independent destruction of hypoxia-inducible factor-1alpha.(Institute of Biochemistry I, Faculty of Medicine, Johann Wolfgang Goethe-University Frankfurt, 60590 Frankfurt, Germany.) 16421254,Retinoblastoma susceptibility gene product pRB activates hypoxia-inducible factor-1 (HIF-1).(Department of Medicine IV-Experimental Division, Faculty of Medicine, University of Erlangen-Nürnberg, 91054 Erlangen, Germany.) 15674338
HIF1A (3091) Caniggia 2 Dynamic HIF1A regulation during human placental development.(Department of Obstetrics and Gynecology, Mount Sinai Hospital, and Department of Physiology, University of Toronto, Ontario, Canada.) 16611863,Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1.(Mount Sinai Hospital, Department of Obstetrics, University of Toronto, Canada.) 16627691
HIF1A (3091) Fandrey 2 Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB.(Institut für Physiologie, Universität Duisburg-Essen Hufelandstrasse 55, D-45122 Essen, Federal Republic of Germany.) 16533170,Chelation of cellular calcium modulates hypoxia-inducible gene expression through activation of hypoxia-inducible factor-1alpha.(Institut für Physiologie, Universität Duisburg-Essen, Hufelandstrasse 55, D-45122 Essen, Germany.) 15322093
HIF1A (3091) Harris 3 The relation between hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression with anemia and outcome in surgically treated head and neck cancer.(Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.) 16826581,The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer.(Harold Hopkins Department of Urology, Royal Berkshire Hospital, Reading, UK.) 16278385,CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha.(Nuffield Department Clinical Laboratory Sciences, John Radcliffe Hospital and Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, Henry Wellcome Building of Genomic Medicine, University of Oxford, UK. ku.ca.xo.slcdn|xof.nehpets#ku.ca.xo.slcdn|xof.nehpets) 15342390
HIF1A (3091) Huang 4 HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.(Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.) 15780936,Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1.(Laboratory of Human Carcinogenesis, NCI, National Institutes of Health, Bethesda, MD 20892, USA.) 16157596,HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.(Laboratory of Human Carcinogenesis, NCI, National Institutes of Health, Bethesda, MD 20892, USA.) 15071503
HIF1A (3091) Kim 4 Tid-1 interacts with the von Hippel-Lindau protein and modulates angiogenesis by destabilization of HIF-1alpha.(Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea.) 15805242,Negative regulation of hypoxia inducible factor-1alpha by necdin.(Neurovascular Coordination Research Center and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.) 15978586,Epigallocatechin gallate inhibits HIF-1alpha degradation in prostate cancer cells.(Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA.) 16005427
HIF1A (3091) Maity 2 Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway.(Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.) 16849522,Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism.(Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19004, USA.) 15342781
HIF1A (3091) Park 5 The zinc chelator, N,N,N',N'-tetrakis (2-pyridylmethyl) ethylenediamine, increases the level of nonfunctional HIF-1alpha protein in normoxic cells.(Department of Life Science, University of Seoul, 90 Cheonnong-dong, Tongdaemun-gu, Seoul 130-743, Republic of Korea.) 16579968,Differential responses of two degradation domains of HIF-1alpha to hypoxia and iron deficiency.(Department of Pharmacology, Seoul National University College of Medicine, 28, Yongon-dong, Chongno-gu, Seoul 110-799, South Korea.) 16139409,Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinoma.(Division of Hematology/Oncology, Department of Medicine, Samsung Medical Center, Ilwon-Dong 50, Gangnam-Gu, Seoul 135-710, Korea.) 15809750
HIF1A (3091) Semenza 3 Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.(Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.) 15374877,OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.(Institute for Cell Engineering, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.) 15721254,Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling.(Department of Anesthesia, The Tazuke Kofukai Medical Research Institute Kitano Hospital, 2-4-20, Ohgimachi, Kita-ku, Osaka 530-8480, Japan. moc.cam|1fih#moc.cam|1fih) 15280370
HIF1A (3091) van Diest 3
HIF3A (64344) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
HNF4A (3172) Goldstein 2 The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter.(Human Metabolism Section, Laboratory of Pharmacology and Chemistry, National Institutes of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.) 15919766,Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha.(Laboratory of Pharmacology & Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.) 15933212
HNF4A (3172) Hadzopoulou-Cladaras 2 Distinct amino acid residues may be involved in coactivator and ligand interactions in hepatocyte nuclear factor-4alpha.(Department of Genetics, Development and Molecular Biology, Laboratory of Developmental Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece 54124.) 15826954,Critical role of residues defining the ligand binding pocket in hepatocyte nuclear factor-4alpha.(Aristotle University of Thessaloniki, Faculty of Sciences, School of Biology, Department of Genetics, Development and Molecular Biology, GR-54124, Thessaloniki, Greece.) 15123688
HNF4A (3172) Hansen 2 Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population.(Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, Gentofte, 2820, Copenhagen, Denmark. kd.onets|ahot#kd.onets|ahot) 15735891,Half of clinically defined maturity-onset diabetes of the young patients in Denmark do not have mutations in HNF4A, GCK, and TCF1.(Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, DK-2820 Gentofte, Denmark. kd.onets|ojda#kd.onets|ojda) 15928245
HNF4A (3172) Ryffel 2 HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma.(Institut für Zellbiologie (Tumorforschung), Universitätsklinikum Essen, D-45122 Essen, Germany.) 16007190,Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4alpha and HNF1beta in a pancreatic beta-cell line.(Institut für Zellbiologie (Tumorforschung), Universitätsklinikum Essen, D-45122 Essen, Germany.) 15520459
HNF4A (3172) Talianidis 2 Mitogen-activated protein kinase-mediated disruption of enhancer-promoter communication inhibits hepatocyte nuclear factor 4alpha expression.(Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Herakleion, Crete, Greece.) 16980607,Histone modifications defining active genes persist after transcriptional and mitotic inactivation.(Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Herakleion, Crete, Greece.) 15616580
HNRPK (3190) Cusack 2 X-ray crystallographic and NMR studies of the third KH domain of hnRNP K in complex with single-stranded nucleic acids.(Grenoble Outstation, European Molecular Biology Laboratory, 6 rue Jules Horowitz, BP 181, F-38042 Grenoble Cedex 9, France.) 16004877,Crystallization, microPIXE and preliminary crystallographic analysis of the complex between the third KH domain of hnRNP K and single-stranded DNA.(European Molecular Biology Laboratory, Grenoble Outstation, 6 Rue Jules Horowitz, BP 181, F-38042 Grenoble CEDEX 9, France.) 15039586
HNRPK (3190) Ostrowski 2 Editing of hnRNP K protein mRNA in colorectal adenocarcinoma and surrounding mucosa.(Department of Gastroenterology, Medical Center for Postgraduate Education and Maria SkÅodowska-Curie Memorial Cancer Center and Institute of Oncology, ul. Roentgena 5, Warsaw 02-781, Poland.) 16404425,hnRNP K: one protein multiple processes.(Department of Medicine, University of Washington, Seattle, WA 98195, USA. ude.notgnihsaw.u|blorak#ude.notgnihsaw.u|blorak) 15170860
HOXA10 (3206) Humphries 2 The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia.(Terry Fox Laboratory, British Columbia Cancer Agency, 11th Floor, 675 West 10th Ave, Vancouver, BC, Canada V5Z 1L3.) 16861351,Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1.(Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver V5Z 1L3, Canada.) 14966272
HOXA10 (3206) Taylor 4 HOXA10 expression in ectopic endometrial tissue.(Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA.) 16647375,Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells.(Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA.) 15905361,A HOXA10 estrogen response element (ERE) is differentially regulated by 17 beta-estradiol and diethylstilbestrol (DES).(Yale University School of Medicine, Division of Reproductive Endocrinology, P.O. Box 208063, 333 Cedar Street, New Haven, CT 06520-8063, USA.) 15236964
HOXA11 (3207) Taylor 2 HOXA10 gene expression in human fallopian tube and ectopic pregnancy.(Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA.) 15167850,The role of HOX genes in human implantation.(Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Yale University School of Medicine, 333 Cedar Street, P.O. Box 2008063, New Haven, CT 06520, USA.) 15731295
HOXA5 (3202) Raman 2 HOXA5 regulates hMLH1 expression in breast cancer cells.(Department of Radiology, Johns Hopkins University School of Medicine, 340 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA.) 16756717,HOXA5-twist interaction alters p53 homeostasis in breast cancer cells.(Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.) 15545268
HOXA5 (3202) Sukumar 2 Identification of transcriptional targets of HOXA5.(Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Hospital, Baltimore, Maryland 21231-1000, USA.) 15757903,HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8.(Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, CRB 410, Baltimore, MD 21231-1000, USA.) 14701762
HOXB13 (10481) Jeng 2 HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4.(Department of Urology, Walther Oncology Center, Indiana University, Indianapolis, Indiana 46202, USA. ude.iupui|gnujhc#ude.iupui|gnujhc) 15126340,HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling.(Department of Urology, Walther Oncology Center, Indiana University, Indianapolis, Indiana, USA.) 15604291
HOXB3 (3213) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
HOXB9 (3219) Sugano 2 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.(Life Science Research Laboratory, Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, 185-8601, Japan.) 16344560,Complete sequencing and characterization of 21,243 full-length human cDNAs.(Helix Research Institute, 1532-3 Yana, Kisarazu, Chiba 292-0812, Japan.) 14702039
HOXD10 (3236) Hootnick 2 A HOX gene mutation in a family with isolated congenital vertical talus and Charcot-Marie-Tooth disease.(Department of Clinical Pathology, State University of New York, Upstate Medical University, Syracuse, 13210, USA. ude.etatspu|atpmirhs#ude.etatspu|atpmirhs) 15146389,Congenital vertical talus in four generations of the same family.(Department of Medical Imaging, Crouse Hospital, 736 Irving Ave., Syracuse, NY 13210, USA. moc.rr.yncwt|lme#moc.rr.yncwt|lme) 15368082
ID1 (3397) Cheung 2 Id-1 promotes proliferation of p53-deficient esophageal cancer cells.(Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.) 16506209,Id helix-loop-helix proteins are differentially expressed in gestational trophoblastic disease.(Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.) 16115231
ID1 (3397) Schwartz 2 E12 and E47 modulate cellular localization and proteasome-mediated degradation of MyoD and Id1.(Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA.) 16007194,Ubiquitin-Proteasome-mediated degradation of Id1 is modulated by MyoD.(Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St. Louis Children's Hospital, Missouri 63110, USA.) 15163661
ID1 (3397) Wong 4 Proteasome mediated degradation of Id-1 is associated with TNFalpha-induced apoptosis in prostate cancer cells.(Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China.) 16123120,Inactivation of Id-1 in prostate cancer cells: A potential therapeutic target in inducing chemosensitization to taxol through activation of JNK pathway.(Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong.) 16287090,Overexpression of Id-1 in prostate cancer cells promotes angiogenesis through the activation of vascular endothelial growth factor (VEGF).(Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China.) 15905202
ID2 (3398) Iavarone 2 The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system.(Institute for Cancer Genetics, Department of Pathology, Pediatrics, and Neurology, Columbia University Medical Center, New York, NY 10032, USA.) 16549780,Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.(Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA.) 16810178
IRF1 (3659) Ball 2 A novel repressor domain is required for maximal growth inhibition by the IRF-1 tumor suppressor.(Cancer Research UK (CRUK) Interferon and Cell Signalling Group, Cell Signalling Unit, The University of Edinburgh Cancer Research Centre, Edinburgh EH4 2XR, United Kingdom.) 16679314,Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53.(CRUK Interferon and Cell Signalling Group, Cell Signalling Unit, Cancer Research Centre, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, United Kingdom.) 15509808
IRF1 (3659) Clarke 2 Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis.(Lombardi Comprehensive Cancer Center and Department of Oncology, Georgetown University School of Medicine, 3970 Reservoir Road NW, Washington, DC 20057, USA.) 15878912,interferon regulatory factor-1 mediates the proapoptotic but not cell cycle arrest effects of the steroidal antiestrogen ICI 182,780 (faslodex, fulvestrant).(Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, District of Columbia 20007, USA.) 15173018
IRF1 (3659) Lee 2 Alternative splicing variants of IRF-1 lacking exons 7, 8, and 9 in cervical cancer.(Molecular Therapy Research Center, Sungkyunkwan University, Seoul 135-710, Republic of Korea.) 16857162,IFN-gamma/IRF-1-induced p27kip1 down-regulates telomerase activity and human telomerase reverse transcriptase expression in human cervical cancer.(Molecular Therapy Research Center, School of Medicine, Sungkyunkwan University, Samsung Medical Center Annex 8F, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Korea.) 15710386
IRF1 (3659) Ross 2 Retinoic acid exerts dual regulatory actions on the expression and nuclear localization of interferon regulatory factor-1.(Department of Nutritional Sciences, 126-S Henderson Building, University Park, PA 16802, USA.) 16636311,Physiological and receptor-selective retinoids modulate interferon gamma signaling by increasing the expression, nuclear localization, and functional activity of interferon regulatory factor-1.(Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.) 16085646
IRF1 (3659) Watanabe 3 IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome.(Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Japan.) 15907481,Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells.(Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.) 15226432,Regulation of hepatitis C virus replication by interferon regulatory factor 1.(Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.) 15331704
IRF3 (3661) Gale 3 West Nile virus evades activation of interferon regulatory factor 3 through RIG-I-dependent and -independent pathways without antagonizing host defense signaling.(Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, USA.) 16501100,Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection.(Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.) 16585524,The host response to West Nile Virus infection limits viral spread through the activation of the interferon regulatory factor 3 pathway.(Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9048, USA.) 15220448
IRF3 (3661) Mossman 2 The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes.(Lady Davis Research Institute, Montreal H3T 1E2, Canada.) 14747533,Innate cellular response to virus particle entry requires IRF3 but not virus replication.(Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5.) 14747536
IRF3 (3661) Sen 2 Analysis of genes induced by Sendai virus infection of mutant cell lines reveals essential roles of interferon regulatory factor 3, NF-kappaB, and interferon but not toll-like receptor 3.(Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195, USA.) 15767394,Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling.(Department of Molecular Biology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.) 15502848
IRF3 (3661) Shu 3 VISA is an adapter protein required for virus-triggered IFN-beta signaling.(Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA.) 16153868,Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.(Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA. gro.cjn|huhs#gro.cjn|huhs) 14739303,PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis.(National Jewish Medical and Research Center, 1400 Jackson Street, k516c, Denver, CO 80206, USA.) 15251447
IRF6 (3664) Vikkula 2 Interferon regulatory factor-6: a gene predisposing to isolated cleft lip with or without cleft palate in the Belgian population.(Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology and University of Louvain Medical School, Brussels, Belgium.) 16132054,Six families with van der Woude and/or popliteal pterygium syndrome: all with a mutation in the IRF6 gene.(Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology and Universite catholique de Louvain, Avenue Hippocrate 74+4, Brussels, Belgium.) 14757865
JUN (3725) Chen 3 Japanese encephalitis virus NS2B-NS3 protease binding to phage-displayed human brain proteins with the domain of trypsin inhibitor and basic region leucine zipper.(Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan, Taiwan, ROC. wt.ude.umc.liam|nilwc#wt.ude.umc.liam|nilwc) 16289409,Estrogen receptor inhibits c-Jun-dependent stress-induced cell death by binding and modifying c-Jun activity in human breast cancer cells.(Department of Radiation Oncology and Division of Biochemistry of the Department of Cell Biology, Neurobiology, and Anatomy, Loyola University of Chicago, Maywood, Illinois 05163.) 14638681,A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.(Gene Transfer Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Largo R. Benzi 10, 16132 Genoa, Italy. moc.oohay|izrehgr#moc.oohay|izrehgr) 15175153
JUN (3725) He 2 Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis.(Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese Human Genome Center of Beijing, Beijing, PR China.) 15706351,Direct association of hepatopoietin with thioredoxin constitutes a redox signal transduction in activation of AP-1/NF-kappaB.(Laboratory of Systems Biology, Beijing Institute of Radiation Medicine, Chinese Human Genome Center at Beijing.) 15894171
JUN (3725) Liu 2 A novel human KRAB-containing zinc-finger gene ZNF446 inhibits transcriptional activities of SRE and AP-1.(The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China. ude.cshmat.tbi|uilm#ude.cshmat.tbi|uilm) 15936718,TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1.(The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha 410081, Hunan, People's Republic of China.) 15351693
JUN (3725) Wang 2 Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling.(Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.) 16023595,Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.(Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, GA 30912, USA.) 16236267
KLF4 (9314) Ruppert 2 Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia.(Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.) 15674344,Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer.(Department of Cell Biology, University of Alabama at Birmingham, 35294, USA.) 15102675
KLF4 (9314) Yang 4 Transcriptional profiling of the cell cycle checkpoint gene krüppel-like factor 4 reveals a global inhibitory function in macromolecular biosynthesis.(Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.) 17017123,Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage.(Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.) 15806166,Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage.(Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.) 14627709
KLF5 (688) Dong 2 Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells.(Department of Oncology and Hematology, Winship Cancer Institute, Emory University School of Medicine, 1365-C Clifton Road, Atlanta, GA, USA.) 15735697,Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells.(Winship Cancer Institute and Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.) 16223724
KLF5 (688) Nagai 3 The deacetylase HDAC1 negatively regulates the cardiovascular transcription factor Krüppel-like factor 5 through direct interaction.(Department of Cardiovascular Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.) 15668237,Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.(Department of Cardiovascular Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan.) 16054042,Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB.(Department of Cardiovascular Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.) 14573617
KLF5 (688) Yang 2 Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras.(Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA.) 15077182,All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Kruppel-like factor 5.(Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 201 Whitehead Research Building, 615 Michael Street, Atlanta, GA, USA.) 15581624
KLF7 (8609) Maeda 2 Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line.(Laboratory for Diabetic Nephropathy, SNP Research Center, The Institute of Physical and Chemical Research, Kanagawa 230-0045, Japan.) 16339272,Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes.(Laboratory for Diabetic Nephropathy, SNP Research Centre, Institute of Physical and Chemical Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.) 15937668
LEF1 (51176) Engelhardt 2 Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis.(Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.) 15194563,Characterization of Lef-1 promoter segments that facilitate inductive developmental expression in skin.(Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa 52242-1109, USA.) 15245424
LEF1 (51176) Waterman 2 Wnt activation and alternative promoter repression of LEF1 in colon cancer.(Department of Microbiology and Molecular Genetics, Rm. B240, Medical Sciences I, University of California, Irvine, Irvine, CA 92697-4025, USA. ude.icu|mretawlm#ude.icu|mretawlm) 16809766,An internal ribosome entry site mediates translation of lymphoid enhancer factor-1.(Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, CA 92697-4025, USA.) 16120831
LHX3 (8022) Rhodes 4 Two promoters mediate transcription from the human LHX3 gene: involvement of nuclear factor I and specificity protein 1.(Department of Biology (B.C.Y., M.G.), Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202, USA.) 16179410,Clinical case seminar: a novel LHX3 mutation presenting as combined pituitary hormonal deficiency.(Pediatric Endocrinology Division, Infant's and Children's Hospital of Brooklyn at Maimonides, Brooklyn, New York 11219, USA.) 16394081,Serine/threonine/tyrosine phosphorylation of the LHX3 LIM-homeodomain transcription factor.(Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202-5132, USA.) 15517599
LHX4 (89884) Amselem 2 Functional relationship between LHX4 and POU1F1 in light of the LHX4 mutation identified in patients with pituitary defects.(Institut National de la Santé et de la Recherche Médicale, Unité 654, Hôpital Henri Mondor, 94010 Créteil, France.) 15998782,Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development.(Génétique Moléculaire et Physiopathologie, INSERM U468, Hôpital Henri Mondor, Créteil 94010, France.) 15567726
MAFA (389692) Stein 3 FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site.(Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medical Center,723 Light Hall, Nashville, TN 37232, USA.) 16847327,The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription.(Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.) 15665000,The MafA transcription factor appears to be responsible for tissue-specific expression of insulin.(Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 723 Light Hall, Nashville, TN 37232, USA.) 14973194
MAPK8IP1 (9479) Lee 2 Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators.(Department of Surgery and Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.) 15911620,Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop.(Department of Surgery and Pharmacology, University of Pittsburgh, Pittsburgh, PA 15213, USA.) 15998799
MAZ (4150) Ray 3 Inflammation-responsive transcription factor SAF-1 activity is linked to the development of amyloid A amyloidosis.(Department of Veterinary Pathobiology, University of Missouri, 126A Connaway Hall, Columbia, MO 65211, USA. ude.iruossim|layar#ude.iruossim|layar) 16888022,Overexpression of serum amyloid A-activating factor 1 inhibits cell proliferation by the induction of cyclin-dependent protein kinase inhibitor p21WAF-1/Cip-1/Sdi-1 expression.(Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA. ude.iruossim|layar#ude.iruossim|layar) 15067082,Induction of the MMP-14 gene in macrophages of the atherosclerotic plaque: role of SAF-1 in the induction process.(Department of Veterinary Pathobiology, University of Missouri, 126A Connaway Hall, 1600 E Rollins Rd, Columbia, MO 65211, USA. ude.iruossim|layar#ude.iruossim|layar) 15528467
MEF2A (4205) Wang 2 Advances in the genetic basis of coronary artery disease.(Department of Molecular Cardiology, Lerner Research Institute/ ND4-38, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. gro.fcc|2qgnaw#gro.fcc|2qgnaw) 15811259,Molecular genetics of coronary artery disease.(Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA. gro.fcc|2qgnaw#gro.fcc|2qgnaw) 15861005
MEIS1 (4211) Pellerin 2 PBX1 intracellular localization is independent of MEIS1 in epithelial cells of the developing female genital tract.(UMR 6061, Genetique et Developpement, IFR 140, Universite de Rennes 1, Campus Villejean, Rennes, France.) 16172981,A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical' Hoxa9 protein during embryogenesis.(UMR 6061, Génétique et Développement, IFR 97, Université de Rennes 1, Campus Villejean, 2 avenue du Professeur Léon Bernard, CS34317, F-35043 Rennes, France.) 15161102
MITF (4286) Fisher 6 c-Met expression is regulated by Mitf in the melanocyte lineage.(Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.) 16455654,Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.(Melanoma Program in Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.) 16766266,Sumoylation of MITF and its related family members TFE3 and TFEB.(Dana-Farber Cancer Institute and Children's Hospital, Department of Pediatric Hematology/Oncology, Melanoma Program in Medical Oncology, Harvard Medical School, Boston, Massachusetts 02115, USA.) 15507434
MITF (4286) Sellers 2 From integrated genomics to tumor lineage dependency.(Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. ude.dravrah.icfd|yawarraG_iveL#ude.dravrah.icfd|yawarraG_iveL) 16510564,Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.(Department of Medical Oncology, and Melanoma Program in Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA.) 16001072
MLL (4297) Cleary 2 Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.(Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.) 15199122,Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein.(Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.) 15542854
MLL (4297) Roeder 2 Regulation of MLL1 H3K4 methyltransferase activity by its core components.(Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA.) 16878130,Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.(Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA.) 15960975
MLLT7 (4303) Burgering 2 FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).(Department of Physiological Chemistry, Center for Biomedical Genetics, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands.) 15126506,FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.(Department of Physiological Chemistry, Centre for Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.) 15538382
MYB (4602) Ishii 3 Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK.(Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, Tsukuba, Ibaraki 305-0074, Japan.) 15082531,Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation.(Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan.) 15308626,p53 suppresses c-Myb-induced trans-activation and transformation by recruiting the corepressor mSin3A.(Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan.) 15509555
MYB (4602) Thein 2 cMYB is involved in the regulation of fetal hemoglobin production in adults.(Department of Haematological Medicine, King's College London School of Medicine at King's College Hospital, Denmark Hill Campus, London SE5 9PJ, United Kingdom.) 16861354,Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin expression in adults.(Department of Haematological Medicine, GKT School of Medicine, London, SE5 9PJ, UK. ku.ca.xo.hcysp|esolc.semaj#ku.ca.xo.hcysp|esolc.semaj) 15169551
MYC (4609) Chowdhury 2 Quadruplex-duplex competition in the nuclease hypersensitive element of human c-myc promoter: C to T mutation in C-rich strand enhances duplex association.(Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110007, India.) 15629428,Kinetic resolution of bimolecular hybridization versus intramolecular folding in nucleic acids by surface plasmon resonance: application to G-quadruplex/duplex competition in human c-myc promoter.(Institute of Genomics and Integrative Biology, CSIR Mall Road, Delhi 110007, India.) 16085756
MYC (4609) Dang 3 Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis.(Program in Human Genetics and Molecular Biology, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.) 16508012,Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis.(Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.) 15988031,Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays.(Graduate Program of Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.) 15199147
MYC (4609) Huang 3 HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.(Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.) 15780936,IL-5 inhibits apoptosis by upregulation of c-myc expression in human hematopoietic cells.(Graduate Institute of Medical Sciences, Taipei Medical University, Hsinyi District, Taipei 110, Taiwan.) 15965094,HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.(Laboratory of Human Carcinogenesis, NCI, National Institutes of Health, Bethesda, MD 20892, USA.) 15071503
MYC (4609) Johnson 2 ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.(Department of Carcinogenesis, University of Texas M. D. Anderson Cancer Center, Science Park Research Division, 1808 Park Road 1C, Smithville, TX 78957, USA.) 16432227,Oncogenes and the DNA damage response: Myc and E2F1 engage the ATM signaling pathway to activate p53 and induce apoptosis.(The University of Texas MD Anderson Cancer Center, Science Park Research Division, Department of Carcinogenesis, Smithville, Texas, USA.) 16582589
MYC (4609) Jung 2 c-Myc over-expression in Ramos Burkitt's lymphoma cell line predisposes to iron homeostasis disruption in vitro.(Héma-Québec, Recherche et Développement, 1009 route du Vallon, Sainte-Foy, Quebec, Canada G1V 5C3.) 16466700,Iron specific growth inhibition of Burkitt's lymphoma cells in vitro, associated with a decrease in translocated c-myc expression.(Héma-Québec, Recherche et Développement, route du Vallon, Sainte-Foy, Québec, Canada.) 15468060
MYC (4609) León 2 Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway.(Grupo de Biología Molecular del Cáncer, Departamento de Biología Molecular, Unidad de Biomedicina del Consejo Superior de Investigaciones Cientiíficas, Facultad de Medicina, Universidad de Cantabria, 39011 Santander, Spain.) 15528212,Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes.(Departamento de Biología Molecular y Unidad de Biomedicina-CSIC, Grupo de Biología Molecular del Cáncer, Facultad de Medicina, University of Cantabria, Santander 39011, Spain.) 15856024
MYC (4609) Leffak 2 Differential binding of replication proteins across the human c-myc replicator.(Department of Biochemistry and Molecular Biology, Wright State University, 3640 Colonel Glenn Highway, Dayton, Ohio 45435, USA.) 16809765,Transcription factor binding and induced transcription alter chromosomal c-myc replicator activity.(Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA.) 15542830
MYC (4609) Levens 4 The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression.(Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892-1500, USA.) 16628215,The CT-element of the c-myc gene does not predispose to chromosomal breakpoints in Burkitt's lymphoma.(Institute of Pathology, Johannes Gutenberg-University of Mainz, Langenbeckstr. 1, 55101 Mainz, Germany. ed.zniam-inu.kinilk.eigolohtap|rebew#ed.zniam-inu.kinilk.eigolohtap|rebew) 16675879,TFIIH operates through an expanded proximal promoter to fine-tune c-myc expression.(Gene Regulation Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute/NIH, Bldg. 10, Rm. 2N106, Bethesda, MD 20892-1500, USA.) 15601838
MYC (4609) Martinez 2 Six lysine residues on c-Myc are direct substrates for acetylation by p300.(Department of Chemistry, University of California at Riverside, Riverside, CA 92521, USA.) 16126174,Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription.(Department of Biochemistry, University of California Riverside, Riverside, CA 92521, USA.) 16287840
MYC (4609) Wang 3 Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter region.(Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.) 16706751,Polyamine-modulated expression of c-myc plays a critical role in stimulation of normal intestinal epithelial cell proliferation.(Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.) 15355849,c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts.(The Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, The Sir Mortimer B. Davis-Jewish General Hospital, and Department of Medicine, McGill University, Montréal, Québec, Canada.) 16167342
MYCN (4613) Ross 2 Loss of one HuD allele on chromosome #1p selects for amplification of the N-myc proto-oncogene in human neuroblastoma cells.(Laboratory of Neurobiology, Department of Biological Sciences, Fordham University, Bronx, NY 10458, USA.) 16278682,Nestin is a potential mediator of malignancy in human neuroblastoma cells.(Laboratory of Neurobiology, Department of Biological Sciences, Fordham University, 441 East Fordham Road, Bronx, NY 10458, USA.) 15117961
MYOD1 (4654) Schwartz 2 E12 and E47 modulate cellular localization and proteasome-mediated degradation of MyoD and Id1.(Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA.) 16007194,Ubiquitin-Proteasome-mediated degradation of Id1 is modulated by MyoD.(Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St. Louis Children's Hospital, Missouri 63110, USA.) 15163661
NFATC2 (4773) Rao 2 FOXP3 controls regulatory T cell function through cooperation with NFAT.(Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA.) 16873067,A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1.(CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.) 15121840
NFE2L2 (4780) Jaiswal 3 Nuclear factor Nrf2 and antioxidant response element regulate NRH:quinone oxidoreductase 2 (NQO2) gene expression and antioxidant induction.(Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.) 16545679,Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants.(Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA.) 15734732,Nuclear import and export signals in control of Nrf2.(Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA.) 15901726
NFE2L2 (4780) O'Connell 2 Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells.(MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, CB1 9NL, UK.) 16123320,Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C.(Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, United Kingdom.) 16177082
NFE2L2 (4780) Yamamoto 4 Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer.(RIKEN Genomic Sciences Center, Tsurumi, Yokohama 230-0045, Japan.) 16507366,Predictive base substitution rules that determine the binding and transcriptional specificity of Maf recognition elements.(Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8577, Japan.) 16716189,Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells.(Environmental Response Project ERATO-Japan Science and Technology Agency, Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan.) 15917255
NFKB1 (4790) Aggarwal 2 Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.(Cytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, the University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.) 16624823,Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis.(Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.) 15090542
NFKB1 (4790) Brown 2 Intracellular inhibitory effects of Velcade correlate with morphoproteomic expression of phosphorylated-nuclear factor-kappaB and p53 in breast cancer cell lines.(Weis Center for Research, Geisinger Medical Center, Danville, Pennsylvania 17822, USA.) 15830705,Overexpression of phosphorylated nuclear factor-kappa B in tonsillar squamous cell carcinoma and high-grade dysplasia is associated with poor prognosis.(Division of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822-0131, USA.) 15920558
NFKB1 (4790) Chiao 3 Identification of an autoregulatory feedback pathway involving interleukin-1alpha in induction of constitutive NF-kappaB activation in pancreatic cancer cells.(Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.) 14679213,Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB.(Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.) 15102862,NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity.(Department of Surgical Oncology, Box 107, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.) 15314185
NFKB1 (4790) Greene 3 NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation.(Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA.) 16319923,Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement.(Gladstone Institute of Virology and Immunology, University of California, 94158, USA.) 16237100,p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1.(Gladstone Institute of Virology and Immunology and the Department of Medicine, University of California, San Francisco, California 94143-1234, USA.) 15073170
NFKB1 (4790) Kim 6 Nuclear factor-kappaB activated by capacitative Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells.(Research Institute of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.) 16490783,Transcriptional regulation of human CC chemokine CCL15 gene by NF-kappaB and AP-1 elements in PMA-stimulated U937 monocytoid cells.(Graduate School of Biotechnology and Institute of Life Sciences and Resources, Kyung Hee University, Yongin 449-701, Korea.) 16364464,Dimethylsulfoxide induces upregulation of tumor suppressor protein PTEN through nuclear factor-kappaB activation in HL-60 cells.(Department of Biochemistry, Chonbuk National University Medical School, Chonju 560-182, Republic of Korea.) 15725474
NFKB1 (4790) Lin 4 17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway.(Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA.) 16424045,Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation.(Deptartment of Molecular and Cellular Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, Texas 77030, USA.) 16543241,TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation.(Department of Molecular and Cellular Oncology, Department of Immunology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030, USA.) 16260783
NFKB1 (4790) Miyamoto 3 NFKB1 is a direct target of the TAL1 oncoprotein in human T leukemia cells.(Program in Molecular and Cellular Pharmacology, Department of Pharmacology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.) 16778171,PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress.(Program in Molecular and Cellular Pharmacology, Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA.) 16906147,Enhanced G2-M arrest by nuclear factor-{kappa}B-dependent p21waf1/cip1 induction.(Department of Pharmacology, University of Wisconsin, 301 Service Memorial Institute, 1300 University Avenue, Madison, WI 53706, USA.) 15972853
NFKB1 (4790) Perkins 2 Differential regulation of NF-kappaB activation and function by topoisomerase II inhibitors.(School of Life Sciences, Division of Gene Regulation and Expression, MSI/WTB, Complex, Dow Street, University of Dundee, Dundee, DD1 5EH, Scotland, UK. ku.ca.eednud|llebpmac.j.k#ku.ca.eednud|llebpmac.j.k) 16630341,Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.(School of Life Sciences, Division of Gene Regulation and Expression, MSI/WTB Complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.) 15053878
NFKB1 (4790) Shu 3 Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.(Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA. gro.cjn|huhs#gro.cjn|huhs) 14739303,Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB.(Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA.) 14769797,PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis.(National Jewish Medical and Research Center, 1400 Jackson Street, k516c, Denver, CO 80206, USA.) 15251447
NFKB1 (4790) Weiner 3 The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 16429131,HIV-1 Vpr and anti-inflammatory activity.(Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.) 15142381,HIV-1 Vpr: enhancing sensitivity of tumors to apoptosis.(Dept. of Pathology and Lab. Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.) 16305395
NFKB2 (4791) Sun 2 beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870.(Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, P.O. Box 850, Hershey, Pennsylvania 17033, USA.) 16303288,Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation.(Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA. ude.sregtur.ygoloib|oaix#ude.sregtur.ygoloib|oaix) 15140882
NFKB2 (4791) Xiao 4 Regulation of NF-kappa B2 p100 processing by its cis-acting domain.(Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.) 15485830,Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100.(Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, 604 Allison Rd., Piscataway, New Jersey 08854, USA.) 15677466,Stabilization of basally translated NF-kappaB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100.(Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.) 16223731
NKX2-5 (1482) Borlak 2 Novel NKX2-5 mutations in diseased heart tissues of patients with cardiac malformations.(Department of Drug Research and Medical Biotechnology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany.) 15161646,Somatic NKX2-5 mutations as a novel mechanism of disease in complex congenital heart disease.(Drug Research and Medical Biotechnology, Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai-Fuchs-Strasse 1, D-30625 Hanover, Germany.) 15342699
NKX3-1 (4824) Bieberich 2 NKX3.1 is regulated by protein kinase CK2 in prostate tumor cells.(Department of Biological Sciences, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA.) 16581776,Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF.(Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250, USA.) 15523673
NR0B1 (190) Achermann 2 Analysis of DAX1 (NR0B1) and steroidogenic factor-1 (NR5A1) in children and adults with primary adrenal failure: ten years' experience.(UCL Institute of Child Health and Department of Medicine, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom.) 16684822,The role of SF1/DAX1 in adrenal and reproductive function.(Biochemistry, Endocrinology & Metabolism, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK. ku.ca.lcu.hci|nnamrehca.j#ku.ca.lcu.hci|nnamrehca.j) 15988384
NR0B2 (8431) Choi 3 Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD.(Hormone Research Center, School of Biological Resources and Technology, Chonnam National University, Kwangju 500-757, Republic of Korea.) 14752053,Differential regulation of human and mouse orphan nuclear receptor small heterodimer partner promoter by sterol regulatory element binding protein-1.(Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Kwangju 500-757, Republic of Korea.) 15123650,Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding.(Hormone Research Center, Chonnam National University, Gwangju 500-757, Korea.) 15358835
NR1D1 (9572) Lazar 2 Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock.(Division of Endocrinology, Diabetes, and Metabolism, and University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA.) 16484495,The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene.(Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia 19104-6149, USA.) 15761026
NR1H2 (7376) Tontonoz 2 Phosphorylation of the liver X receptors.(Department of Pathology and Laboratory Medicine, University of California-Los Angeles, CA 90095, USA.) 16904112,Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors.(Howard Hughes Medical Institute, University of California, Los Angeles, California 90095-1662, USA.) 14699103
NR1H2 (7376) Vidal 2 Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells.(INSERM U449, INRA U1235, Laennec Faculty of Medicine, Claude Bernard University of Lyon, Lyon, France.) 16482468,Towards a proteome-scale map of the human protein-protein interaction network.(Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA.) 16189514
NR1H3 (10062) Tontonoz 3 Phosphorylation of the liver X receptors.(Department of Pathology and Laboratory Medicine, University of California-Los Angeles, CA 90095, USA.) 16904112,Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha.(Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA.) 16170053,Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors.(Howard Hughes Medical Institute, University of California, Los Angeles, California 90095-1662, USA.) 14699103
NR1H3 (10062) Vidal 2 Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells.(INSERM U449, INRA U1235, Laennec Faculty of Medicine, Claude Bernard University of Lyon, Lyon, France.) 16482468,Towards a proteome-scale map of the human protein-protein interaction network.(Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA.) 16189514
NR1H4 (9971) Burris 2 Regulation of carbohydrate metabolism by the farnesoid X receptor.(Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.) 15564327,Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor.(Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, IN 46285, USA.) 15721319
NR1H4 (9971) Edwards 4 FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.(Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.) 16251721,Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling.(Department of Biological Chemistry and Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.) 15604525,Alpha-crystallin is a target gene of the farnesoid X-activated receptor in human livers.(Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.) 16012168
NR1H4 (9971) Jingami 2 The region of CQQQKPQRRP of PGC-1alpha interacts with the DNA-binding complex of FXR/RXRalpha.(Department of Molecular Biology, Biomolecular Engineering Research Institute (BERI), Osaka, Japan.) 16494845,The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner.(Department of Molecular Biology, Biomolecular Engineering Research Institute (BERI), 6-2-3 Furuedai, Suita-City, Osaka 565-0874, Japan.) 15202934
NR1I2 (8856) Goldstein 2 The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter.(Human Metabolism Section, Laboratory of Pharmacology and Chemistry, National Institutes of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.) 15919766,Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha.(Laboratory of Pharmacology & Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.) 15933212
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