Sample Result
Profiles
Other numbers
- 38605 Human Genes
- 10180 MeSH Disease terms
Data Sources
- MeSH 2008
- PubMed Baseline-2008
- Predictions using Entrez Gene 2007-02-13
- Validation using Entrez Gene 2008-04-10
Statistics (GeneRIF)
- 219715 Predicted Disease-Gene Tuples
- 293636 Current Disease-Gene Tuples
- 74897 New Tuples
- 69292 New Tuples with predicted score (missing new terms?)
Highest Scoring Results (Top 100) - Oct 20, 2008
Comparison using GeneRIF as a reference source
| Gene | MeSH Disease Term | Score | generif |
|---|---|---|---|
| LY75 (4065) | Carcinoma | -78538.8017492 | 17592270 Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms. |
| RBM14 (10432) | Cell Transformation, Neoplastic | -69004.649738 | 16878147 Gene amplification and associated loss of 5' regulatory sequences of CoAA in human cancers. |
| CD37 (951) | Leukemia | -67686.5578958 | 17440052 Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical. |
| MGAT4B (11282) | Carcinoma | -67111.4131064 | 17488527 N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma. |
| HSPA7 (3311) | Carcinoma | -65797.8089973 | 17163517 Highly sensitive detection of cytotoxicity using a modified HSP70B' promoter. |
| TWIST2 (117581) | Carcinoma | -65079.0988456 | 17487558 Possible involvement of TWIST in enhanced peritoneal metastasis of epithelial ovarian carcinoma. |
| MMP25 (64386) | Carcinoma | -64736.3312152 | 17513868 MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties. |
| DMTF1 (9988) | Neoplasms | -63537.6869295 | 15010895 Single nucleotide polymorphisms in breast cancer. |
| VSIG4 (11326) | Inflammation | -62800.6914467 | 16882875 Z39Ig is expressed on macrophages and may mediate inflammatory reactions in arthritis and atherosclerosis. |
| CD37 (951) | Neoplasms by Histologic Type | -62259.7646289 | 17440052 Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical. |
| DHRS9 (10170) | Neoplasms by Histologic Type | -61858.0232456 | 17244623 Epstein-Barr virus lytic infection induces retinoic acid-responsive genes through induction of a retinol-metabolizing enzyme, DHRS9. |
| CD37 (951) | Neoplasms | -60341.0504264 | 17440052 Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical. |
| ADAM8 (101) | Disease Progression | -60239.7154935 | 17339047 Increased expression of ADAM33 and ADAM8 with disease progression in asthma. |
| NNAT (4826) | Carcinoma | -60065.9994808 | 17805055 Neuronatin expression and its clinicopathological significance in pulmonary non-small cell carcinoma. |
| SEMA6A (57556) | Neoplasms | -58834.5659117 | 17671748 Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells. |
| BCAR3 (8412) | Disease Models, Animal | -58247.1583937 | 17270363 Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling. |
| PRSS21 (10942) | Neoplasms by Histologic Type | -58122.1437706 | 16810501 Epigenetic silencing of the putative tumor suppressor gene testisin in testicular germ cell tumors. |
| BCAR3 (8412) | Neoplasms, Experimental | -57717.6845602 | 17270363 Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling. |
| OR51E1 (143503) | Carcinoma | -56853.0817287 | 16206286 PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer. |
| CD37 (951) | Immunoproliferative Disorders | -55787.3847577 | 17440052 Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical. |
| LZTS1 (11178) | Carcinoma | -55585.9735172 | 12851677 Down-regulation of FEZ1/LZTS1 gene with frequent loss of heterozygosity in oral squamous cell carcinomas. |
| ADAM8 (101) | Skin and Connective Tissue Diseases | -55356.533218 | 17548643 Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding. |
| CD37 (951) | Immune System Diseases | -54977.3238707 | 17440052 Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical. |
| CD37 (951) | Lymphoproliferative Disorders | -54901.4883833 | 17440052 Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical. |
| OR51E1 (143503) | Neoplasms, Glandular and Epithelial | -54854.3228339 | 16206286 PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer. |
| CADPS2 (93664) | Disease Models, Animal | -54565.2341999 | 17380209 Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients. |
| UGT1A3 (54659) | Carcinoma | -53987.7519569 | 15057901 Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. |
| ACADVL (37) | Genetic Diseases, Inborn | -53567.4011677 | 17457695 Effects of a fat load and exercise on asymptomatic VLCAD deficiency. 17514507 Very long chain acyl-CoA dehydrogenase deficiency in a pair of mildly affected monozygotic twin sister in their late fifties. |
| DHRS9 (10170) | Neoplasms, Experimental | -53397.9310142 | 17244623 Epstein-Barr virus lytic infection induces retinoic acid-responsive genes through induction of a retinol-metabolizing enzyme, DHRS9. |
| ACADVL (37) | Metabolism, Inborn Errors | -53040.7880698 | 17457695 Effects of a fat load and exercise on asymptomatic VLCAD deficiency. 17514507 Very long chain acyl-CoA dehydrogenase deficiency in a pair of mildly affected monozygotic twin sister in their late fifties. |
| IGHG2 (3501) | Immune System Diseases | -52966.6235241 | 16944158 Immunoglobulin GM and KM genotypes in Korean patients with systemic lupus erythematosus. |
| PARP14 (54625) | Carcinoma | -52705.2764474 | 17478423 Collaborator of Stat6 (CoaSt6)-associated poly(ADP-ribose) polymerase activity modulates Stat6-dependent gene transcription. |
| DLEC1 (9940) | Carcinoma | -52447.6355186 | 17099870 Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma. |
| SLC39A3 (29985) | Carcinoma | -52291.2844582 | 17550612 hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands. |
| SLC39A2 (29986) | Carcinoma | -52291.2844582 | 17550612 hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands. |
| LY75 (4065) | Neoplasms, Glandular and Epithelial | -51680.4116378 | 17592270 Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms. |
| HOXA4 (3201) | Immunoproliferative Disorders | -51562.373561 | 16688227 Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL. |
| OR51E1 (143503) | Neoplasms by Histologic Type | -51498.5077175 | 16206286 PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer. |
| CLK2 (1196) | DNA Damage | -51333.9905216 | 17384638 HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability. |
| BCAR3 (8412) | Neoplastic Processes | -51314.2406154 | 17616674 Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling. |
| AKR7A2 (8574) | Neoplasms by Histologic Type | -51036.6873018 | 17591773 Synthesis and catabolism of gamma-hydroxybutyrate in SH-SY5Y human neuroblastoma cells: role of the aldo-keto reductase AKR7A2. |
| CD37 (951) | Lymphatic Diseases | -50887.0180292 | 17440052 Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical. |
| MGAT4B (11282) | Neoplasms, Glandular and Epithelial | -50770.0954738 | 17488527 N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma. |
| USP18 (11274) | Neoplasms | -50653.3471942 | 17374743 Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling. |
| EPHA7 (2045) | Neoplasms by Histologic Type | -50640.3902649 | 17726105 ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias. |
| UBE2B (7320) | Carcinoma | -50634.3077001 | 17050667 Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells. |
| NRG4 (145957) | Prostatic Neoplasms | -50629.3981992 | 17545517 Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer. |
| RBM14 (10432) | Neoplastic Processes | -50439.4858108 | 16878147 Gene amplification and associated loss of 5' regulatory sequences of CoAA in human cancers. |
| C13orf15 (28984) | Neuroectodermal Tumors | -50417.6261616 | 17146433 RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. |
| CD37 (951) | Hemic and Lymphatic Diseases | -50258.1849111 | 17440052 Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical. |
| USP18 (11274) | Leukemia | -50202.7637736 | 17374743 Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling. |
| CD37 (951) | Leukemia, Lymphoid | -49937.5101598 | 17440052 Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical. |
| PRSS21 (10942) | Neoplasms, Germ Cell and Embryonal | -49749.6914051 | 16810501 Epigenetic silencing of the putative tumor suppressor gene testisin in testicular germ cell tumors. |
| C13orf15 (28984) | Neoplasms, Germ Cell and Embryonal | -49748.3726673 | 17146433 RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. |
| LY75 (4065) | Neuroectodermal Tumors | -49653.6258537 | 17592270 Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms. |
| MGAT4B (11282) | Neoplasms by Histologic Type | -49621.3703581 | 17488527 N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma. |
| C13orf15 (28984) | Neoplasms, Nerve Tissue | -49476.9057344 | 17146433 RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. |
| ADAM8 (101) | Immune System Diseases | -49367.3989186 | 17339047 Increased expression of ADAM33 and ADAM8 with disease progression in asthma. 17548643 Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding. |
| HOXA4 (3201) | Lymphoproliferative Disorders | -49287.1261669 | 16688227 Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL. |
| TNF (7124) | Neoplasms, Neuroepithelial | -48908.2005787 | 17114809 Tumor necrosis factor-alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent Akt activation and cyclin D expression. |
| CHD5 (26038) | Cell Transformation, Neoplastic | -48849.4786188 | 17289567 CHD5 is a tumor suppressor at human 1p36. |
| ADI1 (55256) | Neoplasms by Site | -48712.0981526 | 17786183 Expression and function of the human androgen-responsive gene ADI1 in prostate cancer. |
| PSMD9 (5715) | Digestive System Neoplasms | -48677.1341428 | 17360176 p53 and p27 as predictors of clinical outcome for rectal-cancer patients receiving neoadjuvant therapy. |
| HOXA4 (3201) | Leukemia, Lymphoid | -48454.0236697 | 16688227 Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL. |
| PALLD (23022) | Carcinoma | -48415.5737569 | 17194196 Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism. 17228136 Familial pancreatic cancer: hope can become truth. |
| TNN (63923) | Neoplastic Processes | -48394.0752086 | 17909022 Tenascin-W is a novel marker for activated tumor stroma in low-grade human breast cancer and influences cell behavior. |
| BCAR3 (8412) | Mammary Neoplasms, Animal | -48376.4935389 | 17270363 Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling. |
| IL1RAPL2 (26280) | Skin and Connective Tissue Diseases | -48329.967059 | 17265504 Immunolocalization of interleukin-1 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies. |
| LY75 (4065) | Neoplasms, Germ Cell and Embryonal | -47886.3092791 | 17592270 Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms. |
| TWIST2 (117581) | Neoplastic Processes | -47718.5641094 | 17487558 Possible involvement of TWIST in enhanced peritoneal metastasis of epithelial ovarian carcinoma. |
| UGT1A8 (54576) | Carcinoma | -47606.2436731 | 15057901 Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. |
| CAMTA1 (23261) | Chromosome Aberrations | -47590.972167 | 17222547 Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma. |
| LY75 (4065) | Neoplasms, Nerve Tissue | -47544.4567975 | 17592270 Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms. |
| USP18 (11274) | Neoplasms by Histologic Type | -47428.9594591 | 17374743 Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling. |
| USP18 (11274) | Leukemia, Myeloid | -47257.1024539 | 17374743 Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling. |
| SRPRB (58477) | Carcinoma | -47228.2669933 | 17080297 Introduction of G1 phase arrest in Human Hepatocellular carcinoma cells (HHCC) by APMCF1 gene transfection through the down-regulation of TIMP3 and up-regulation of the CDK inhibitors p21. |
| NRG4 (145957) | Genital Neoplasms, Male | -46942.5652376 | 17545517 Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer. |
| TXN2 (25828) | Carcinoma | -46874.1157898 | 16868544 Interactions between genes involved in the antioxidant defence system and breast cancer risk. |
| NRG4 (145957) | Prostatic Diseases | -46864.5253919 | 17545517 Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer. |
| CHD5 (26038) | Neoplastic Processes | -46857.2322136 | 17289567 CHD5 is a tumor suppressor at human 1p36. |
| C13orf15 (28984) | Neoplasms, Neuroepithelial | -46711.0034444 | 17146433 RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. |
| SH2D3C (10044) | Neoplasms | -46599.9782086 | 17270363 Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling. 17427198 AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. |
| AKR7A2 (8574) | Neoplasms, Glandular and Epithelial | -46597.8150688 | 17591773 Synthesis and catabolism of gamma-hydroxybutyrate in SH-SY5Y human neuroblastoma cells: role of the aldo-keto reductase AKR7A2. |
| NNAT (4826) | Neoplasms, Glandular and Epithelial | -46579.2056978 | 17805055 Neuronatin expression and its clinicopathological significance in pulmonary non-small cell carcinoma. |
| PSMD9 (5715) | Colorectal Neoplasms | -46508.271755 | 17360176 p53 and p27 as predictors of clinical outcome for rectal-cancer patients receiving neoadjuvant therapy. |
| IGHG1 (3500) | Immune System Diseases | -46498.9952644 | 15517630 Immunoglobulin KM and GM gene polymorphisms modify the clinical presentation of primary Sjögren's syndrome. 16944158 Immunoglobulin GM and KM genotypes in Korean patients with systemic lupus erythematosus. 17177686 Immunoglobulin constant heavy G chain genes as risk factors in childhood allergies. |
| POU3F2 (5454) | Neoplasms, Neuroepithelial | -46216.7948851 | 17163992 Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells. |
| MMP25 (64386) | Neoplasms | -46164.9280461 | 17513868 MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties. |
| MGAT4B (11282) | Liver Neoplasms | -46066.3863117 | 17488527 N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma. |
| CNOT7 (29883) | Breast Neoplasms | -45850.8813855 | 17264152 hCAF1, a new regulator of PRMT1-dependent arginine methylation. |
| ACADVL (37) | Congenital, Hereditary, and Neonatal Diseases and Abnormalities | -45793.883856 | 17457695 Effects of a fat load and exercise on asymptomatic VLCAD deficiency. 17514507 Very long chain acyl-CoA dehydrogenase deficiency in a pair of mildly affected monozygotic twin sister in their late fifties. |
| SH2D3C (10044) | Disease Models, Animal | -45705.0377728 | 17270363 Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling. |
| MGAT4B (11282) | Adenocarcinoma | -45701.9267411 | 17488527 N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma. |
| LIMD1 (8994) | Breast Neoplasms | -45547.0162956 | 17889706 Identification of rare variants in the hLIMD1 gene in breast cancer. |
| LY75 (4065) | Adenocarcinoma | -45508.3088387 | 17592270 Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms. |
| PSMD9 (5715) | Gastrointestinal Neoplasms | -45367.7767172 | 17360176 p53 and p27 as predictors of clinical outcome for rectal-cancer patients receiving neoadjuvant therapy. |
| TNF (7124) | Glioma | -45307.0736085 | 17114809 Tumor necrosis factor-alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent Akt activation and cyclin D expression. |
| PSMD9 (5715) | Intestinal Neoplasms | -45237.8288709 | 17360176 p53 and p27 as predictors of clinical outcome for rectal-cancer patients receiving neoadjuvant therapy. |
| KIR2DS3 (3808) | Leukemia | -44805.5646684 | 17462498 Donor-recipient combinations of group A and B KIR haplotypes and HLA class I ligand affect the outcome of HLA-matched, sibling donor hematopoietic cell transplantation. |
| KIR2DS5 (3810) | Leukemia | -44805.5646684 | 17490516 [Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia] |
Stats (Gene2Pubmed)
- 399885 Predicted Disease-Gene Tuples
- 494481 Current Disease-Gene Tuples
- 97381 New Tuples
- 93209 New Tuples with predicted score ( Should validate that the missing tuples involve new disease terms )
Highest Scoring Results (Top 100) - Oct 18, 2008
Comparison using Gene2pubmed as a reference source
| Gene | MeSH Disease Term | Score | gene2pubmed |
|---|---|---|---|
| FAM148A (145741) | Neoplasms | -55291.8270268 | 16341674 Transcriptome analysis of human gastric cancer. |
| CD24L4 (938) | Carcinoma | -50059.0059177 | 1327504 CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. |
| LCN9 (392399) | Neoplasms | -46348.2305259 | 15164053 DNA sequence and analysis of human chromosome 9. |
| COL28A1 (340267) | Neoplasms | -45503.947797 | 12690205 Human chromosome 7: DNA sequence and biology. |
| hCG_1651160 (136157) | Chromosome Aberrations | -44885.626631 | 12690205 Human chromosome 7: DNA sequence and biology. |
| UNCX (340260) | Chromosome Aberrations | -44885.626631 | 12690205 Human chromosome 7: DNA sequence and biology. |
| hCG_1983332 (441246) | Chromosome Aberrations | -44885.626631 | 12690205 Human chromosome 7: DNA sequence and biology. |
| OCM (654231) | Chromosome Aberrations | -44885.626631 | 1559707 The genes for the highly homologous Ca(2+)-binding proteins oncomodulin and parvalbumin are not linked in the human genome. |
| DISC2 (27184) | Genetic Predisposition to Disease | -44746.4867114 | 15478311 DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness. |
| FAM148A (145741) | Digestive System Neoplasms | -44049.0448428 | 16341674 Transcriptome analysis of human gastric cancer. |
| KIR2DP1 (554300) | Neoplasms | -43570.5234537 | 17490516 [Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia] |
| DISC2 (27184) | Disease Susceptibility | -43215.7228209 | 15478311 DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness. |
| KIR2DP1 (554300) | Leukemia | -43192.1123182 | 17490516 [Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia] |
| FAM148A (145741) | Neoplasms by Site | -43188.26843 | 16341674 Transcriptome analysis of human gastric cancer. |
| KIR2DP1 (554300) | Neoplasms by Histologic Type | -43041.0227247 | 17490516 [Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia] |
| KIR2DP1 (554300) | Leukemia, Myeloid | -42769.5450393 | 17490516 [Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia] |
| ILK-2 (55522) | Digestive System Neoplasms | -42498.8749693 | 16987993 Epigenetic regulation of integrin-linked kinase expression depending on adhesion of gastric carcinoma cells. |
| SCA18 (94008) | Heredodegenerative Disorders, Nervous System | -41876.9851528 | 15148151 Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families. |
| LGMD1F (404679) | Genetic Predisposition to Disease | -41624.2354197 | 15316618 [Limb girdle muscular dystrophies] |
| hCG_38984 (345051) | Carcinoma | -41595.9575065 | 11752456 Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |
| LGMD1F (404679) | Disease Susceptibility | -41384.9915881 | 15316618 [Limb girdle muscular dystrophies] |
| SRC (6714) | DNA Damage | -40779.1502551 | 11564893 The modified human DNA repair enzyme O(6)-methylguanine-DNA methyltransferase is a negative regulator of estrogen receptor-mediated transcription upon alkylation DNA damage. |
| TNF (7124) | Epstein-Barr Virus Infections | -40507.9162874 | 11756988 Tumor necrosis factor-alpha and interleukin-10 promoter polymorphisms in Epstein-Barr virus-associated gastric carcinoma. 16824159 Use of cytokine polymorphisms and Epstein-Barr virus viral load to predict development of post-transplant lymphoproliferative disorder in paediatric liver transplant recipients. 17700165 Evidence for genetic susceptibility towards development of posttransplant lymphoproliferative disorder in solid organ recipients. |
| SCA18 (94008) | Neurodegenerative Diseases | -40343.8104043 | 15148151 Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families. |
| SCA18 (94008) | Genetic Diseases, Inborn | -40281.1986495 | 15148151 Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families. |
| CD24L4 (938) | Neoplasms by Histologic Type | -40279.8987692 | 1327504 CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. |
| TNF (7124) | Leukemia-Lymphoma, Adult T-Cell | -40189.2042348 | 11163081 Tumor necrosis factor, tumor necrosis factor receptors type 1 and 2, lymphotoxin-alpha, and HLA-DRB1 gene polymorphisms in human T-cell lymphotropic virus type I associated myelopathy. 11325850 Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers. 17495957 Blockade of death receptor-mediated pathways early in the signaling cascade coincides with distinct apoptosis resistance in cutaneous T-cell lymphoma cells. |
| COL28A1 (340267) | Chromosome Aberrations | -39807.9073125 | 12690205 Human chromosome 7: DNA sequence and biology. |
| SPINT3 (10816) | Genetic Diseases, Inborn | -39736.7616545 | 11780052 The DNA sequence and comparative analysis of human chromosome 20. |
| tcag7.565 (285872) | Chromosome Aberrations | -39638.4341825 | 12690205 Human chromosome 7: DNA sequence and biology. |
| PRAGMIN (157285) | Neoplasms | -39607.8496786 | 12471243 The protein kinase complement of the human genome. |
| ILK-2 (55522) | Neoplasms by Site | -39447.0465201 | 16987993 Epigenetic regulation of integrin-linked kinase expression depending on adhesion of gastric carcinoma cells. |
| KIR2DP1 (554300) | Immunoproliferative Disorders | -39278.437415 | 17490516 [Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia] |
| hCG_1795283 (642345) | Disease Susceptibility | -39191.2709976 | 11991713 An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia. |
| ERBB2 (2064) | Leukemia | -39117.4626148 | 2995967 A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma. |
| OCM (654231) | Chromosome Deletion | -39108.3700211 | 1559707 The genes for the highly homologous Ca(2+)-binding proteins oncomodulin and parvalbumin are not linked in the human genome. |
| SCA18 (94008) | Congenital, Hereditary, and Neonatal Diseases and Abnormalities | -39089.981086 | 15148151 Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families. |
| KIR2DP1 (554300) | Leukemia, Lymphoid | -39082.6371392 | 17490516 [Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia] |
| hCG_1795283 (642345) | Genetic Predisposition to Disease | -38917.102826 | 11991713 An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia. |
| CD24L4 (938) | Neoplasms | -38909.2509102 | 1327504 CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. |
| CD24L4 (938) | Neoplasms, Glandular and Epithelial | -38634.6739834 | 1327504 CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. |
| HPV6AI1 (3259) | Tumor Virus Infections | -38389.3563353 | 12697057 Refined physical map of the human PAX2/HOX11/NFKB2 cancer gene region at 10q24 and relocalization of the HPV6AI1 viral integration site to 14q13.3-q21.1. |
| KIR2DP1 (554300) | Disease Susceptibility | -38380.7782413 | 17490516 [Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia] |
| TNF (7124) | Glioblastoma | -38364.0491903 | 17114809 Tumor necrosis factor-alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent Akt activation and cyclin D expression. |
| VEGFA (7422) | Leukemia, Myeloid, Acute | -37952.1405608 | 16507781 Genomic polymorphisms provide prognostic information in intermediate-risk acute myeloblastic leukemia. |
| IL10 (3586) | Sarcoma | -37755.4643854 | 16702372 Associations of classic Kaposi sarcoma with common variants in genes that modulate host immunity. 17483704 TNF-alpha, TNF-beta, IL-6, IL-10, PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma. |
| KIR2DP1 (554300) | Lymphoproliferative Disorders | -37705.6782179 | 17490516 [Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia] |
| hCG_1651160 (136157) | Genetic Diseases, Inborn | -37575.6802819 | 12690205 Human chromosome 7: DNA sequence and biology. |
| UNCX (340260) | Genetic Diseases, Inborn | -37575.6802819 | 12690205 Human chromosome 7: DNA sequence and biology. |
| hCG_2040224 (347544) | Genetic Diseases, Inborn | -37575.6802819 | 9286695 Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. |
| hCG_1983332 (441246) | Genetic Diseases, Inborn | -37575.6802819 | 12690205 Human chromosome 7: DNA sequence and biology. |
| OCM (654231) | Genetic Diseases, Inborn | -37575.6802819 | 12853948 The DNA sequence of human chromosome 7. |
| C20orf187 (728434) | Genetic Diseases, Inborn | -37575.6802819 | 11780052 The DNA sequence and comparative analysis of human chromosome 20. |
| IL6 (3569) | Neoplasms, Experimental | -37283.6856445 | 15686457 Effect of IL-6 promoter polymorphism on incidence and outcome in Hodgkin's lymphoma. 16824159 Use of cytokine polymorphisms and Epstein-Barr virus viral load to predict development of post-transplant lymphoproliferative disorder in paediatric liver transplant recipients. |
| ERVK5 (60358) | Neoplasms by Histologic Type | -37202.2085293 | 7983737 Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas. |
| IGHJ@ (3506) | Leukemia | -37167.1780999 | 17169423 Use of IGHJ and IGHD gene mutations in analysis of immunoglobulin sequences for the prognosis of chronic lymphocytic leukemia. |
| CDKN1A (1026) | Neoplasms, Experimental | -37085.9622526 | 10208428 Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. |
| ERVK5 (60358) | Neoplasms | -37048.3636725 | 7983737 Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas. |
| COL28A1 (340267) | Genetic Diseases, Inborn | -36911.2267358 | 12690205 Human chromosome 7: DNA sequence and biology. |
| AKT1 (207) | Leukemia, Myeloid | -36582.4641505 | 17128418 Inhibition of Flt3-activating mutations does not prevent constitutive activation of ERK/Akt/STAT pathways in some AML cells: a possible cause for the limited effectiveness of monotherapy with small-molecule inhibitors. 17215852 Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts. 17581609 Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway. 17638918 BCR-tyrosine 177 plays an essential role in Ras and Akt activation and in human hematopoietic progenitor transformation in chronic myelogenous leukemia. |
| KRTAP10-11 (386678) | Genetic Diseases, Inborn | -36486.787566 | 10830953 The DNA sequence of human chromosome 21. |
| KRTAP12-3 (386683) | Genetic Diseases, Inborn | -36486.787566 | 10830953 The DNA sequence of human chromosome 21. |
| KRTAP12-4 (386684) | Genetic Diseases, Inborn | -36486.787566 | 10830953 The DNA sequence of human chromosome 21. |
| KRTAP10-12 (386685) | Genetic Diseases, Inborn | -36486.787566 | 10830953 The DNA sequence of human chromosome 21. |
| IGHJ@ (3506) | Neoplasms by Histologic Type | -36301.5805654 | 17169423 Use of IGHJ and IGHD gene mutations in analysis of immunoglobulin sequences for the prognosis of chronic lymphocytic leukemia. |
| KIR2DP1 (554300) | Bone Marrow Diseases | -36267.9738247 | 17490516 [Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia] |
| CDKN1A (1026) | Disease Models, Animal | -36264.7329003 | 10208428 Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. |
| IL6 (3569) | Melanoma | -36203.785911 | 12394188 Interleukin-10, interleukin-6 and interferon-gamma gene polymorphisms in melanoma patients. 14675394 Cytokine gene single nucleotide polymorphisms and susceptibility to and prognosis in cutaneous malignant melanoma. |
| SPINT3 (10816) | Congenital, Hereditary, and Neonatal Diseases and Abnormalities | -36050.6779715 | 11780052 The DNA sequence and comparative analysis of human chromosome 20. |
| IGHJ@ (3506) | Leukemia, Lymphoid | -35913.9855282 | 17169423 Use of IGHJ and IGHD gene mutations in analysis of immunoglobulin sequences for the prognosis of chronic lymphocytic leukemia. |
| IGHJ@ (3506) | Immunoproliferative Disorders | -35808.3795736 | 17169423 Use of IGHJ and IGHD gene mutations in analysis of immunoglobulin sequences for the prognosis of chronic lymphocytic leukemia. |
| CD24L4 (938) | Neuroectodermal Tumors | -35757.2955918 | 1327504 CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. |
| KIR2DP1 (554300) | Myeloproliferative Disorders | -35503.4176672 | 17490516 [Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia] |
| IGHJ@ (3506) | Lymphoproliferative Disorders | -35325.6390233 | 17169423 Use of IGHJ and IGHD gene mutations in analysis of immunoglobulin sequences for the prognosis of chronic lymphocytic leukemia. |
| CD24L4 (938) | Neoplasms, Germ Cell and Embryonal | -35299.2571017 | 1327504 CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. |
| CD24L4 (938) | Adenocarcinoma | -35195.5636624 | 1327504 CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. |
| IGHJ@ (3506) | Neoplasms | -35049.618929 | 17169423 Use of IGHJ and IGHD gene mutations in analysis of immunoglobulin sequences for the prognosis of chronic lymphocytic leukemia. |
| IL6 (3569) | Nevi and Melanomas | -35017.6093034 | 12394188 Interleukin-10, interleukin-6 and interferon-gamma gene polymorphisms in melanoma patients. 14675394 Cytokine gene single nucleotide polymorphisms and susceptibility to and prognosis in cutaneous malignant melanoma. |
| CD24L4 (938) | Neoplasms, Nerve Tissue | -34984.1537117 | 1327504 CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. |
| FAM148A (145741) | Gastrointestinal Neoplasms | -34916.673283 | 16341674 Transcriptome analysis of human gastric cancer. |
| TNF (7124) | Genetic Diseases, X-Linked | -34690.0393709 | 17353161 An association study of inflammatory cytokine gene polymorphisms in Fabry disease. |
| MCCD1 (401250) | Genetic Diseases, Inborn | -34648.661786 | 14574404 The DNA sequence and analysis of human chromosome 6. |
| AKT1 (207) | Leukemia, Myeloid, Acute | -34621.0132305 | 17215852 Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts. |
| IL10 (3586) | Leukemia, Myeloid | -34588.7070802 | 12028020 Allele and haplotype frequency at human leucocyte antigen class I/II and immunomodulatory cytokine loci in patients with myelodysplasia and acute myeloid leukaemia: in search of an autoimmune aetiology. 15932621 Cytokine gene polymorphism in Iranian patients with chronic myelogenous leukaemia. |
| FSHMD1B (2490) | Disease Susceptibility | -34548.1227339 | 10732819 Further exclusion of FSHD1B from the telomeric region of 10q. |
| KIR2DP1 (554300) | Lymphatic Diseases | -34321.5772351 | 17490516 [Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia] |
| FSHMD1B (2490) | Genetic Predisposition to Disease | -34249.7027424 | 10732819 Further exclusion of FSHD1B from the telomeric region of 10q. |
| KIR2DP1 (554300) | Immune System Diseases | -33828.93424 | 17490516 [Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia] |
| NOS2B (201288) | Disease Susceptibility | -33715.2150414 | 11525805 No linkage or association of the nitric oxide synthase genes to multiple sclerosis. |
| IFNG (3458) | Melanoma | -33591.4438926 | 12394188 Interleukin-10, interleukin-6 and interferon-gamma gene polymorphisms in melanoma patients. 14675394 Cytokine gene single nucleotide polymorphisms and susceptibility to and prognosis in cutaneous malignant melanoma. 15709194 Impact of gene polymorphisms on clinical outcome for stage IV melanoma patients treated with biochemotherapy: an exploratory study. |
| IFNG (3458) | Leukemia, Myeloid | -33591.3917653 | 15932621 Cytokine gene polymorphism in Iranian patients with chronic myelogenous leukaemia. |
| TP53 (7157) | Tauopathies | -33416.2959189 | 12648751 An association study of the codon 72 polymorphism in the pro-apoptotic gene p53 and Alzheimer's disease. |
| TP53 (7157) | Alzheimer Disease | -33409.2103058 | 12648751 An association study of the codon 72 polymorphism in the pro-apoptotic gene p53 and Alzheimer's disease. |
| KIR2DP1 (554300) | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | -33364.812441 | 17490516 [Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia] |
| ERBB2 (2064) | Immunoproliferative Disorders | -33360.8648163 | 8095488 Characterization of a new allele of the human ERBB2 gene by allele-specific competition hybridization. 17200337 Radiation effects on development of HER2-positive breast carcinomas. |
| SCA18 (94008) | Spinocerebellar Degenerations | -33310.4345479 | 15148151 Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families. |
| IGHJ@ (3506) | Lymphatic Diseases | -32964.3055613 | 17169423 Use of IGHJ and IGHD gene mutations in analysis of immunoglobulin sequences for the prognosis of chronic lymphocytic leukemia. |
| KIR2DP1 (554300) | Hemic and Lymphatic Diseases | -32836.0457376 | 17490516 [Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia] |
| IFNG (3458) | Nevi and Melanomas | -32814.6491436 | 12394188 Interleukin-10, interleukin-6 and interferon-gamma gene polymorphisms in melanoma patients. 14675394 Cytokine gene single nucleotide polymorphisms and susceptibility to and prognosis in cutaneous malignant melanoma. 15709194 Impact of gene polymorphisms on clinical outcome for stage IV melanoma patients treated with biochemotherapy: an exploratory study. |
| FSHMD1B (2490) | Pathologic Processes | -32772.921398 | 10732819 Further exclusion of FSHD1B from the telomeric region of 10q. |